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  Mobile version   RSS   Subscribe   Unsubscribe   Archive   Media Kit Sep. 18, 2013    SLAS2014    Moving? New job? Let SLAS know.    







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The SLAS Electronic Laboratory Neighborhood

Interactive e-zine sharing experiences and perspectives on science-related topics. Send article ideas to




SLAS members discuss lab-on-a-chip technology
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George Whitesides, Gary Kramer, Elliot Hui and Kevin Hrusovsky share thoughts on the chasm often experienced between academic research and commercial development of products.

"Researchers need to think about the difference between a measurement in a scientific paper and a product that is a solution to a problem," Whitesides notes. "Both are interesting and probably required for the progress of science. However, if you make lots of things that make really great papers, but nobody ever uses them, it's a bit sterile."


Next week: David Swinney presents SLAS Webinar on phenotypic drug discovery
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Swinney's Sept. 26 presentation is the first of three in the 2013 Fall SLAS Webinar Series, Phenotypic and Signaling Network Approaches as an Alternative to Target-Based Drug Discovery. Swinney will discuss the challenges and solutions to assimilating molecular and phenotypic approaches to increase drug discovery success. The webinar is FREE to dues-paid SLAS members and sponsored by Cellular Dynamics International. SLAS Biomolecular Sciences Section members and JBS subscribers can view new, original Swinney research now at JBS Online. More

Sponsored Content

JALA Online features new manuscripts ahead-of-print
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"Hybrid Microfabrication of Nanofiber-Based Sheets and Rods for Tissue Engineering Applications" and "Pressure-Driven Microfluidic Perfusion Culture Device for Integrated Dose-Response Assays" are among the new manuscripts available only to SLAS Laboratory Automation Section members and JALA subscribers ahead-of-print. More


It's easy to keep your fitness routine at SLAS2014!
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A picturesque running route or a power-packed "100 steps to the top" workout are just two of the ways to stay on track at SLAS2014. The beautiful San Diego location is much appreciated by SLAS runners like Ioana Popa-Burke. Both the Hilton San Diego Bayfront and San Diego Marriott Marquis & Marina have impressive fitness centers and pools. Pack your favorite step-recording wireless device to track your steps, especially while exploring the SLAS2014 Exhibit Hall! More

Stay connected through SLAS social media forums
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Get involved in SLAS LinkedIn (main group and 18 subgroups), Facebook and Twitter for discussion, ideas, solutions, shout outs, requests and more. The new SLAS Electronic Laboratory Neighborhood e-zine Facebook page grew to nearly 1,600 followers in its first month. More

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MipTec 2013 is next week in Basel, Switzerland
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SLAS presents four speakers at MipTec 2013, Sept. 24-26:

Nanobiopharmaceuticals: Helping Complex Molecules to Reach their Targets
M.J. Alonso, University of Santiago de Compostela, Santiago de Compostela, ES
Peptide Therapeutics Track

The Signaling Networks Regulating Cell Shape
C. Bakal, The Institute of Cancer Research, London, UK
High Content Screening Track

Adapting Human Pluripotent Stem Cells to High Content Screening: Challenges and Applications
S. Desbordes, Helmholtz Zentrum, Munich, DE
High Content Screening Track

Peptides as Drugs, An Academical Point of View
J. Martinez, University of Montpellier, Montpellier, FR
Peptide Therapeutics Track

SLAS also will invite the winner of the MipTec student poster competition to SLAS2014 as part of the SLAS Young Scientist Delegate program.

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Real-Time Monitoring Cardiomyocyte Beating
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Add-and-Read Plate Reader
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New findings challenge assumptions about origins of life
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Before there was life on Earth, there were molecules. A primordial soup. At some point a few specialized molecules began replicating. This self-replication, scientists agree, kick-started a biochemical process that would lead to the first organisms. But exactly how that happened — how those molecules began replicating — has been one of science's enduring mysteries. Now, research from University of North Carolina at Chapel Hill School of Medicine biochemist Charles Carter, PhD, offers an intriguing new view on how life began. More


