This message contains images. If you don't see images, click here to view. Advertise in this news brief.    Advertisement Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 17, 2014 SLAS.org    SLAS2015    Moving? New job? Let SLAS know.     Advertisement Advertisement Advertisement Advertisement Advertisement Providing clean, uninterrupted electrical power. Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.   Advertisement SLAS ELN Reports: Joshua Kangas — Building an Engine for a Start-up Business SLAS     Share    While still a student, Joshua Kangas, Ph.D., made a life-changing decision. Instead of moving along his planned career path in education, he decided to partner with science and business experts to launch a company that would help enhance the efficiency of drug discovery efforts. Read about Kangas, Quantitative Medicine and the company's Computational Research Engine (CoRE) technology in the SLAS Electronic Laboratory Neighborhood e-zine. More Advertisement SLAS Webinar: Ultra-High Throughput Flow Cytometry on Sept. 23 SLAS     Share    John Joslin, research investigator at the Genomics Institute of the Novartis Research Foundation, describes a fully automated flow cytometry sampling workflow that is compatible with 1536 or 384 well plates. "Our current system can read a 384 well plate in 15 minutes and a 1536 well plate in less than an hour," Joslin states. "This allows for a throughput of approximately 40,000 wells per day with less than one full time employee overseeing the system." Dues-paid SLAS members can join the webinar live Sept. 23 at 11:30 a.m. EDT, or access on demand after the event, for free. More Advertisement Profile Cell Health with multiplexed MultiCyt reagents [Application Note] Multiplexing with Membrane Integrity, Cell Cycle, and Immunophenotyping Endpoints [Application Note] MultiCyt QBeads for High Throughput Cytokine Profiling in Human Peripheral Blood Mononuclear Cells [Webinar Replay] High Throughput Flow – Enabling Multiplexed, Miniaturized Cell & Bead-Based Assays Submit Nominations by Oct. 1 for the 2015 JALA Ten SLAS    Share    "Every year since 2010, JALA has highlighted the top breakthroughs across the fields of automation, drug development, diagnostics, microfluidics, bioengineering, and nanotechnology, among others, which will impact basic and translational research across the academic, government, and industry research sectors," said JALA Editor-in-Chief Dean Ho and JALA Deputy Editor-in-Chief Edward Kai-Hua Chow. Nominations for the 2015 JALA Ten are due Oct. 1 and are open to SLAS members and nonmembers. Self-nominations are welcome. More Congratulations to the Newest SLAS Young Scientist Delegate! SLAS     Share    Graduate student George Burslem, University of Leeds, was named an SLAS Young Scientist Delegate last week at the European Laboratory Robotics Interest Group (ELRIG) Drug Discovery 2014 conference. The student's winning poster was titled "The Design, Synthesis and Evaluation of Inhibitors of the HIF-1α/p300 Protein-Protein Interaction." In conjunction with this distinction, Burslem receives a $500 cash prize, roundtrip coach airfare, shared hotel accommodations and full conference registration for SLAS2015, Feb. 7-11, 2015, Washington, D.C. More Advertisement New! CellTiter-Glo® 2.0 Assay Same high performance as the original assay, now provided as a single reagent— ready-to-use with storage stability at 4°C or room temperature. No mixing. Now thawing. No waste. Try a FREE sample today in your lab. Advertisement Cloud Solutions Designed with Scientists in Mind Save time and money with    Acquire™ lab supplies    management software. Streamline compound    management with Store™ Make internal and external    compounds and assays    accessible to all project    teams with Request™ Visualize™ enables    securely sharing compound    and biological assay results. Advertisement Real-Time Monitoring Cardiomyocyte Beating The xCELLigence RTCA Cardio System monitors cardiomyocyte beating functions in a 96-well format under physiological conditions, using a noninvasive label-free impedance-based technology. Rule out both acute and long-term cardiotoxicity in a single experiment. For more information, please visit www.aceabio.com. JALA Special Issue Call for Manuscript Proposals: Advancing Scientific Innovation with Acoustic Droplet Ejection SLAS    Share    Guest Editors Clive Green, Ph.D.; Lynn Rasmussen; and Joe Olechno, Ph.D., invite manuscript proposals by Oct. 31 on topics related to the use of acoustic droplet ejection (ADE) in drug discovery and the biological sciences. Areas of interest include physics of ADE, ADE in combination drug therapy, ADE in cell-based analyses, ADE in protein crystallography and ADE in combinatorial chemistry. SLAS members and nonmembers alike are welcome to submit proposals. More Laurie