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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit October 4, 2017    SLAS2018    Moving? New job? Let SLAS know.      





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SLAS ELN Reports: Microcontrollers, the Internet of Things and Our Laboratories
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It's been called the second industrial revolution. Whether it's shaping smarter cities, tracking our 10,000 steps a day or just making sure we never run out of laundry detergent, microcontrollers and the Internet of Things are making everyday life ... well, if not simpler, at least a bit more effortless. But how is this technology changing life in the lab? Jay Gill and Erik Werner explore this fascinating topic in the SLAS Electronic Laboratory Neighborhood e-zine feature article. In addition, these IoT enthusiasts invite you to: Gill and Werner are contributing their time and expertise as journal guest editors and short course instructors. More


SLAS Announces Slates for 2018 Board of Directors, Americas Council and Europe Council
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SLAS presents the following professionals for three-year terms of service beginning at SLAS2018:

SLAS Board of Directors

Emilio Diez Monedero, Pharmaceutical Industry Consultant, Madrid, Spain
Peter Brian Simpson, Chief Scientific Officer, Medicines Discovery Catapult, Alderley Park, UK
Severine Tamas-Lhoustau, Co-Founder and Managing Partner, Novoptim, Montigny le Bretonneux, France

SLAS Americas Council
Mike Berke, Director, Research & Automation Technologies, Amgen, Inc., Thousand Oaks, CA
Jonathan O'Connell, Executive Director and Head of Early Discovery, FORMA Therapeutics, Watertown, MA
Joe Olechno, Senior Research Fellow, Labcyte Inc., San Jose, CA

Europe Council
Geert Van Minnebruggen, Head of the Science Policy Unit, VIB, Ghent, Belgium
Ute Vespermann, Drug Discovery Specialist, Corning Inc., Münster, Germany

Pursuant to SLAS policy, if no valid petition nominating alternate candidates for the Board of Directors, Americas Council or Europe Council is received prior to Nov. 1, 2017, the named individuals will be moved forward to the Board for official acclamation in accordance with SLAS Bylaws.


Promoted by Surmodics

New Approaches to Difficult Drug Targets: The Phosphatase Story
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A new review by John S. Lazo et al. of the University of Virginia in the October 2017 issue of SLAS Discovery reflects on the nature of one rather large protein class — protein tyrosine phosphatases — that has been implicated in many human diseases and explores reasons why these enzymes have been eschewed by drug hunters, and how the landscape is beginning to change. The authors place particular emphasis on how automation and innovative screens influence the search for inhibitors and activators of protein tyrosine phosphatases in the area of cancer.

Full access to this review is available to nonmembers for a limited time. Full access always is available to subscribing SLAS Premier members and all Premier Plus members.

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SLAS Webinar Oct. 17: Detecting Small Molecule Non-Covalent Binders Utilizing SAMDI and the Bruker MALDI-TOF — Proof of Concept for a New Screening Format
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Erica C. VanderPorten, SLAS Discovery author and Genentech senior scientific researcher, presents her team's latest work to develop assays to support medicinal chemistry efforts, characterize and understand compound mechanism of action and investigate new lead finding technologies.

"Advances in technology afford the opportunity to revisit old challenges of detecting compound binding from mixtures," VanderPorten says. "We combined the ability of mass spectrometry to unambiguously identify and resolve compounds from complex mixtures of analytes with Self-Assembled Monolayers and matrix-assisted laser Desorption Ionization (SAMDI) technology."

Register for the live webinar (free to dues-paying members) on Oct. 17, and read her SLAS Discovery paper.

New at! On the Road with the SLAS CEO
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"As suggested by the SLAS Board of Directors, I began making visits to SLAS members and vendor partners to learn about your goals and objectives, as well as your challenges," says SLAS CEO Vicki Loise. "In the process, I hope to expand my knowledge of the SLAS community and how the Society might help you meet challenges and business objectives."

Read more about her first stop at Promega headquarters in Madison, WI, and check back regularly as Loise shines a spotlight on SLAS members and their unique stories and experiences.



