This message contains images. If you don't see images, click here to view. Advertise in this news brief.    Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 10, 2014 SLAS.org    SLAS2015    Moving? New job? Let SLAS know.     Advertisement Advertisement Advertisement Advertisement Advertisement Providing clean, uninterrupted electrical power. Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.   Advertisement Grad Students, Post-Docs and Junior Faculty: Submit Poster Abstracts by Sept. 22 and You Could Earn Free Travel to SLAS2015 SLAS    Share    Students, graduate students, post-doctoral associates and junior faculty are invited to submit poster abstracts for SLAS2015 and the SLAS Tony B. Academic Travel Award program. Those selected will receive airfare, full conference registration, hotel accommodations and the opportunity to participate fully in the premier conference for laboratory science and technology professionals. SLAS2014 Student Poster Competition and Tony B. Award winner Tim Ruckh talks about the benefits of conference attendance, including career counseling opportunities, in a short video. More Advertisement NEW at JBS Online: Improving Detection of Rare Biological Events in High-Throughput Screens SLAS    Share    A team from Canada, including SLAS2015 Short Course instructor Robert Nadon, reports: "The success of high-throughput screening (HTS) strategies depends on the effectiveness of both normalization methods and study design. We report comparisons among normalization methods in two titration series experiments. We also extend the results in a third experiment with two differently designed but otherwise identical screens: compounds in replicate plates were either placed in the same well locations or were randomly assigned to different locations. Best results were obtained when randomization was combined with normalization methods that corrected for within-plate spatial bias. We conclude that potent, reliable, and accurate HTS requires replication, randomization design strategies, and more extensive normalization than is typically done and that formal statistical testing is desirable." More Advertisement Profile Cell Health with multiplexed MultiCyt reagents [Application Note] Multiplexing with Membrane Integrity, Cell Cycle, and Immunophenotyping Endpoints [Application Note] MultiCyt QBeads for High Throughput Cytokine Profiling in Human Peripheral Blood Mononuclear Cells [Webinar Replay] High Throughput Flow – Enabling Multiplexed, Miniaturized Cell & Bead-Based Assays Register for Sept. 23 Ultra-High Throughput Flow Cytometry SLAS Webinar SLAS    Share    "We are all tasked with finding new drugs that can differentiate our companies and provide real benefit to patients," says John Joslin, research investigator at the Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA. In the SLAS Webinar, "Development of a Fully Automated Ultra-High-Throughput Flow Cytometry Screening System to Enable Novel Drug Discovery," Joslin describes how this Novartis solution accelerates the drug discovery progress. Dues-paid SLAS members can join the webinar live at 11:30 EDT on Sept. 23, or access the recording at a later date, for free. More information is available in the SLAS Electronic Laboratory Neighborhood e-zine article on the topic. More Advertisement New! CellTiter-Glo® 2.0 Assay Same high performance as the original assay, now provided as a single reagent— ready-to-use with storage stability at 4°C or room temperature. No mixing. Now thawing. No waste. Try a FREE sample today in your lab. Advertisement Cloud Solutions Designed with Scientists in Mind Save time and money with    Acquire™ lab supplies    management software. Streamline compound    management with Store™ Make internal and external    compounds and assays    accessible to all project    teams with Request™ Visualize™ enables    securely sharing compound    and biological assay results. 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Three SLAS Short Courses Sept. 26 in Basel, Switzerland SLAS    Share    Following great support for SLAS Short Courses at the recently held ELRIG Drug Discovery 2014, SLAS presents a short course program in collaboration with the Swiss Biotech Association at the Pullman Hotel Basel on Friday, Sept. 26. 