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Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.
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See how the Thermo Scientific Versette automated liquid handler can meet your liquid handling needs!
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Boost your career or find the perfect candidate. SLAS Career Connections offers both online and in-person career services.
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Interactive e-zine sharing experiences and perspectives on science-related topics. Send article ideas to eln@slas.org.
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 SLAS members discuss lab-on-a-chip technology
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George Whitesides, Gary Kramer, Elliot Hui and Kevin Hrusovsky share thoughts on the chasm often experienced between academic research and commercial development of products.
"Researchers need to think about the difference between a measurement in a scientific paper and a product that is a solution to a problem," Whitesides notes. "Both are interesting and probably required for the progress of science. However, if you make lots of things that make really great papers, but nobody ever uses them, it's a bit sterile."
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 Next week: David Swinney presents SLAS Webinar on phenotypic drug discovery
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Swinney's Sept. 26 presentation is the first of three in the 2013 Fall SLAS Webinar Series, Phenotypic and Signaling Network Approaches as an Alternative to Target-Based Drug Discovery. Swinney will discuss the challenges and solutions to assimilating molecular and phenotypic approaches to increase drug discovery success. The webinar is FREE to dues-paid SLAS members and sponsored by Cellular Dynamics International. SLAS Biomolecular Sciences Section members and JBS subscribers can view new, original Swinney research now at JBS Online.
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JALA Online features new manuscripts ahead-of-print
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"Hybrid Microfabrication of Nanofiber-Based Sheets and Rods for Tissue Engineering Applications" and "Pressure-Driven Microfluidic Perfusion Culture Device for Integrated Dose-Response Assays" are among the new manuscripts available only to SLAS Laboratory Automation Section members and JALA subscribers ahead-of-print.
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It's easy to keep your fitness routine at SLAS2014!
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A picturesque running route or a power-packed "100 steps to the top" workout are just two of the ways to stay on track at SLAS2014. The beautiful San Diego location is much appreciated by SLAS runners like Ioana Popa-Burke. Both the Hilton San Diego Bayfront and San Diego Marriott Marquis & Marina have impressive fitness centers and pools. Pack your favorite step-recording wireless device to track your steps, especially while exploring the SLAS2014 Exhibit Hall!
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Stay connected through SLAS social media forums
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Get involved in SLAS LinkedIn (main group and 18 subgroups), Facebook and Twitter for discussion, ideas, solutions, shout outs, requests and more. The new SLAS Electronic Laboratory Neighborhood e-zine Facebook page grew to nearly 1,600 followers in its first month.
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Let Multispan be your one-stop shop partner from cell line and
assay development to screening, lead optimization and
profiling - reduce your cycle time to IND.
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Whether your lab is manual, semi-automated or fully automated, FlexLink has flexible conveyor systems and solutions that fit perfectly where space is limited and close machine interface is required.
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MipTec 2013 is next week in Basel, Switzerland
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SLAS presents four speakers at MipTec 2013, Sept. 24-26:
Nanobiopharmaceuticals: Helping Complex Molecules to Reach their Targets
M.J. Alonso, University of Santiago de Compostela, Santiago de Compostela, ES
Peptide Therapeutics Track
The Signaling Networks Regulating Cell Shape
C. Bakal, The Institute of Cancer Research, London, UK
High Content Screening Track
Adapting Human Pluripotent Stem Cells to High Content Screening: Challenges and Applications
S. Desbordes, Helmholtz Zentrum, Munich, DE
High Content Screening Track
Peptides as Drugs, An Academical Point of View
J. Martinez, University of Montpellier, Montpellier, FR
Peptide Therapeutics Track
SLAS also will invite the winner of the MipTec student poster competition to SLAS2014 as part of the SLAS Young Scientist Delegate program.
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Dualsystems Biotech is a provider of custom proteomics services for industry and academia, specializing in ligand-receptor capture, affinity purification/mass spectrometry analysis of protein complexes and stable cell line generation.
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The xCELLigence RTCA Cardio System monitors cardiomyocyte beating functions in a 96-well format under physiological conditions, using a noninvasive label-free impedance-based technology. Rule out both acute and long-term cardiotoxicity in a single experiment. For more information, please visit www.aceabio.com.
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Get results fast with Hamamatsu’s FDSS µCELL, an imaging-based microplate reader. This affordable, simple-to-use reader accommodates 96- or 384-well microplates for kinetic cell-based assays such as GPCR, ion channel, prolyl isomerase, transporter, and light-activated receptor or channel assays. Click here for more info.
