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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 17, 2014

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SLAS ELN Reports: Joshua Kangas — Building an Engine for a Start-up Business
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While still a student, Joshua Kangas, Ph.D., made a life-changing decision.

Instead of moving along his planned career path in education, he decided to partner with science and business experts to launch a company that would help enhance the efficiency of drug discovery efforts.

Read about Kangas, Quantitative Medicine and the company's Computational Research Engine (CoRE) technology in the SLAS Electronic Laboratory Neighborhood e-zine.
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SLAS Webinar: Ultra-High Throughput Flow Cytometry on Sept. 23
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John Joslin, research investigator at the Genomics Institute of the Novartis Research Foundation, describes a fully automated flow cytometry sampling workflow that is compatible with 1536 or 384 well plates.

"Our current system can read a 384 well plate in 15 minutes and a 1536 well plate in less than an hour," Joslin states. "This allows for a throughput of approximately 40,000 wells per day with less than one full time employee overseeing the system."

Dues-paid SLAS members can join the webinar live Sept. 23 at 11:30 a.m. EDT, or access on demand after the event, for free.
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Submit Nominations by Oct. 1 for the 2015 JALA Ten
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"Every year since 2010, JALA has highlighted the top breakthroughs across the fields of automation, drug development, diagnostics, microfluidics, bioengineering, and nanotechnology, among others, which will impact basic and translational research across the academic, government, and industry research sectors," said JALA Editor-in-Chief Dean Ho and JALA Deputy Editor-in-Chief Edward Kai-Hua Chow. Nominations for the 2015 JALA Ten are due Oct. 1 and are open to SLAS members and nonmembers. Self-nominations are welcome. More

Congratulations to the Newest SLAS Young Scientist Delegate!
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Graduate student George Burslem, University of Leeds, was named an SLAS Young Scientist Delegate last week at the European Laboratory Robotics Interest Group (ELRIG) Drug Discovery 2014 conference.

The student's winning poster was titled "The Design, Synthesis and Evaluation of Inhibitors of the HIF-1α/p300 Protein-Protein Interaction."

In conjunction with this distinction, Burslem receives a $500 cash prize, roundtrip coach airfare, shared hotel accommodations and full conference registration for SLAS2015, Feb. 7-11, 2015, Washington, D.C.
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    JALA Special Issue Call for Manuscript Proposals: Advancing Scientific Innovation with Acoustic Droplet Ejection
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    Guest Editors Clive Green, Ph.D.; Lynn Rasmussen; and Joe Olechno, Ph.D., invite manuscript proposals by Oct. 31 on topics related to the use of acoustic droplet ejection (ADE) in drug discovery and the biological sciences.

    Areas of interest include physics of ADE, ADE in combination drug therapy, ADE in cell-based analyses, ADE in protein crystallography and ADE in combinatorial chemistry.

    SLAS members and nonmembers alike are welcome to submit proposals.
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    Laurie Garrett Speaks Out on the Ebola Crisis
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    SLAS2015 Keynote Speaker Laurie Garrett was a guest on MSNBC's Melissa Harris-Perry Show on Sept. 7, discussing steps that need be taken to help West Africa.

    "Here's our opportunity moment," she said, for the U.S. to send supplies, doctors and to educate people in the region about how to protect themselves.

    Garrett also discussed her Sept. 5 article in Foreign Policy, "We Could Have Stopped This," by applying strategies that had worked in other epidemics.
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    SLAS Tony B. Academic Travel Award Application Deadline is Monday, Sept. 22
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    Reminder! Students, graduate students, post-doctoral associates and junior faculty are invited to submit poster abstracts for SLAS2015 and the SLAS Tony B. Academic Travel Award program.

    Those selected will receive airfare, full conference registration, hotel accommodations and the opportunity to participate fully in the premier conference for laboratory science and technology professionals.
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    SLAS Member Meets with Chinese Minister of Science and Technology
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    While at the World Economic Forum (WEF) Annual Meeting of the New Champions 2014 in Tianjin last week, SLAS Board of Directors member Rich Ellson had the opportunity to meet Wan Gang, Minister of Science and Technology, People's Republic of China (second from left).

