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Sept. 9, 2020

SLAS NEWS

Listen to Scientists Join Mike and SLAS Board President Emilio Diez-Monedero for the latest New Matter: Inside the Minds of SLAS Scientists podcast as they discuss the impact of COVID-19 on scientific enterprise, how all jobs are global jobs and which moments of professional inspiration led Emilio to his current calling as a consultant and investor in small-stage rare disease companies. LISTEN NOW

Just Published: SLAS2021 Digital Schedule-at-a-Glance SLAS The wait is over. Satisfy your SLAS2021 Digital programming curiosity with a look at the just published Schedule-at-a-Glance. The timetable lays out the structure of this year’s digital format and lists the proposed times for scientific sessions, keynote speaker presentations, networking activities, exhibitor tutorials and more. Note: this schedule is tentative and may be adjusted as details solidify. Stay tuned to SLAS communication channels for updates. VIEW SLAS2021 SCHEDULE AT A GLANCE

Last Chance to Submit Your SLAS2021 Digital Presentation/Live Talk Abstracts SLAS Monday, September 14 is the final day to submit an abstract for an opportunity to present during SLAS2021 Digital and the opportunity to earn a Tony B. Academic Award. Plus, all submitters can opt-in to compete for the $10,000 SLAS Innovation Award, which recognizes exceptional and innovative research presented in a live talk. Submissions chosen for the Innovation Award competition will be presented in dedicated sessions throughout the three-day conference. Additional POSTER deadlines are listed below: Tony B. Academic Award poster submission deadline: Monday, October 5 Student Poster Competition abstract submission deadline: Monday, October 19 Poster abstract submission deadline: Monday, January 11 All members of the SLAS community are encouraged to submit an abstract for presentation or poster while students, graduate students, post-doctoral associates and junior faculty (less than four years in first academic appointment) are encouraged to apply for the Tony B. Academic Award program. VIEW COMPLETE CALL FOR ABSTRACTS DETAILS

A CRISPR Conversion: Jumping from Gene Editing to Life-Saving Detection During the COVID-19 Crisis SLAS Three years ago, SLAS Transformed presenter and Mammoth Biosciences chief technology officer Janice Chen, Ph.D., and lab partner Lucas Harrington, Ph.D., uncovered something unique in their CRISPR research – a different “flavor” of the protein from the Cas12 family that had ideal properties for nucleic acid detection. This discovery led to the idea of developing CRISPR-based diagnostics for real-world utility, which resulted not only in the creation of Mammoth Biosciences, but also led to their development of a new COVID-19 diagnostic that can address needs across a continuum of testing using CRISPR proteins. READ MORE

SPONSORED VIDEO The Ultimate Laboratory Microplate Mover The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner. WATCH VIDEO

Part One of September's Live Webinar Series on Cancer Research Begins Tomorrow SLAS Registration is still open for tomorrow’s live webinar, “Redefining Pre-Clinical Testing in Oncology: Why We Need to Go 3D.” This is the first in a series of three live webinars focusing on cancer drug discovery topics such as the use of 3D cellular models in pre-clinical testing and drug screening, and how patient-derived scaffolds can be used to simulate microenvironments. REGISTER NOW

Registration is open for the two remaining webinars in this series: Tuesday, September 15, 7:00 a.m. (2:00 p.m. CET): The Roadmap for the Next Generation Oncology: The Contribution of Tridimensional Models Tuesday, September 22, 7:00 a.m. (2:00 p.m. CET): Patient Derived Scaffolds (PDS) in Cancer Research and Drug Discovery Registration is FREE for SLAS members and $20 for all others. REGISTER NOW

Mentors Invited to Pay it Forward with SLAS Mentor Match Program SLAS Help guide professionals in their life sciences and technology careers. The SLAS Mentor Match program was developed to provide a connection point for mentors to share knowledge and give support to mentees who in turn benefit from engaging with industry leaders and seasoned scientists at all stages of their career. Enrolling as a mentor or mentee is free, but participants must be SLAS members. ENROLL AS A MENTOR

PRODUCT SHOWCASE Accelerate biologics development Introducing the BioXp™ 3250 system, a fully automated synthetic biology workstation. It dramatically reduces the timelines for identifying antibody and vaccine candidates from weeks to days by assembling DNA clones, libraries, and gene fragments — as long as 7,000 base pairs — in a single overnight run. LEARN MORE

Last Call for Emerging Trends in 3D Cell Culture Research SLAS Next Tuesday, September 15 is the final day to submit research pertaining to emerging trends in 3D cell culture for the opportunity to be published in an upcoming SLAS Technology special issue. Suggested topics for the 2021 release include: high-throughput screening, disease modeling and translational medicine. This particular special issue is sponsored by Corning Life Sciences and is expected to make a large impact within the three topical areas. Do not miss this opportunity to get involved! COMPLETE SUBMISSION DETAILS

Calendar of Important Dates SLAS On-Demand Training Pharmacological Target Engagement Available September 14 SLAS2021 Digital International Conference and Exhibition – Call for Abstracts Deadline is Monday, September 14! January 25 – 27, 2021 View live talk and poster abstract submission details September Webinar Series Redefining Pre-Clinical Testing in Oncology: Why We Need to Go 3D September 10 7:00 a.m. CDT Speaker: Marina Simian Ph.D., Principal Investigator, Instituto de Nanosistemas, Universidad Nacional de San Martín The Roadmap for the Next Generation Oncology: The Contribution of Tridimensional Models September 15 7:00 a.m. CDT Speaker: Virginia Brancato, Ph.D., Assistant Researcher, 3Bs Research Group - University of Minho Patient Derived Scaffolds (PDS) in Cancer Research and Drug Discovery September 22 7:00 a.m. CDT Speaker: Göran Landberg, M.D., Ph.D., Professor, University of Gothenburg Rescheduled from August: Compound-Mediated Interferences in Homogeneous Proximity Assays September 25 11:00 a.m. CDT Speaker: Jayme L. Dahlin, M.D., Ph.D., Postdoctoral Fellow, Brigham and Women’s Hospital, Harvard Medical School

