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SLAS
The internet of things (IoT) is allowing scientists to optimize laboratory operations and combine instruments to measure and respond to complex experimental conditions. As a result, IoT is enabling more detailed and more complex experimental designs. A new special issue of SLAS Technology, The Internet of Things in the Life Sciences Laboratory, showcases life sciences researchers who are pioneering the use of powerful yet accessible and low-cost IoT technologies in their laboratories. Ten articles illustrate how IoT is being used to optimize factors such as throughput, cost, uptime and result quality. An SLAS Technology podcast is available online and features special issue Guest Editor James M. Gill, II, Ph.D., of BFL Consulting (Madison, CT, USA).
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SLAS
In a new column in the SLAS Electronic Laboratory Neighborhood e-zine, SLAS President Sabeth Verpoorte, Ph.D., ponders new beginnings as registration opens for the SLAS2019 International Conference and Exhibition. "Who will be selected as podium presenters in the 10 tracks? What new products will be showcased at the Exhibition? Who might I meet this year that may be the perfect collaborator on my current projects? The possibilities are endless," Verpoorte says.
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SLAS
A new auto-commentary published in SLAS Technology looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can be used to improve drug development and personalized medicine. Available for free for a limited time, the article builds on a study recently published by the authors in Science Translational Medicine about an artificial intelligence (AI) platform, Quadratic Phenotypic Optimization Platform (QPOP), that substantially improves combination therapy in bortezomib-resistant multiple myeloma to identify the best drug combinations for individual multiple myeloma patients. Illustration by Zac Goh.
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Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report , learn how viDA Therapeutics streamlined their processes and improved collaboration.
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SLAS
Tap into the experience, insights and capabilities of peers and complementary organizations at the SLAS Ignite Collaboration Presentations to be held during SLAS2019 (Feb. 2-6, 2019, at the Walter E. Washington Convention Center in Washington, DC, USA). The 15-minute podium presentations, selected by a review committee based on the quality of submitted abstracts, shine a spotlight on collaborative partnerships for:
- Scientists from industry,
- Academic researchers, and
- Business development professionals (from industry or academia) whose responsibilities include finding, funding and formalizing research partnerships.
Could your research or your search for new partners be the next to catch fire? Applications for the SLAS Ignite Collaboration Presentations are due Monday, Oct. 15.
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SLAS
Join a rousing point/counterpoint presentation with Bhagyashree Khunte, M.Sc., MBA, of Pfizer (Groton, CT, USA) and Jeff Chin of BMS (Hopewell, NJ, USA), as they examine "New Tech Bypassing Traditional CM." Taking control of the topic at the 2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic, the duo delve into obstacles and opportunities surrounding traditional compound management strategies versus a new paradigm in which technology enables the distribution of newly synthesized compounds directly to the assay. "No one solution will fit all projects and that's why the point/counterpoint format is valuable for this topic. We have the opportunity to explore both sides of the issue," Khunte comments in a recent article that appears in the SLAS Electronic Laboratory Neighborhood. Read the complete scientific program! Register before Monday, Oct. 1 to save $150. Reserve your hotel room early if you plan to attend. Rooms at the Omni Parker House are filling up for this event, and the group rate is offered based on availability.
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
Gain significant visibility for your innovative research by submitting a poster abstract for the 2018 SLAS Advanced 3D Human Models and High-Content Analysis Conference (Oct. 17-19, Leiden, The Netherlands). Of particular interest are novel achievements in 3D culture-enabling technologies, applications of high-throughput microscopy and multiparametric analysis (High Content Screening), advances in imaging and analysis of biological samples and opportunities for stem cells and organoids. Poster abstracts due Thursday, Oct. 4.
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Journal of the American Chemical Society
Laboratory time scale evolution in vivo relies on the generation of large, mutationally diverse gene libraries to rapidly explore biomolecule sequence landscapes. Traditional global mutagenesis methods are problematic because they introduce many off-target mutations that are often lethal and can engender false positives. Researchers report the development and application of the MutaT7 chimera, a potent and highly targeted in vivo mutagenesis agent.
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Chemical & Engineering News
For years, drug developers have followed the "one drug, one target" paradigm: Identify and synthesize a molecule that acts on a single protein or other biological target to treat a specific disease. This approach is costly. On average, it takes at least a decade and $2.6 billion to bring a new drug from lab bench to pharmacy shelf, according to a report from the Pharmaceutical Research & Manufacturers of America.
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AMRI’s integrated drug discovery centers of excellence combine scientific expertise and leading-edge technology to accelerate innovation. Our complete suite of solutions includes comprehensive discovery biology, synthetic and medicinal chemistry, DMPK and bioanalytical services for successful hit-to-lead-to-candidate selection.
Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Science Daily
New drug discovery has long been limited by researchers' inability to precisely control the 3D structure of molecules. But a team led by scientists from The Graduate Center of The City University of New York has made a major breakthrough in chemical synthesis that now makes it possible to quickly and reliably modify the 3D structure of molecules used in drug discovery, according to a paper appearing in the current issue of the journal Science.
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Lab Manager
Researchers from The University of Queensland and the University of Münster have purified and visualized the "Cyclic Electron Flow" supercomplex, a critical part of the photosynthetic machinery in all plants, in a discovery that could help guide the development of next-generation solar biotechnologies.
The findings, made in collaboration with an international team of scientists, have been published in the Proceedings of the National Academies of Sciences.
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Genetic Engineering & Biotechnology News
Researchers at the Salk Institute have described for the first time the molecular structure of CRISPR-Cas13d, an enzyme for emerging RNA-editing technology. They were able to visualize the enzyme with cryo-electron microscopy (cryo-EM) as reported in an article ("Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d") in Cell.
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The Scientist
Three years after its discovery of skeletal stem cells in mice, the same research team has identified the human version of this precursor to bone, cartilage and stroma, the bone marrow's support cells. In a study published in Cell, the authors show that these skeletal stem cells are both self-renewing and multipotent. "For many years there's been this debate about a true human skeletal stem cell. This study unequivocally demonstrates that it's there and that it is self-renewing," says Richard Oreffo, a stem cell biologist.
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Laboratory Equipment
Scientists working to bioengineer the entire human gastrointestinal system in a laboratory now report using pluripotent stem cells to grow human esophageal organoids. Published in the journal Cell Stem Cell, the study is the latest advancement from researchers at the Cincinnati Children's Center for Stem Cell and Organoid Medicine. The center is developing new ways to study birth defects and diseases that affect millions of people with gastrointestinal disorders, such as gastric reflux, cancer and others.
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Phys.org
A team led by Van Andel Research Institute scientists has revealed for the first time the atomic-level structure of TRPM2, a protein that may be a promising drug target for conditions such as Alzheimer's disease and bipolar disorder.
TRPM2 is found throughout the body and is integrally involved in regulating core body temperature, mediating immune responses and governing apoptosis, the programmed death of cells.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Senior Technician – Analytics
Cellectis
France, Paris
Quality Control Development Scientist
Integrated DNA Technologies
US – IA – Coralville
Staff Research Associate II
University of California, Los Angeles
US – CA – Westwood
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