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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit September 24, 2014

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Innovation AveNEW Applications Due Oct. 10
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The unique SLAS Innovation AveNEW program fosters emerging talent and technology by providing start-up companies with complimentary exhibit space, full conference registration, travel and hotel accommodations at the annual SLAS conference and exhibition.

Entrepreneurs interested in being considered for Innovation AveNEW slots at SLAS2015 must apply by Friday, Oct. 10; a panel of volunteer judges reviews technical merit and commercial feasibility.
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Screening by RNAi and Precise Genome Editing Technologies
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Manuscript proposals (abstracts) are still being considered for this special issue of the Journal of Biomolecular Screening (JBS). Of special interest are papers about commercially available RNAi libraries and related platforms, process development and validation for RNAi screening, screening data analysis and bioinformatic filtering, use of genome editing tools such as ZFN, TALENS and CRISPR for hit validation and phenotype confirmation in multiple cell models, and target validation for drug discovery. More

SLAS Nominations Committee is at Work
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The SLAS Nominations Committee, chaired by Rich Ellson of Labcyte, is in the process of selecting three individuals who will join the SLAS Board of Directors for three-year terms of service beginning in February 2015.

Candidate applications for the SLAS Board of Directors are being accepted from the membership through October 10. All candidates must have the capacity and commitment to serve, and meet the required criteria outlined in the SLAS Strategic Plan, SLAS Board of Directors Selection Policy and the SLAS Bylaws.

The new board members will replace Frank Fan, Robyn Rourick and Daniel G. Sipes.
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SLAS Americas Regional Council Holds Inaugural Meeting at SLAS Headquarters
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Complementing efforts of the SLAS Europe Regional Council and SLAS Asia Regional Council, the SLAS Americas Council was appointed earlier this year to facilitate regional planning and decision-making.

Last week, the Americas Council met together for the first time in person at SLAS Global Headquarters in St. Charles, IL.

The Council comprises seven life sciences research and development professionals, representing both technology users and providers.
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Francis Collins at TEDMED 2014
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In a Sept. 10 session titled "Flat Out Amazing," NIH Director and SLAS2015 Keynote Speaker Francis Collins summarized "breathtaking" accomplishments emerging in biomedical research — personalized medicine, mobile health technologies and sequencing microbes — and indicated they were "things that I never dreamed would happen in my life span."

Collins speaks at SLAS2015 on Wednesday, Feb. 11 (date change from earlier announcements).
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    From the LabAutopedia Book List — Pharmaplasia
    SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    In Pharmaplasia, Mike Wokasch, a 30-year industry veteran, explores the root causes of the pharmaceutical industry's current state of dysfunction and offers practical solutions for change, even in light of the increasing regulatory constraints, restrictions on marketing and sales and the increasing demands of a cost conscious market driven by healthcare reform. More

    Last Chance to Register for Sept. 26 SLAS Short Courses, Basel, Switzerland
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    The SLAS short course program is being held in collaboration with the Swiss Biotech Association at the Pullman Hotel Basel Friday, Sept. 26.

    3D Cell-based Assays for Drug De-risking
    Presented by Markus Rimann of Zurich University of Applied Sciences; and Simon Messner of InSphero AG

    Label-Free/Biophysics Methods for Screening
    Presented by Christine Genick of Novartis Institutes for Biomedical Research; Jörg Weiske of Bayer; and Timothy Sharpe of University of Basel

    Applied Information Technology for the Laboratory
    Presented by Burkhard Schaefer of BSSN Software
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    Scientists Discover an On/Off Switch for Aging Cells
    R&D Magazine    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at the Salk Institute have discovered an on-and-off "switch" in cells that may hold the key to healthy aging. This switch points to a way to encourage healthy cells to keep dividing and generating, for example, new lung or liver tissue, even in old age. In our bodies, newly divided cells constantly replenish lungs, skin, liver and other organs. More

    Finding Supports Model on Cause of DNA's Right-handed Double Helix
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The DNA of every organism on Earth is a right-handed double helix, but why that would be has puzzled scientists since not long after Francis Crick and James Watson announced the discovery of DNA's double-helical structure in 1953. It's a puzzle because no one has been able to think of a fundamental reason why DNA couldn't also be left-handed. More