SPONSORED CONTENT Promoted by Corning • E-book Download: All About Organoids • Video: Using Organoids for Personalized Medicine: An Interview with Sylvia Boj from HUB • Harnessing Next-Generation Cell Culture Methods in the Fight Against Cancer • Modeling Kidney Disease with Bioengineered Kidney Organoids • Webinar Series: Organoid Masterclasses

HEADLINES

Crystalline and Stable Benzofuran-Linked Covalent Organic Frameworks From Irreversible Cascade Reactions Journal of the American Chemical Society Researchers report the synthesis of crystalline two-dimensional covalent organic frameworks by connecting hydroxybenzene-aldehyde and acetonitrile building blocks to form cyano-substituted benzofuran linkages. Unlike the majority of COFs that were synthesized based on condensation reactions, the COFs in this report are crystallized from irreversible cascade reactions involving consecutive cyanide migration, ring-closure, and oxidation reactions. READ MORE

Panel Lays Out Guidelines for CRISPR-Edited Human Embryos The Scientist On Sept. 3, the International Commission on the Clinical Use of Human Germline Genome Editing released a report that reviews the available research and determines gene editing’s ethical use on human embryos. The 225-page document offers a roadmap to the testing and regulations necessary to develop the technology and ultimately concludes that the technology is not yet reliable enough to use on humans. READ MORE

FEATURED ARTICLE Drug screening in patient tumor micro environment Promoted by Iscaffpharma Sortina Pharma use Iscaffpharma’s patient derived scaffolds to create drug fingerprints and select drugs for aggressive cancer. Read Case READ MORE

New Method, IDMSeq, Quantifies CRISPR-Cas9 Edits Genetic Engineering & Biotechnology News Understanding, and quantifying, the genetic heterogeneity of a cell population is essential to the understanding of biological systems. Although new technologies are being developed to do this, in particular in the field of early cancer detection, the majority of current sequencing techniques lack the sensitivity to detect rare mutations in a pool of cells. Researchers have now developed an approach—targeted individual DNA molecule sequencing—that can accurately detect a single mutation in a pool of 10,000 cells. READ MORE

Stable SARS-CoV-2 Genome Is Good News for Vaccine Developers Chemical & Engineering News While researchers are developing and testing vaccines for SARS-CoV-2, the coronavirus that causes COVID-19, the virus is mutating and evolving as it moves from person to person. To understand if those mutations will affect the effectiveness of vaccines, researchers at the Walter Reed Army Institute of Research and the Fred Hutchinson Cancer Research Center analyzed over 18,500 different SARS-CoV-2 genomes. Their findings should be reassuring for vaccine developers. READ MORE

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Researchers Perform Energy Audit of Human Cells Lab Manager TK Adenosine triphosphate, or ATP, is the cellular energy currency that is as valuable to the human body as the dollar is to the US economy. Too high or too low levels of ATP in some cell types have been linked to a variety of diseases. However, scientists have lacked an understanding of how cells regulate ATP levels on a broad scale and how cells' energy levels can be protected or restored in the setting of disease. READ MORE

New Structural Unit Simplifies the Process of Custom-Designing Proteins Phys.org A pair of researchers at the University of California, San Francisco, has developed a new protein structure that allows for simplifying the process of custom-designing proteins. In their paper published in the journal Science, Nicholas Polizzi and William DeGrado discuss their structural unit and how they used it. Anna Peacock, with the University of Birmingham, has published a Perspective piece outlining the work by the team in California in the same journal issue. READ MORE

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Giant Leap for Molecular Measurements Science Daily Spectroscopy is an important tool of observation in many areas of science and industry. Infrared spectroscopy is especially important in the world of chemistry where it is used to analyze and identify different molecules. The current state-of-the-art method can make approximately 1 million observations per second. UTokyo researchers have greatly surpassed this figure with a new method about 100 times faster. READ MORE

Commission Charts Narrow Path for Editing Human Embryos Science Magazine No recent biomedical experiment has caused more consternation than He Jiankui’s creation of the first gene-edited babies, in 2018, which was widely seen as dangerous, unethical, and premature—and which led to his incarceration by China. Now, an international committee has concluded that gene-editing methods, despite substantial improvements, are still far from mature enough to safely introduce heritable DNA modifications into human embryos. READ MORE

Measure cAMP Signaling in Live Cells Use cADDis to measure cAMP through Gs or Gi signaling in real time. Easily detectable on plate readers & imaging systems Bright green or red fluorescent readout High signal-to-noise ratio MORE INFO

CAREER CONNECTIONS

Job Seekers: Post your résumé and sign up for new job alerts by keyword. Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings. Scientific Director SLAS US – IL – Oak Brook Research Assistant- Genetics, Genomics, and Informatics University of Tennessee Health Science Center US – TN – Memphis Postdoctoral Research Position in Immunology at UCLA University of California, Los Angeles US – CA – Los Angeles Search Jobs at SLAS Career Connections

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