Key HIV entry point analyzed
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For the first time, the structure of the receptor that is the predominant entry point for the AIDS virus to invade human cells has been determined. Knowing the form of the receptor, called CCR5, raises hopes for the discovery of drugs that can block human immunodeficiency virus more effectively than can the drug maraviroc. When HIV infects someone, it first interacts with CD4 receptors on immune-cell surfaces. More


Human stem cell-derived hepatocytes regenerate liver function
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Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase survival of the treated animals. This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease relied on the development of scalable, reproducible methods to produce stem cell-derived hepatocytes in bioreactors, as described in an article in Stem Cells and Development. More

Scigilian Software, Inc.
Scigilian is a software company specializing in offering solutions to the problems encountered in pharmaceutical research, biotechnology, and contract research. Trusted, from large pharma to small CRO.
Dualsystems Biotech AG
Dualsystems Biotech is a provider of custom screening services for industry and academia, specializing in yeast two-hybrid, CaptiVate AP/MS-MS and cDNA library construction.

Molecular structure reveals how HIV infects cells
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In a long-awaited finding, a team of Chinese and U.S. scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. The researchers also showed where maraviroc, an HIV drug, attaches to cells and blocks HIV's entry. "These structural details should help us understand more precisely how HIV infects cells, and how we can do better at blocking that process with next-generation drugs," says professor Beili Wu. More

Enzyme-catalyzed oxidation facilitates the return of fluorescence for single-walled carbon nanotubes
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In this work, we studied enzyme-catalyzed oxidation of single-walled carbon nanotubes (SWCNTs) produced by the high-pressure carbon monoxide (HiPco) method. While oxidation via strong acids introduced defect sites on SWCNTs and suppressed their near-infrared (NIR) fluorescence, our results indicated that the fluorescence of SWCNTs was restored upon enzymatic oxidation, providing new evidence that the reaction catalyzed by horseradish peroxidase (HRP) in the presence of H2O2 is mainly a defect-consuming step. More


Girl who feels no pain could inspire new painkillers
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A girl who does not feel physical pain has helped researchers identify a gene mutation that disrupts pain perception. The discovery may spur the development of new painkillers that will block pain signals in the same way. People with congenital analgesia cannot feel physical pain and often injure themselves as a result — they might badly scald their skin, for example, through being unaware that they are touching something hot. More

Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro
Proceedings of the National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Deciphering the multifactorial determinants of tumor progression requires standardized high-throughput preparation of 3D in vitro cellular assays. We present a simple microfluidic method based on the encapsulation and growth of cells inside permeable, elastic, hollow microspheres. We show that this approach enables mass production of size-controlled multicellular spheroids. Due to their geometry and elasticity, these microcapsules can uniquely serve as quantitative mechanical sensors to measure the pressure exerted by the expanding spheroid. More

Sodium-ion battery cathode has highest energy density to date    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Although sodium-ion (Na-ion) batteries don't perform as well as lithium-ion (Li-ion) batteries, they have the potential to be a cheaper alternative. In a new study, scientists have designed a new cathode for Na-ion batteries that provides an energy density of 600 Wh kg-1, which is the highest reported so far for Na-ion batteries and even rivals the energy densities of some Li-ion batteries. More

Scientists use 'wired microbes' to generate electricity from sewage
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Engineers at Stanford University have devised a new way to generate electricity from sewage using naturally-occurring "wired microbes" as mini power plants, producing electricity as they digest plant and animal waste. In a paper published today in the Proceedings of the National Academy of Sciences, co-authors Yi Cui, a materials scientist, Craig Criddle, an environmental engineer, and Xing Xie, an interdisciplinary fellow, call their invention a microbial battery. More

BMG LABTECH Introduces The CLARIOstar
BMG LABTECH is releasing its newest instrument, the CLARIOstar, a high performance microplate reader with advanced monochromators, spectrometer, and filters. With this cutting-edge, hybrid technology, the CLARIOstar offers clear superiority with unparalleled flexibility and sensitivity.

Anything is possible with BMG LABTECH’s CLARIOstar. Any wavelength. Any bandwidth. Any assay.
Low residual volume plate washing
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Head of Department
France – Croissy-sur-seine

Senior Research Fellow – Principal Investigator
United States

QC Scientist – Protein Analytical Chemistry (Validation)
US – CA – South San Francisco

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