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You Just Have to Start
On this week’s episode of New Matter: Inside the Minds of SLAS Scientists, MJ Wildey, Ph.D., (Merck) helps celebrate the Society’s 10th anniversary by sharing memories over the 26 years she’s been involved and engages in an interesting discussion on the role of screening in the discovery of new disease treatments.
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.SLAS NEWS
SLAS2021 Digital Registration Opens Monday, October 5
SLAS
Get ready: registration for SLAS2021 Digital opens on Monday! While we won’t have the privilege of hosting the 2021 international conference and exhibition in person this January, we will be adapting all of the scientific sessions, keynote addresses, a handful of workshops (scheduled on January 28), new product announcements, awards, networking opportunities (and more!) for a seamless three-day virtual conference with a global-friendly programming schedule and easy to navigate platform. Join the dedicated scientific and technology community for the latest research in drug discovery and lab automation, online January 25-27, 2021.
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New Month, New Live Webinar Series
SLAS
Join SLAS, Hilary Sherman and Constanza Curotto, both of Corning, for the latest live webinar series focusing on 3D assay optimization, organoids and vaccine production and new technologies to fight COVID-19. This series will be spread out over four weeks and is FREE for SLAS Members; $20 for all others. October’s webinar series includes:
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The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner.
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SLAS Journals: A Constant in this Year of Uncertainty
SLAS
In this month’s From the SLAS President, Emilio Diez Monedero reminds readers about what makes the SLAS scientific journals so great: their consistency. Mondedero highlights the recent October SLAS Discovery and SLAS Technology editions along with the special issues that have been released so far in 2020. He also gives a sneak peek at what’s to come in December, namely, a COVID-19-focused special issue of both journals.
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Last Call for SLAS Volunteers
SLAS
If you are looking to get more involved with the SLAS scientific community in your spare time, or add to your resume, visit the SLAS Volunteer Center to check out open volunteer and committee positions. We are currently looking to fill a wide variety of openings on several different councils, committees, judging panels and journal editorial boards designed to fit your schedule and area of expertise. We added a year-round Mentor Match program too, for those who can provide some career advice and coaching to others.
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Introducing the BioXp™ 3250 system, a fully automated synthetic biology workstation. It dramatically reduces the timelines for identifying antibody and vaccine candidates from weeks to days by assembling DNA clones, libraries, and gene fragments — as long as 7,000 base pairs — in a single overnight run.
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Promoted by Iscaffpharma
 Sortina Pharma use Iscaffpharma’s patient derived scaffolds to create drug fingerprints and select drugs for aggressive cancer. Read Case
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.HEADLINES
Dangerous E. coli Strain Reveals Potential New Drug Target
Genetic Engineering & Biotechnology News
Researchers at the University of New South Wales studying an E. coli strain (enterohemorrhagic E. coli or EHEC) that causes a severe intestinal infection in humans, say they discovered a new molecular pathway that controls Shiga toxin production. EHEC is a food-borne pathogen that releases Shiga toxins during infection, resulting in kidney and neurological damage.
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Cryo-Electron Microscopy Reaches Resolution Milestone
Chemical & Engineering News
“It’s like a miracle compared to a few years ago,” says Bridget Carragher, codirector of the Simons Electron Microscopy Center at the New York Structural Biology Center, a research consortium. “It’s quite astonishing.”
Carragher is describing the most detailed portrait to date of a GABAA receptor, a cell membrane protein that is an important target for many drugs.
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Neurological Consequences of COVID-19: The 'Silent Wave'
Lab Manager
Is the world prepared a wave of neurological consequences that may be on its way as a result of COVID-19? This question is at the forefront of research underway at the Florey Institute of Neuroscience and Mental Health. A team of neuroscientists and clinicians are examining the potential link between COVID-19 and increased risk of Parkinson's disease, and measures to get ahead of the curve.
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Aurora is 100% focused on making the highest quality, highest performing Microplates available. We use the best materials, the cleanest and most precise molding operations for our Microplates. We believe that the best Microplates should be an invisible carrier for your work - not a contributor to variability in your data.
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Hidden Immune Weakness Found in 14% of Gravely Ill COVID-19 Patients
Science Magazine
From the first months of the COVID-19 pandemic, scientists baffled by the disease’s ferocity have wondered whether the body’s vanguard virus fighter, a molecular messenger called type I interferon, is missing in action in some severe cases. Two papers published online in Science this week confirm that suspicion. They reveal that in a significant minority of patients with serious COVID-19, the interferon response has been crippled by genetic flaws or by rogue antibodies that attack interferon itself.
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Smart Cells: Chemists Develop Tool With Potential to Treat Illness at the Cellular Level
Science Daily
New research by an international team of chemists describes a new type of artificial cell that can communicate with other cells within the body — with potential applications in the field of smart pharmaceuticals. "In the future, artificial cells like this one could be engineered to synthesizes and deliver specific therapeutic molecules tailored to distinct physiological conditions or illnesses — all while inside the body," explained Sheref Mansy, professor in the University of Alberta's Department of Chemistry.
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Fluorescent 3CLpro/Mpro Inhibitor AssaySARS-CoV-2 Pseudovirus Fluorescent ReporterFluorescent BacMam Host Factors
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Newly Found Alzheimer's Plaque Type Linked to Early-Onset Disease
The Scientist
Scientists have discovered a type of amyloid-β plaque in the brains of people with early-onset Alzheimer’s disease that has not been observed before. These “coarse-grained” plaques, described in a study published last week in Acta Neuropathologica, have a different structure, composition, and distribution from the typical amyloid plaques that have been well-studied in the disease.
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Understanding Oxygen-Reducing Enzymes
Phys.org
Methane is a powerful greenhouse gas that plays a central role in the global carbon cycle. At the same time, it is an important energy source for us humans. About half of its annual production is made by microorganisms known as methanogens that decompose organic material such as dead plants. This normally takes place in a habitat without oxygen as this gas is lethal to methanogens. But even in actually oxygen-free habitats, oxygen molecules occasionally appear.
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Matrigel matrix-3D plates are a pre-coated, convenient, off the shelf option that improve productivity and consistency in homogenous assays where 3D structures are grown and assayed directly in the plate. Using a pre-coated option eliminates the need to handle small volume ECM dispensation and helps reduce workflow steps
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The Cooperative Human Tissue Network (CHTN) is a unique NCI supported resource that provides human tissues and fluids prospectively from surgeries, autopsies and other routine procedures to investigators who utilize human biospecimens in their research. Visit our website for more information and pricing or contact our Central Coordinator.
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.CAREER CONNECTIONS
Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity.
SLAS Premier and Corporate Members get a discount on all new job postings.
Senior Scientist, Biochemical and Cellular Pharmacology
Genentech, Inc.
US – CA – South San Francisco
Associate with AI Machine Learning, Deep Tech and Deep Science Venture Capital Fund, London, UK
PER, Private Equity Recruitment
EU – UK – London
Postdoctoral Research Associate
University of Connecticut
US – CT – Storrs
Search Jobs at SLAS Career Connections
.THANK YOU 2020 SLAS CORPORATE MEMBERS
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