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    Scientists Report Reliable and Highly Efficient Method for Making Stem Cells
    Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at NYU Langone Medical Center have found a way to boost dramatically the efficiency of the process for turning adult cells into so-called pluripotent stem cells by combining three well-known compounds, including vitamin C. Using the new technique in mice, the researchers increased the number of stem cells obtained from adult skin cells by more than 20-fold compared with the standard method. More

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    Tips for Establishing Successful Cell-Based Assays: Part 3
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    Cell Culture Maintenance and Propagation
    For successful and reproducible cell culture assays, it is imperative that cells be maintained and propagated in a consistent manner to minimize genetic and non-genetic changes due to selection, genetic drift or contamination. Typically, cell medium and propagation schedule information accompanies the cell purchase. In general the conditions described below should be used initially. Be sure to keep a cell log on each cell type and collect information such as medium and dissociation solution, passage number and any other observations. Typically, the general maintenance protocols are as follows for adherent cells. More

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    Engineered Proteins Stick Like Glue — Even in Water
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers have found new adhesives based on mussel proteins could be useful for naval or medical applications. To create their new waterproof adhesives, researchers engineered bacteria to produce a hybrid material that incorporates naturally sticky mussel proteins as well as a bacterial protein found in biofilms — slimy layers formed by bacteria growing on a surface. More

    The Quest for New Antibiotics Turns Back to Nature, Genetics
    By Rosemary Sparacio    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    With antibiotic resistance becoming an increasing problem in medical treatment, the search is on for new antibiotics, new sources for those antibiotics and new mechanisms. For thousands of years people have used products found in nature for their medicinal properties. A return to nature may be the next area in which we find antibiotics. Smaller pharmaceutical companies are still pursuing research and manufacturing, and they are submitting regulatory documents for new antibiotics to the FDA for their approval. But perhaps more promising is the work being done to look for novel mechanisms and to explore different areas in the search. More


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    Folding-Upon-Binding and Signal-On Electrochemical DNA Sensor with High Affinity and Specificity
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Here we investigate a novel signal-on electrochemical DNA sensor based on the use of a clamp-like DNA probe that binds a complementary target sequence through two distinct and sequential events, which lead to the formation of a triplex DNA structure. We demonstrate that this target-binding mechanism can improve both the affinity and specificity of recognition as opposed to classic probes solely based on Watson–Crick recognition. More

    Stem Cells Used in Landmark Therapy for Failing Sight
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A woman in Japan has received the first medical treatment based on induced pluripotent stem cells, eight years after they were discovered. The iPS cells were made by reprogramming skin cells from the woman's arm, then transformed into specialised eye cells to treat age-related macular degeneration (AMD) — a condition that affects millions of elderly people worldwide, and often results in blindness. More

    New Study Furthers Development of Drugs Targeting Potassium-ion Channels
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    In the field of drug development, frequent targets are cell-membrane proteins, such as ion channels, tiny pores that allow various substances to enter and exit the cell. Ion channels, which govern the passage of sodium, potassium and calcium ions, play a key role in many physiological functions, such as the nerve impulse (and hence the entire nervous system), muscle contraction and insulin secretion. More



    Pushing the Limits of Chemical Bonding
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Chemical bonding "is the heart of chemistry," according to Alexander I. Boldyrev, a chemistry professor at Utah State University who spends his time thinking about how molecules are put together. "But it is still not well-defined. We need to develop the breadth of the concept and make it as rigorous as we can, yet as simple as we can, so it is more powerful and more useful." More

    Reuleaux Triangle Disks: New Shape on the Block
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    We report here the unprecedented preparation of Reuleaux triangle disks. The hydrolysis and precipitation of bismuth nitrate in an ethanol-water system with 2,3-bis(2-pyridyl)pyrazine yielded basic bismuth nitrate Reuleaux triangle disks. Analysis of the intermediates provided insights into the mystery behind the formation of the Reuleaux triangle disk, revealing a unique growth process. More

    New Technique Produces Higher Quality Pluripotent Stem Cells
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at the Hebrew University of Jerusalem report the development of a new cocktail that effectively coaxes adult cells to become quality stem cells. The resulting induced pluripotent stem cells (iPSCs) could be used to replace those lost to damage or disease. However, the process of reprogramming adult cells can introduce genetic abnormalities that limit the cells' usefulness in research and medicine. More


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    Career


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