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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 10, 2014

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Grad Students, Post-Docs and Junior Faculty: Submit Poster Abstracts by Sept. 22 and You Could Earn Free Travel to SLAS2015
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Students, graduate students, post-doctoral associates and junior faculty are invited to submit poster abstracts for SLAS2015 and the SLAS Tony B. Academic Travel Award program. Those selected will receive airfare, full conference registration, hotel accommodations and the opportunity to participate fully in the premier conference for laboratory science and technology professionals.

SLAS2014 Student Poster Competition and Tony B. Award winner Tim Ruckh talks about the benefits of conference attendance, including career counseling opportunities, in a short video.
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NEW at JBS Online: Improving Detection of Rare Biological Events in High-Throughput Screens
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A team from Canada, including SLAS2015 Short Course instructor Robert Nadon, reports:

"The success of high-throughput screening (HTS) strategies depends on the effectiveness of both normalization methods and study design. We report comparisons among normalization methods in two titration series experiments. We also extend the results in a third experiment with two differently designed but otherwise identical screens: compounds in replicate plates were either placed in the same well locations or were randomly assigned to different locations. Best results were obtained when randomization was combined with normalization methods that corrected for within-plate spatial bias. We conclude that potent, reliable, and accurate HTS requires replication, randomization design strategies, and more extensive normalization than is typically done and that formal statistical testing is desirable."
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Register for Sept. 23 Ultra-High Throughput Flow Cytometry SLAS Webinar
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"We are all tasked with finding new drugs that can differentiate our companies and provide real benefit to patients," says John Joslin, research investigator at the Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA.

In the SLAS Webinar, "Development of a Fully Automated Ultra-High-Throughput Flow Cytometry Screening System to Enable Novel Drug Discovery," Joslin describes how this Novartis solution accelerates the drug discovery progress. Dues-paid SLAS members can join the webinar live at 11:30 EDT on Sept. 23, or access the recording at a later date, for free.

More information is available in the SLAS Electronic Laboratory Neighborhood e-zine article on the topic.
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    Three SLAS Short Courses Sept. 26 in Basel, Switzerland
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    Following great support for SLAS Short Courses at the recently held ELRIG Drug Discovery 2014, SLAS presents a short course program in collaboration with the Swiss Biotech Association at the Pullman Hotel Basel on Friday, Sept. 26.

    3D Cell-based Assays for Drug De-risking
    Presented by Markus Rimann of Zurich University of Applied Sciences; and Simon Messner of InSphero AG

    Label-Free/Biophysics Methods for Screening
    Presented by Christine Genick of Novartis Institutes for Biomedical Research; Jörg Weiske of Bayer; and Timothy Sharpe of University of Basel

    Applied Information Technology for the Laboratory
    Presented by Burkhard Schaefer of BSSN Software
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    New Short Course at SLAS2015: Digital Image Processing and Analysis
    SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    "Digital Image Processing and Analysis for the Laboratory Scientist: Theory and Application" will be held Sunday, Feb. 8. This SLAS2015 Short Course, one of seven new or re-engineered conference short courses, takes a practical, hands-on approach to the application of digital image processing and analysis.

    Participants will learn image capture best practices, gain a better understanding of image processing fundamentals and how image processing algorithms function, learn to use powerful, freely available image processing tools to analyze experimental images, become skilled at authoring methods for extracting and measuring key features from images, explore how to automate the processing of large numbers of image files using scripting and learn to summarize measurements, compute statistics and visualize results.

    Matthew Fronheiser, Bristol-Myers Squibb Co., and Mark Russo, Rowan University, are course instructors.

    Image courtesy of Anand Krishnan, 2013 JALA & JBS Art of Science Contest.
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    Apply for NCATS' Small Business Contract Funding by Nov. 5
    NCATS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Through its Small Business Innovation Research (SBIR) program, the National Center for Advancing Translational Sciences (NCATS) is participating in 2015 contract funding opportunities for qualified applicants interested in developing innovative health technologies. Topics of interest to NCATS are:
    • NCATS 007: Exploring the Potential of CRISPR/CAS Genome-editing Tools (page 76)
    • NCATS 009: Assay Development for High-Throughput Screening of Chemicals of Toxicological Concern (page 77)
    • NCATS 341: Simple and Robust Reaction Progress Analyzer (page 78)
    • NCATS 342: Online Real Time Metals Analysis at Low ppm (page 79)
    Proposals must be submitted by Nov. 5 at 4:30 p.m. Eastern Time. In advance of the deadline, contact sean.dalenberg@nih.gov with notice of your intent to submit or for additional information.
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    2014 Salaries and Employment
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Unemployment is easing in the U.S. economy as a whole, and that trend is reflected in the chemical sector, according to the latest figures compiled by the American Chemical Society. "The unemployment rate of our domestic chemistry workforce is once again under 3.0 percent, as it was prior to the economic downturn of 2008–09," notes Elizabeth C. McGaha, assistant director of ACS's Research & Brand Strategy department, which collects the data. More