3D Cell-based Assays for Drug De-risking Presented by Markus Rimann of Zurich University of Applied Sciences; and Simon Messner of InSphero AG Label-Free/Biophysics Methods for Screening Presented by Christine Genick of Novartis Institutes for Biomedical Research; Jörg Weiske of Bayer; and Timothy Sharpe of University of Basel Applied Information Technology for the Laboratory Presented by Burkhard Schaefer of BSSN Software More New Short Course at SLAS2015: Digital Image Processing and Analysis SLAS    Share    "Digital Image Processing and Analysis for the Laboratory Scientist: Theory and Application" will be held Sunday, Feb. 8. This SLAS2015 Short Course, one of seven new or re-engineered conference short courses, takes a practical, hands-on approach to the application of digital image processing and analysis. Participants will learn image capture best practices, gain a better understanding of image processing fundamentals and how image processing algorithms function, learn to use powerful, freely available image processing tools to analyze experimental images, become skilled at authoring methods for extracting and measuring key features from images, explore how to automate the processing of large numbers of image files using scripting and learn to summarize measurements, compute statistics and visualize results. Matthew Fronheiser, Bristol-Myers Squibb Co., and Mark Russo, Rowan University, are course instructors. Image courtesy of Anand Krishnan, 2013 JALA & JBS Art of Science Contest. More SPONSORED CONTENT Access our screening libraries to advance your target into lead discovery Run a 2 million compound screen against your target, in AstraZeneca’s HTS facility Screen our fragment library against your innovative drug target, in your own lab Receive an award up to $100,000 for target validation Find out more about Open Innovation opportunities with AstraZeneca Apply for NCATS' Small Business Contract Funding by Nov. 5 NCATS    Share    Through its Small Business Innovation Research (SBIR) program, the National Center for Advancing Translational Sciences (NCATS) is participating in 2015 contract funding opportunities for qualified applicants interested in developing innovative health technologies. Topics of interest to NCATS are: NCATS 007: Exploring the Potential of CRISPR/CAS Genome-editing Tools (page 76) NCATS 009: Assay Development for High-Throughput Screening of Chemicals of Toxicological Concern (page 77) NCATS 341: Simple and Robust Reaction Progress Analyzer (page 78) NCATS 342: Online Real Time Metals Analysis at Low ppm (page 79) Proposals must be submitted by Nov. 5 at 4:30 p.m. Eastern Time. In advance of the deadline, contact sean.dalenberg@nih.gov with notice of your intent to submit or for additional information. More 2014 Salaries and Employment Chemical & Engineering News    Share    Unemployment is easing in the U.S. economy as a whole, and that trend is reflected in the chemical sector, according to the latest figures compiled by the American Chemical Society. "The unemployment rate of our domestic chemistry workforce is once again under 3.0 percent, as it was prior to the economic downturn of 2008–09," notes Elizabeth C. McGaha, assistant director of ACS's Research & Brand Strategy department, which collects the data. More Advertisement In Directing Stem Cells, Study Shows Context Matters Bioscience Technology    Share    Figuring out how blank slate stem cells decide which kind of cell they want to be when they grow up — a muscle cell, a bone cell, a neuron — has been no small task for science. Human pluripotent stem cells, the undifferentiated cells that have the potential to become any of the 220 types of cells in the body, are influenced in the lab dish by the cocktail of chemical factors and proteins upon which they are grown and nurtured. More Imaging without Fluorescence: Nonlinear Optical Microscopy for Quantitative Cellular Imaging Analytical Chemistry    Share    Quantitative single-cell analysis enables the characterization of cellular systems with a level of detail that cannot be achieved with ensemble measurement. In this Feature we explore quantitative cellular imaging applications with nonlinear microscopy techniques. We first offer an introductory tutorial on nonlinear optical processes and then survey a range of techniques that have proven to be useful for quantitative live cell imaging without fluorescent labels. More Advertisement Introducing BAMS: Bead-Assisted Mass Spectrometry BAMS brings a new paradigm to mass spectrometry by combining bead-based multiplexing and plate-based self-assembly. Available Now by Early Access! Click Here. Advertisement CLARIOstar innovative microplate reader BMG LABTECH’s most innovative microplate reader with advanced LVF Monochromators™. No longer choose performance over flexibility with this powerful and versatile reader. FDA Approves New Melanoma Drug that Turns on the Immune System to Fight Deadly Cancers Lab Manager    Share    The U.S. Food and Drug Administration recently approved a new immunotherapy drug to treat advanced melanoma, signaling a paradigm shift in the way the deadly skin cancer is treated. The drug, Keytruda, was tested on more than 600 patients who had melanoma that had spread throughout their bodies. Because so many of the patients in the early testing showed significant long-lasting responses, the study was continued and the FDA granted the drug "breakthrough therapy" status. More Advertisement Tips for Establishing Successful Cell-Based Assays: Part 3 Multispan, Inc.     