    Ellson was in China to represent Labcyte, which was recognized by WEF as a 2015 Technology Pioneer.
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    Multiple Studies Cite Progress Toward Quality Transcriptomes
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    RNA sequencing, a means of depicting the transcriptome, is being used with increasing frequency to characterize a growing array of conditions — everything from prenatal birth defects to disorders of the elderly. Yet the technique, which is a relatively new form of next-generation sequencing, has yet to win the full confidence of patients, clinicians, and researchers. Just how accurate is this form of sequencing? More

    Protein Courtship Revealed Through Chemist's Lens
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Staying clear of diseases requires that the proteins in our cells cooperate with one another. But, it has been a well-guarded secret how tens of thousands of different proteins find the correct dancing partners as they degrade and build up the human body, brain and nervous system. A recent breakthrough at the University of Copenhagen's Department of Chemistry has busted down the door and provided a look at the once obscure behavior on the protein dance floor. More


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    Beckman Coulter Announced as Drug Discovery & Development Scientists' Choice Award Winner
    Select Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    SelectScience is delighted to announce the Beckman Coulter Biomek® 4000 Laboratory Automation Workstation as the winner of the Scientists' Choice Award for Drug Discovery & Development Product of the Year. The award was presented to Beckman Coulter at the ELRIG Drug Discovery conference, U.K., on Sept. 2. More

    MipTec, Sept. 23-25, Basel, Switzerland
    MipTec    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    "Translating Science into Drugs" is the theme for this MipTec drug discovery and life sciences research conference and exhibition. The event includes scientific sessions and an exhibition. Keynote speakers are Lorenz Mayr of AstraZeneca, Jörg Reinhardt  of Novartis and Patrick Aebischer of Ecole Polytechnique Fédérale de Lausanne. Watch for an announcement of the SLAS Young Scientist Delegate! More

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    Tips for Establishing Successful Cell-Based Assays: Part 2
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    Astrophysicists to Probe How Early Universe Made Chemical Elements
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    In the beginning, all was hydrogen — and helium, plus a bit of lithium. Three elements in all. Today's universe, however, has nearly a hundred naturally occurring elements, with thousands of variants (isotopes), and more likely to come. Figuring out how the universe got from its starting batch of three elements to the menagerie found today is the focus of a new research project. More

    Study Links Genetic Mutation to Melanoma Progression
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Dartmouth researchers have found that the genetic mutation BRAFV600E, frequently found in metastatic melanoma, not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease's progression. Targeting this mutation with Vemurafenib reduces this interaction, and suggests possible new treatment options for melanoma therapy. More

    Folding-Upon-Binding and Signal-On Electrochemical DNA Sensor with High Affinity and Specificity
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Here we investigate a novel signal-on electrochemical DNA sensor based on the use of a clamp-like DNA probe that binds a complementary target sequence through two distinct and sequential events, which lead to the formation of a triplex DNA structure. We demonstrate that this target-binding mechanism can improve both the affinity and specificity of recognition as opposed to classic probes solely based on Watson–Crick recognition. More



    Ultimate Human Stem Cells Created in the Lab
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A new type of human stem cell, never seen in nature, has been made in the lab. The cells may be the primordial embryonic cell from which all our cells are created. They should be better at making replacement organs than existing stem cells. "We see it as a blank canvas, the starting point for all tissues in the body," says Austin Smith of the University of Cambridge, who led the team that developed the cells. More

    Bitter Fruit Bears Protein That Can Act Like Insulin
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Practitioners of traditional medicine have long turned to a knobby green fruit known as bitter melon (Momordica charantia) to treat ailments such as diabetes. Researchers dug into the melon and discovered a protein that binds to and activates the insulin receptor, improving glucose metabolism in diabetic mice. The protein may be a starting point for the development of novel therapies for diabetes, the scientists say. More

    Keteniminium Ion-Initiated Cascade Cationic Polycyclization
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A novel and efficient keteniminium-initiated cationic polycyclization is reported. This reaction, which only requires triflic acid or bistriflimide as promoters, affords a straightforward entry to polycyclic nitrogen heterocycles possessing up to three contiguous stereocenters and seven fused cycles. These complex, polycyclic molecules can be obtained in a single operation from readily available ynamides which were shown to be remarkable building blocks for multiple, consecutive cationic transformations. More


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