Printed Meds Could Reinvent Pharmacies, Drug Research
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A technology that can print pure, ultra-precise doses of drugs onto a wide variety of surfaces could one day enable on-site printing of custom-dosed medications at pharmacies, hospitals and other locations. The technique, developed at the University of Michigan, can print multiple medications into a single dose on a dissolvable strip, microneedle patch, or other dosing device. The researchers say it could make life easier for patients who must now take multiple medications every day. More

Nonviral CRISPR Delivery a Success
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While promising, applications of CRISPR-Cas9 gene editing have so far been limited by the challenges of delivery — namely, how to get all the CRISPR parts to every cell that needs them. In a study published in Nature Biomedical Engineering, researchers have successfully repaired a mutation in the gene for dystrophin in a mouse model of Duchenne muscular dystrophy by injecting a vehicle they call CRISPR-Gold, which contains the Cas9 protein, guide RNA, and donor DNA, all wrapped around a tiny gold ball. More

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To Speed CRISPR/Cas9's Search and Snip, Try Extra Cas9 and gRNA
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The CRISPR/Cas9 gene-editing system is advantaged by its targeting mechanism's inherent flexibility, but disadvantaged by this mechanism’s inherent slowness. The mechanism, which depends on a guide RNA (gRNA)-programmable protein, can take a long time to comb through a genome before it finally chances upon a target DNA sequence — up to six hours in a bacterial cell. The problem, say scientists based at Uppsala University, is slow kinetics. More

New Synthesis Method for Click Chemistry
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A recent study, affiliated with UNIST has presented a new way to advance the click chemistry. This is expected to be used in various areas, such as the synthetic chemistry of new drugs, development of functional high-molecules and bio-imaging. In the study, the research team has introduced a new synthetic method to obtain a novel triazole structure, used for the production of drugs and high molecules. More

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Writing on Nanocrystals: Patterning Colloidal Inorganic Nanocrystal Films through Irradiation-Induced Chemical Transformations of Surface Ligands
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In the past couple of decades, colloidal inorganic nanocrystals (NCs) and, more specifically, semiconductor quantum dots (QDs) have emerged as crucial materials for the development of nanoscience and nanotechnology, with applications in very diverse areas such as optoelectronics and biotechnology. Films made of inorganic NCs deposited on a substrate can be patterned by e-beam lithography, altering the structure of their capping ligands and thus allowing exposed areas to remain on the substrate while non-exposed areas are redispersed in a solvent. More

Reinvestigation of Periodate Chemistry Challenges Conventional View
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Periodate — an ion composed of iodine, oxygen, and hydrogen — was studied in water-based solutions extensively from the 1950s to the 1980s. Ever since those studies, chemists have accepted that periodate exists in solution as orthoperiodate (H5IO6) and metaperiodate (IO4) species in equilibrium with each other, along with a dimer (H2I2O104–). More

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Researchers Explore Ways That a Drug Like Avandia Can Be Made Safer    Share    Share on FacebookTwitterShare on LinkedinE-mail article
With the heightened concerns over the dangerous side effects of the once-popular antidiabetic drug Avandia, researchers at The Scripps Research Institute (TSRI) in Jupiter, Florida, are working to understand how small molecules, like those in Avandia, can have such varied effects throughout the body. The insights could help researchers design new drugs with better efficacy and fewer side effects. More

Antibody Protects Against Both Zika and Dengue, Mouse Study Shows
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Brazil and other areas hardest hit by the Zika virus — which can cause babies to be born with abnormally small heads — are also home to dengue virus, which is spread by the same mosquito species. A new study led by researchers at Washington University School of Medicine in St. Louis shows that an antibody that protects against dengue virus is also effective against Zika in mice. More


Molecular Imaging Program Faculty Position
Stanford University
US – CA – Stanford

Director Molecular Genetics and either Cytogenetics or Biochemical Genetics
EGL Genetic Diagnostics, LLC
US – GA – Tucker

Faculty Position in Plant Biotechnology
Massachusetts Institute of Technology
US – MA – Cambridge

Search Jobs at SLAS Career Connections



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