Share    Cell Culture Maintenance and Propagation For successful and reproducible cell culture assays, it is imperative that cells be maintained and propagated in a consistent manner to minimize genetic and non-genetic changes due to selection, genetic drift or contamination. Typically, cell medium and propagation schedule information accompanies the cell purchase. In general the conditions described below should be used initially. Be sure to keep a cell log on each cell type and collect information such as medium and dissociation solution, passage number and any other observations. Typically, the general maintenance protocols are as follows for adherent cells. More Promoted by Multispan, Inc. Diseased Cells Made to Synthesize Their Own Drug Genetic Engineering & Biotechnology News    Share    What if a drug target and a drug synthesis site were one and the same? Such a biochemical twofer would essentially turn a diseased cell into a reaction vessel. A neat trick, to be sure. More important it would, potentially, evade an all-too-familiar problem — the tradeoff between low molecular weight therapeutics (which offer higher permeability) and high molecular weight therapeutics (which offer higher potency). More Nuclear Waste Eaters: Scientists Discover Hazardous Waste-Eating Bacteria Science Daily    Share    Tiny single-cell organisms discovered living underground could help with the problem of nuclear waste disposal, say researchers. Although bacteria with waste-eating properties have been discovered in relatively pristine soils before, this is the first time that microbes that can survive in the very harsh conditions expected in radioactive waste disposal sites have been found. More Researchers Part Water: 'Electric Prism' Separates Water's Nuclear Spin States Phys.org    Share    Using an "electric prism," scientists have found a new way of separating water molecules that differ only in their nuclear spin states and, under normal conditions, do not part ways. Since water is such a fundamental molecule in the universe, the recent study may impact a multitude of research areas ranging from biology to astrophysics. More Human Cells' 'Transport Tracks' Snap Together Like Legos Live Science    Share    When cells divide, protein filmanets called Microtubles transport chromosomes into daughter cells. These filaments are formed when proteins called Tubulin snap together (like legos). After completing the task they fall apart. More Tiny Buckybombs Could Make Bacteria Explode New Scientist    Share    Trying to fight off a virus army? Nanoscale explosives made from spherical carbon molecules could be the answer. Buckyballs, made from 60 carbon atoms arranged like a football, are usually stable. But Vitaly Chaban of the University of Southern Denmark in Odense and his colleagues suspected that adding common explosive ingredients like nitrates could turn them into tiny buckybombs. More Advertisement CLARIOstar innovative microplate reader BMG LABTECH’s most innovative microplate reader with advanced LVF Monochromators™. No longer choose performance over flexibility with this powerful and versatile reader. Filter-like performance, continuously adjustable bandwidths and wavelengths, a dedicated AlphaScreen® laser, UV/Vis spectrometer, and more. For all your assay needs. Advertisement Compact High-Throughput Nucleic Acid Isolation The revolutionary compact chemagic 360 (80 x 65 x 90 cm L/W/H) purifies nucleic acids from 10 µl - 10 ml sample volume by managing 1 96 samples/run. An integrated dispenser for automated buffer filling, QA software and barcode reading allow unique flexibility in sample processing and throughput needs. Advertisement Unlimited Modes of Detection = 1 Microplate Reader With an industry-leading number of detection modes, SpectraMax i3 not only meets your application needs today, it also adapts to your changing requirements tomorrow. Read about the latest microplate reader applications like StainFree Cell Detection and ScanLater Western Blot in the Novel Microplate Reader Applications eBook. Download here >> Professor Pharmacoengineering Department of Biomedical Engineering at UNC and NC State US – NC – Raleigh Health Scientist Administrator (Program Director) NIH/NINDS US – MD – Rockville Assistant Professor Biomedical Microdevices Department of Biomedical Engineering at UNC and NC State US – NC – Chapel Hill More jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! 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