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New findings challenge assumptions about origins of life
Lab Manager Share
Before there was life on Earth, there were molecules. A primordial soup. At some point a few specialized molecules began replicating. This self-replication, scientists agree, kick-started a biochemical process that would lead to the first organisms. But exactly how that happened — how those molecules began replicating — has been one of science's enduring mysteries. Now, research from University of North Carolina at Chapel Hill School of Medicine biochemist Charles Carter, PhD, offers an intriguing new view on how life began.
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Key HIV entry point analyzed
Chemical & Engineering News Share
For the first time, the structure of the receptor that is the predominant entry point for the AIDS virus to invade human cells has been determined. Knowing the form of the receptor, called CCR5, raises hopes for the discovery of drugs that can block human immunodeficiency virus more effectively than can the drug maraviroc. When HIV infects someone, it first interacts with CD4 receptors on immune-cell surfaces.
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Human stem cell-derived hepatocytes regenerate liver function
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Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase survival of the treated animals. This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease relied on the development of scalable, reproducible methods to produce stem cell-derived hepatocytes in bioreactors, as described in an article in Stem Cells and Development.
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Scigilian is a software company specializing in offering solutions to the problems encountered in pharmaceutical research, biotechnology, and contract research. Trusted, from large pharma to small CRO.
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Molecular structure reveals how HIV infects cells
Bioscience Technology Share
In a long-awaited finding, a team of Chinese and U.S. scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. The researchers also showed where maraviroc, an HIV drug, attaches to cells and blocks HIV's entry. "These structural details should help us understand more precisely how HIV infects cells, and how we can do better at blocking that process with next-generation drugs," says professor Beili Wu.
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Enzyme-catalyzed oxidation facilitates the return of fluorescence for single-walled carbon nanotubes
Journal of the American Chemical Society Share
In this work, we studied enzyme-catalyzed oxidation of single-walled carbon nanotubes (SWCNTs) produced by the high-pressure carbon monoxide (HiPco) method. While oxidation via strong acids introduced defect sites on SWCNTs and suppressed their near-infrared (NIR) fluorescence, our results indicated that the fluorescence of SWCNTs was restored upon enzymatic oxidation, providing new evidence that the reaction catalyzed by horseradish peroxidase (HRP) in the presence of H2O2 is mainly a defect-consuming step.
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Girl who feels no pain could inspire new painkillers
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A girl who does not feel physical pain has helped researchers identify a gene mutation that disrupts pain perception. The discovery may spur the development of new painkillers that will block pain signals in the same way. People with congenital analgesia cannot feel physical pain and often injure themselves as a result — they might badly scald their skin, for example, through being unaware that they are touching something hot.
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Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro
Proceedings of the National Academy of Sciences Share
Deciphering the multifactorial determinants of tumor progression requires standardized high-throughput preparation of 3D in vitro cellular assays. We present a simple microfluidic method based on the encapsulation and growth of cells inside permeable, elastic, hollow microspheres. We show that this approach enables mass production of size-controlled multicellular spheroids. Due to their geometry and elasticity, these microcapsules can uniquely serve as quantitative mechanical sensors to measure the pressure exerted by the expanding spheroid.
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Sodium-ion battery cathode has highest energy density to date
Phys.org Share
Although sodium-ion (Na-ion) batteries don't perform as well as lithium-ion (Li-ion) batteries, they have the potential to be a cheaper alternative. In a new study, scientists have designed a new cathode for Na-ion batteries that provides an energy density of 600 Wh kg-1, which is the highest reported so far for Na-ion batteries and even rivals the energy densities of some Li-ion batteries.
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Scientists use 'wired microbes' to generate electricity from sewage
Science Daily Share
Engineers at Stanford University have devised a new way to generate electricity from sewage using naturally-occurring "wired microbes" as mini power plants, producing electricity as they digest plant and animal waste. In a paper published today in the Proceedings of the National Academy of Sciences, co-authors Yi Cui, a materials scientist, Craig Criddle, an environmental engineer, and Xing Xie, an interdisciplinary fellow, call their invention a microbial battery.
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BMG LABTECH is releasing its newest instrument, the CLARIOstar, a high performance microplate reader with advanced monochromators, spectrometer, and filters. With this cutting-edge, hybrid technology, the CLARIOstar offers clear superiority with unparalleled flexibility and sensitivity.
Anything is possible with BMG LABTECH’s CLARIOstar. Any wavelength. Any bandwidth. Any assay.
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Introducing AusWasher MTP, a plate washer with residual volume < 0.01µl, enabling the highest specificity ELISA in 96, 384,1536 well plates with dramatically reduced number of wash steps. Centrifugation eliminates aspiration of wash buffer: no clogging, uniform buffer removal, no damage from physical contact with needles. Available standalone and OEM.
Info: Wolfgang Mann wmann@ausbio.de
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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