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    In Directing Stem Cells, Study Shows Context Matters
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Figuring out how blank slate stem cells decide which kind of cell they want to be when they grow up — a muscle cell, a bone cell, a neuron — has been no small task for science. Human pluripotent stem cells, the undifferentiated cells that have the potential to become any of the 220 types of cells in the body, are influenced in the lab dish by the cocktail of chemical factors and proteins upon which they are grown and nurtured. More

    Imaging without Fluorescence: Nonlinear Optical Microscopy for Quantitative Cellular Imaging
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Quantitative single-cell analysis enables the characterization of cellular systems with a level of detail that cannot be achieved with ensemble measurement. In this Feature we explore quantitative cellular imaging applications with nonlinear microscopy techniques. We first offer an introductory tutorial on nonlinear optical processes and then survey a range of techniques that have proven to be useful for quantitative live cell imaging without fluorescent labels. More


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    FDA Approves New Melanoma Drug that Turns on the Immune System to Fight Deadly Cancers
    Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The U.S. Food and Drug Administration recently approved a new immunotherapy drug to treat advanced melanoma, signaling a paradigm shift in the way the deadly skin cancer is treated. The drug, Keytruda, was tested on more than 600 patients who had melanoma that had spread throughout their bodies. Because so many of the patients in the early testing showed significant long-lasting responses, the study was continued and the FDA granted the drug "breakthrough therapy" status. More

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    Tips for Establishing Successful Cell-Based Assays: Part 3
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    Cell Culture Maintenance and Propagation
    For successful and reproducible cell culture assays, it is imperative that cells be maintained and propagated in a consistent manner to minimize genetic and non-genetic changes due to selection, genetic drift or contamination. Typically, cell medium and propagation schedule information accompanies the cell purchase. In general the conditions described below should be used initially. Be sure to keep a cell log on each cell type and collect information such as medium and dissociation solution, passage number and any other observations. Typically, the general maintenance protocols are as follows for adherent cells. More

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    Diseased Cells Made to Synthesize Their Own Drug
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    What if a drug target and a drug synthesis site were one and the same? Such a biochemical twofer would essentially turn a diseased cell into a reaction vessel. A neat trick, to be sure. More important it would, potentially, evade an all-too-familiar problem — the tradeoff between low molecular weight therapeutics (which offer higher permeability) and high molecular weight therapeutics (which offer higher potency). More

    Nuclear Waste Eaters: Scientists Discover Hazardous Waste-Eating Bacteria
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Tiny single-cell organisms discovered living underground could help with the problem of nuclear waste disposal, say researchers. Although bacteria with waste-eating properties have been discovered in relatively pristine soils before, this is the first time that microbes that can survive in the very harsh conditions expected in radioactive waste disposal sites have been found. More

    Researchers Part Water: 'Electric Prism' Separates Water's Nuclear Spin States
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Using an "electric prism," scientists have found a new way of separating water molecules that differ only in their nuclear spin states and, under normal conditions, do not part ways. Since water is such a fundamental molecule in the universe, the recent study may impact a multitude of research areas ranging from biology to astrophysics. More



    Human Cells' 'Transport Tracks' Snap Together Like Legos
    Live Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    VideoBrief When cells divide, protein filmanets called Microtubles transport chromosomes into daughter cells. These filaments are formed when proteins called Tubulin snap together (like legos). After completing the task they fall apart. More

    Tiny Buckybombs Could Make Bacteria Explode
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Trying to fight off a virus army? Nanoscale explosives made from spherical carbon molecules could be the answer. Buckyballs, made from 60 carbon atoms arranged like a football, are usually stable. But Vitaly Chaban of the University of Southern Denmark in Odense and his colleagues suspected that adding common explosive ingredients like nitrates could turn them into tiny buckybombs. More


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    Career


    Professor Pharmacoengineering
    Department of Biomedical Engineering at UNC and NC State
    US – NC – Raleigh

    Health Scientist Administrator (Program Director)
    NIH/NINDS
    US – MD – Rockville

    Assistant Professor Biomedical Microdevices
    Department of Biomedical Engineering at UNC and NC State
    US – NC – Chapel Hill

    More jobs at SLAS Career Connections


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