Garrett Speaks Out on the Ebola Crisis SLAS    Share    SLAS2015 Keynote Speaker Laurie Garrett was a guest on MSNBC's Melissa Harris-Perry Show on Sept. 7, discussing steps that need be taken to help West Africa. "Here's our opportunity moment," she said, for the U.S. to send supplies, doctors and to educate people in the region about how to protect themselves. Garrett also discussed her Sept. 5 article in Foreign Policy, "We Could Have Stopped This," by applying strategies that had worked in other epidemics. More SPONSORED CONTENT Click here to find out how to access our screening libraries, and our HTS capability Run a large HTS campaign with us Our annotated phenotypic library contains potent actives against >1000 mammalian targets Targeted funding up to $100,000 is available for validation of innovative proposals Got a drug discovery or development idea? AstraZeneca and MedImmune want to partner with you SLAS Tony B. Academic Travel Award Application Deadline is Monday, Sept. 22 SLAS     Share    Reminder! Students, graduate students, post-doctoral associates and junior faculty are invited to submit poster abstracts for SLAS2015 and the SLAS Tony B. Academic Travel Award program. Those selected will receive airfare, full conference registration, hotel accommodations and the opportunity to participate fully in the premier conference for laboratory science and technology professionals. More SLAS Member Meets with Chinese Minister of Science and Technology SLAS     Share    While at the World Economic Forum (WEF) Annual Meeting of the New Champions 2014 in Tianjin last week, SLAS Board of Directors member Rich Ellson had the opportunity to meet Wan Gang, Minister of Science and Technology, People's Republic of China (second from left). Ellson was in China to represent Labcyte, which was recognized by WEF as a 2015 Technology Pioneer. More Advertisement Multiple Studies Cite Progress Toward Quality Transcriptomes Genetic Engineering & Biotechnology News    Share    RNA sequencing, a means of depicting the transcriptome, is being used with increasing frequency to characterize a growing array of conditions — everything from prenatal birth defects to disorders of the elderly. Yet the technique, which is a relatively new form of next-generation sequencing, has yet to win the full confidence of patients, clinicians, and researchers. Just how accurate is this form of sequencing? More Protein Courtship Revealed Through Chemist's Lens Phys.org    Share    Staying clear of diseases requires that the proteins in our cells cooperate with one another. But, it has been a well-guarded secret how tens of thousands of different proteins find the correct dancing partners as they degrade and build up the human body, brain and nervous system. A recent breakthrough at the University of Copenhagen's Department of Chemistry has busted down the door and provided a look at the once obscure behavior on the protein dance floor. More Advertisement Introducing BAMS: Bead-Assisted Mass Spectrometry BAMS brings a new paradigm to mass spectrometry by combining bead-based multiplexing and plate-based self-assembly. Available Now by Early Access! Click Here. Advertisement CLARIOstar innovative microplate reader BMG LABTECH’s most innovative microplate reader with advanced LVF Monochromators™. No longer choose performance over flexibility with this powerful and versatile reader. Beckman Coulter Announced as Drug Discovery & Development Scientists' Choice Award Winner Select Science    Share    SelectScience is delighted to announce the Beckman Coulter Biomek® 4000 Laboratory Automation Workstation as the winner of the Scientists' Choice Award for Drug Discovery & Development Product of the Year. The award was presented to Beckman Coulter at the ELRIG Drug Discovery conference, U.K., on Sept. 2. More MipTec, Sept. 23-25, Basel, Switzerland MipTec    Share    "Translating Science into Drugs" is the theme for this MipTec drug discovery and life sciences research conference and exhibition. The event includes scientific sessions and an exhibition. Keynote speakers are Lorenz Mayr of AstraZeneca, Jörg Reinhardt  of Novartis and Patrick Aebischer of Ecole Polytechnique Fédérale de Lausanne. Watch for an announcement of the SLAS Young Scientist Delegate! More Advertisement Tips for Establishing Successful Cell-Based Assays: Part 2 Multispan, Inc.     