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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 20, 2017    SLAS2018    Moving? New job? Let SLAS know.      




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Last Call! SLAS2018 Poster Abstracts Due Sept. 25 for Tony B. Academic Travel Award Consideration
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The Tony B. Academic Travel Award is one way SLAS ensures that up-and-coming researchers who demonstrate outstanding achievement can learn from and interact with practicing life sciences discovery and technology community leaders. If selected for a Tony B. Award at SLAS2018 (Feb. 3-7 in San Diego, CA), travel, hotel accommodations and conference registration are provided to the primary author of a submitted podium or poster abstract.

Since SLAS was founded in 2010, SLAS Tony B. Academic Travel Awards have provided funding to enable 337 students, post-docs and early career professionals from around the world to participate in this SLAS International Conference and Exhibition.


Free SLAS Webinar on 3D Assays: Next Tuesday, Sept. 26
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Brad Larson of BioTek Instruments and Mark Rothenberg of Corning Life Sciences share their expertise on the cellular microenvironment and its importance when developing and screening cell-based assays using primary, stem cell and immortalized cultures in 3D systems. "3-Dimensional Assays: What Must Be Done for Setting Up and Validating for Downstream Microplate Reader and Imaging Applications" will be presented live Sept. 26 and then available on demand.

This SLAS Webinar is open to members and non-members alike. For more on the topic, tune into SLAS Past President Richard Eglen's webinar on Sept. 22, "New Technologies for Cellular Research: 3-Dimensional Cell Culture and Screening."


Promoted by Surmodics

Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules That Exhibit Functional Synergy with Potentiators and Correctors
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NEW and FREE at SLAS Discovery — this Proteostasis Therapeutics, Inc. (Cambridge, MA) study reports the results of a "high-throughput screen aimed at identifying novel first-in-class small molecules that exhibit functional synergy in combination with ivacaftor and lumacaftor (VX-809) and do not necessarily function as potentiators or correctors themselves. One of the active series identified, represented by PTI-CH, was shown to possess novel characteristics relative to known modulators. This newly identified class of CFTR (cystic fibrosis transmembrane conductance regulator) modulators, which we have termed amplifiers, may advance our understanding of cystic fibrosis biology and, more important, be a promising candidate as a therapy for patients with cystic fibrosis."

This is a SAGE Choice article, allowing all readers immediate free access to the full manuscript.

Call for Papers: High-Throughput Flow Cytometry in Drug Discovery
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SLAS Discovery Guest Editors Mei Ding of AstraZeneca and Bruce S. Edwards of the University of New Mexico invite special issue manuscript proposals (abstracts) on high-throughput flow cytometry (HTFC) applications for drug discovery or target discovery; HTFC for antibody generation screening, biomarker discovery, biochemical applications; HTFC using multiplexing approaches; HTFC as an alternative for other assay platforms; insights and opinions on HTFC assay design and development; novel assays using HTFC; reagent developments for HTFC applications; developments in HTFC instruments and automation; and advances in HTFC data analysis software.

Proposal due date is Oct. 1.

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3D Printing for Scientific Applications: Get Started with a Practical, Hands-On Short Course
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Mark Russo, Ph.D., associate director in computational genomics, and Matthew Fronheiser, Ph.D., medical imaging analyst lead, both from Bristol-Myers Squibb, have teamed up to teach a new course at SLAS2018.

"3D printing has gone from an interesting curiosity to a viable tool in various segments of science and industry. Yet it's still rare enough that few scientists have actually had a chance to get close up to the technology," said Steve Hamilton, Ph.D., SLAS director of education.

Russo and Fronheiser share their knowledge and experience regarding 3D printed custom labware, prototype design and molecular models in the SLAS Electronic Laboratory Neighborhood e-zine.

Register Now for SLAS2018
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SLAS Premier Members should register by Oct. 31 to take advantage of the best rates for participation from Feb. 3-7 as SLAS2018 returns to San Diego. SLAS2018 features peer-selected educational programming, hands-on access to technology and intelligent peer networking. The scientific program is being finalized and includes three new educational tracks — Biologics Discovery, Chemical Biology and High-Definition Biotechnology.

SLAS2018 Short Course
descriptions and faculty information are available now. Not yet an SLAS member? Become one today and enjoy year-round member benefits through the end of 2018. Take advantage of the "Invite a Colleague" button on the registration page to let others know about SLAS2018.