Share    Standard Cell Culture Practices to Reduce Contamination Risk Most laboratories have rules pertaining to blood-born pathogens. These rules may include mandatory training and certification prior to handling cells, human or non-human, primary or transformed. Be sure you know the rules in detail and follow them. The following is a guide for sources of contamination and ways to avoid them. More Promoted by Multispan, Inc. Astrophysicists to Probe How Early Universe Made Chemical Elements Science Daily    Share    In the beginning, all was hydrogen — and helium, plus a bit of lithium. Three elements in all. Today's universe, however, has nearly a hundred naturally occurring elements, with thousands of variants (isotopes), and more likely to come. Figuring out how the universe got from its starting batch of three elements to the menagerie found today is the focus of a new research project. More Study Links Genetic Mutation to Melanoma Progression Bioscience Technology    Share    Dartmouth researchers have found that the genetic mutation BRAFV600E, frequently found in metastatic melanoma, not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease's progression. Targeting this mutation with Vemurafenib reduces this interaction, and suggests possible new treatment options for melanoma therapy. More Folding-Upon-Binding and Signal-On Electrochemical DNA Sensor with High Affinity and Specificity Analytical Chemistry    Share    Here we investigate a novel signal-on electrochemical DNA sensor based on the use of a clamp-like DNA probe that binds a complementary target sequence through two distinct and sequential events, which lead to the formation of a triplex DNA structure. We demonstrate that this target-binding mechanism can improve both the affinity and specificity of recognition as opposed to classic probes solely based on Watson–Crick recognition. More Ultimate Human Stem Cells Created in the Lab New Scientist    Share    A new type of human stem cell, never seen in nature, has been made in the lab. The cells may be the primordial embryonic cell from which all our cells are created. They should be better at making replacement organs than existing stem cells. "We see it as a blank canvas, the starting point for all tissues in the body," says Austin Smith of the University of Cambridge, who led the team that developed the cells. More Bitter Fruit Bears Protein That Can Act Like Insulin Chemical & Engineering News    Share    Practitioners of traditional medicine have long turned to a knobby green fruit known as bitter melon (Momordica charantia) to treat ailments such as diabetes. Researchers dug into the melon and discovered a protein that binds to and activates the insulin receptor, improving glucose metabolism in diabetic mice. The protein may be a starting point for the development of novel therapies for diabetes, the scientists say. More Keteniminium Ion-Initiated Cascade Cationic Polycyclization Journal of the American Chemical Society    Share    A novel and efficient keteniminium-initiated cationic polycyclization is reported. This reaction, which only requires triflic acid or bistriflimide as promoters, affords a straightforward entry to polycyclic nitrogen heterocycles possessing up to three contiguous stereocenters and seven fused cycles. These complex, polycyclic molecules can be obtained in a single operation from readily available ynamides which were shown to be remarkable building blocks for multiple, consecutive cationic transformations. More Advertisement CLARIOstar innovative microplate reader BMG LABTECH’s most innovative microplate reader with advanced LVF Monochromators™. No longer choose performance over flexibility with this powerful and versatile reader. Filter-like performance, continuously adjustable bandwidths and wavelengths, a dedicated AlphaScreen® laser, UV/Vis spectrometer, and more. For all your assay needs. Advertisement Compact High-Throughput Nucleic Acid Isolation The revolutionary compact chemagic 360 (80 x 65 x 90 cm L/W/H) purifies nucleic acids from 10 µl - 10 ml sample volume by managing 1 96 samples/run. An integrated dispenser for automated buffer filling, QA software and barcode reading allow unique flexibility in sample processing and throughput needs. Advertisement Unlimited Modes of Detection = 1 Microplate Reader With an industry-leading number of detection modes, SpectraMax i3 not only meets your application needs today, it also adapts to your changing requirements tomorrow. Read about the latest microplate reader applications like StainFree Cell Detection and ScanLater Western Blot in the Novel Microplate Reader Applications eBook. Download here >> Senior Research Technologist St. Jude Children's Research Hospital US – TN – Memphis Database Analyst I Childrens Hospital of Philadelphia Center for Autism Research US – PA – Philadelphia Research Engineer USG Corporation US – IL – Libertyville More jobs at SLAS Career Connections   SLAS Point-to-Point Colby Horton, Vice President of Publishing, 469.420.2601 Download media kit Dennis Hall, Executive Editor, 469.420.2656    Contribute news This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free! SLAS Terms of Use Policy Recent issues Sept. 10, 2014 Sept. 3, 2014 Aug. 27, 2014 Aug. 20, 2014 7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063