Highly Active, Nonprecious Electrocatalyst Comprising Borophene Subunits for the Hydrogen Evolution Reaction
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Developing nonprecious hydrogen evolution electrocatalysts that can work well at large current densities (e.g., at 1000 mA/cm2: a value that is relevant for practical, large-scale applications) is of great importance for realizing a viable water-splitting technology. Herein we present a combined theoretical and experimental study that leads to the identification of α-phase molybdenum diboride (α-MoB2) comprising borophene subunits as a noble metal-free, superefficient electrocatalyst for the hydrogen evolution reaction. More

Microparticles Created by New 3-D Fabrication Method Could Release Drugs or Vaccines Long After Injection    Share    Share on FacebookTwitterShare on LinkedinE-mail article
MIT engineers have invented a new 3-D fabrication method that can generate a novel type of drug-carrying particle that could allow multiple doses of a drug or vaccine to be delivered over an extended time period with just one injection. The new microparticles resemble tiny coffee cups that can be filled with a drug or vaccine and then sealed with a lid. The particles are made of a biocompatible, FDA-approved polymer that can be designed to degrade at specific times, spilling out the contents of the "cup." More

Sponsored Content

CRISPR Identifies Rare Type of Glycosylation Critical for Cancer
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at the University of Georgia say they have shown that a rare type of glycosylation greatly affects the function of a protein important for human development and cancer progression. Protein glycosylation, N-linked or O-linked, depends on whether a sugar is attached to nitrogen- or oxygen-containing sites, respectively. The research team of Robert Haltiwanger, Ph.D., has studied specific O-linked modifications, i.e., the attachment of glucose or fucose to serine or threonine, a modification that affects only a few hundred different types of proteins, including one called Notch. More

Doubts Raised Over Validity of CRISPR-Edited Human Embryo Study
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Last month, an international team reported using CRISPR/Cas9 gene-editing techniques to remove a common genetic mutation from human embryos that causes the heart condition hypertrophic cardiomyopathy. Now, experts in embryology and genetics are calling that report into question. In the initial study, published Aug. 2 in Nature, researchers led by Shoukhrat Mitalipov of Oregon Health & Science University claimed they used CRISPR to correct a mutation in the MYBPC3 gene introduced into embryos by a sperm donor's DNA. More

KMC Systems Engineering & Manufacturing

KMC Systems is a leading provider of engineering services and contract manufacturing for the development, design and production of medical and life sciences instrumentation. We specialize in developing mechanized processes for tightly controlled and highly automated systems and manufacturing complex, highly-regulated instruments for the clinical environment.

Sensitive Analysis of Nitroguanidine in Aqueous and Soil Matrices by LC-MS
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Nitroguanidine, a widely used nitramine explosive, is an environmental contaminant that is refractory, persistent, highly mobile in soils and aquifers, and yet under-researched. Nitroguanidine determination in water and soil poses an analytical challenge due its high hydrophilicity, low volatility, charge neutrality over a wide pH range, and low proton affinity which results in low electrospray interface-MS sensitivity. A sensitive method for the determination of nitroguanidine in aqueous and soil matrices was developed. More

Novel Genetic Mutation Discovered in Parkinson's Disease Patient
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Mutations in the human genome may be responsible for many diseases. In the case of Parkinson's disease, five locations have been the subject of recent attention. Variants of one of these locations, ACMSD (aminocarboxymuconate semialdehyde decarboxylase), may be implicated in PD, but until now, no mutations in ACMSD have been found in any Parkinson's patients. In a study in the Journal of Parkinson's Disease, researchers found a unique mutation in a 74-year-old man with Parkinson's. More

Scientists Combine Antimalarial Drug with Light Sensitive Molecules for Promising Treatment of Cancer
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Artemisinin, a potent anti-malarial drug, has been widely hailed as a promising alternative cancer treatment. Scientists from the National University of Singapore recently showed that its anti-cancer properties could be enhanced by 10 folds when used in combination with Aminolaevulinic acid, a photosensitiser or a drug which, upon exposure to light, leads to generation of free radicals that can kill cells. More

Test Strips for Cancer Detection Get Upgraded With Nanoparticle Bling
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The most common test strip people might think of for diagnosis is a home pregnancy test. Pregnant women have steadily increasing levels of the biomarker human chorionic gonadotropin, which is easily detectable in urine and a thin, colorful strip of antibodies will appear when hCG is present. However, there's a lot more hCG in pee than there is of cancer biomarkers in blood. More


Research Technician I – Preclinical Imaging
Cold Spring Harbor Laboratory
US – NY – Cold Spring Harbor

Associate Scientist, Histology
US – CA – San Diego

Manager of Pharmaceutical Development
Camargo Pharmaceutical Services
US – OH – Cincinnati or Raleigh-Durham

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