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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit October 08, 2014

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SLAS ELN Reports: Labware Leachables — Unrecognized Contaminants Skew Research Results
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"Leachates may result in false positive or false negative data that misleads researchers in a drug discovery program," says Lynn Rasmussen of Southern Research Institute and chair of the SLAS Labware Leachables Special Interest Group. "False positives usually can be sorted out because the investigators use various assays with different endpoints to confirm a compound"s activity. But false negatives are more problematic because you'll never know what you didn't see."

Learn more from Rasmussen, Walter D. (Lane) Niles of Etaluma and Nils Gerke of Eppendorf in the SLAS Electronic Laboratory Neighborhood e-zine article. Also plan to attend the Labware Leachables SIG meeting at SLAS2015.
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SAGE Journals FREE Trial through Oct. 31
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Register today to receive free online access to more than 1.3 million articles in 750-plus journals from SAGE, including SLAS's two peer-reviewed and MEDLINE-indexed scientific journals. Take advantage of robust search tools to discover interesting and relevant new titles and uncover areas of interest in the literature. Don't currently have full access to SLAS Journal of Biomolecular Screening and Journal of Laboratory Automation? This is your opportunity to see the latest work of your peers. More

SLAS2015 Innovation AveNEW Applications Due Oct. 10
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Start-up companies looking to engage with laboratory science and technology purchasing influencers and decision-makers from more than 40 countries should consider applying by Oct. 10 for a spot on SLAS2015 Innovation AveNEW. If selected, you will receive kiosk exhibit space, travel and lodging for one representative and an opportunity to participate in Late Night with LRIG: Rapid-Fire Innovation Session. More

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SLAS2015 Poster Abstracts Due Oct. 13
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Gain valuable exposure and qualified input on your research if your poster is selected for presentation at SLAS2015, Feb. 7-11, Washington, D.C.

With some 5,000 laboratory scientists and technologists expected to attend, you may obtain that one suggestion that propels your research to the next level.

Submit by Oct. 13 to be sure your participation is confirmed in time for the Oct. 31 early-bird registration deadline.

In addition, students submitting abstracts by Oct. 13 are eligible to enter the Student Poster Competition and a chance to win $500.
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JBS Online Features New Manuscripts Ahead-of-Print
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"Cell-Based Protein Stabilization Assays for the Detection of Interactions between Small-Molecule Inhibitors and BRD4," "Validation and Optimization of Novel High-Throughput Assays for Human Epithelial Sodium Channels" and "Development and Validation of a High-Throughput Anti-Wolbachia Whole-Cell Screen: A Route to Macrofilaricidal Drugs against Onchocerciasis and Lymphatic Filariasis" are new manuscripts posted last week at JBS Online.

These original research articles are available only to SLAS Biomolecular Sciences Section members and JBS subscribers ahead-of-print.
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    New Short Course at SLAS2015: Lab-on-a-Chip — Biomedical Case Studies
    SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    "Lab-on-a-Chip: Biomedical Case Studies" will be held Sunday, Feb. 8, at SLAS2015. This SLAS2015 Short Course, one of seven new or re-engineered conference short courses, is for researchers with an understanding of lab-on-a-chip technologies and who are involved in cutting-edge development in the life sciences.

    Course topics include new technologies for cell studies and assays (acoustofluidics, single-cell analysis, microfluidic cell culture, integrated micro-analytical/microculture systems), bioassays, (stem) cell biology, drug screening and reduction in the use of animals in drug development. Sabeth Verpoorte of the University of Groningen, Johan Nilsson of 
Lund University and Jörg P. Kutter of the University of Copenhagen are course instructors. Image courtesy of Josiane Lafleur, 2014 JALA & JBS Art of Science Contest.
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    SLAS Asia Hosts Antibody Discovery Seminar on Oct. 23
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    The seminar will be held at ShanghaiTech University and includes these sessions:

    Cell Based Hybridoma Screening for Therapeutic Antibody Discovery
    Duan Qing, Principal Scientist, Biologics, Shanghai Chempartner

    A De Novo Antibody Fab Library Using Phage pIX Display
    Lei Shi, Senior Director, Antibody Discovery, RuiYi

    Combinatorial Antibody Library, Theory & Applications
    Guang Yang, Deputy Director, Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
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    Reminder: SLAS Board of Directors Candidate Applications Due Oct. 10
    SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The SLAS Nominations Committee, chaired by Rich Ellson of Labcyte, is in the process of selecting three individuals who will join the SLAS Board of Directors for three-year terms of service beginning early 2015. Check the SLAS website for requirements if you are interested in submitting a candidate application. More

    Last Call: Screening by RNAi and Precise Genome Editing Technologies
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    Manuscript proposals (abstracts) are still being considered for this special issue of the Journal of Biomolecular Screening (JBS). Of special interest are papers about commercially available RNAi libraries and related platforms, process development and validation for RNAi screening, screening data analysis and bioinformatic filtering, use of genome editing tools such as ZFN, TALENS and CRISPR for hit validation and phenotype confirmation in multiple cell models, and target validation for drug discovery. More

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    What Drug-Data Ruling Means for Pharma Firms and You
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Should you have the right to know everything that drug companies know about the medicines you take? Researchers and transparency campaigners have been lobbying the European Medicines Agency, the body that holds this data, to make it publicly available. They argue that holding back drug information makes it hard for patients and doctors to make informed decisions about treatment, and increases the chance that drug trials will be needlessly repeated, wasting money. More

    Researchers Discover a Way to Tease Oxygen Molecules From Carbon Dioxide
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A small team of researchers with the University of California has found a way break apart carbon dioxide molecules and get carbon atoms and oxygen molecules instead of carbon monoxide and an oxygen atom. In their paper published in the journal Science, the team describes how they did it, and the implications of their findings. More


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    Highly Biocompatible Zwitterionic Phospholipids Coated Upconversion Nanoparticles for Efficient Bioimaging
    Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The potential of upconversion nanoparticles in various biomedical applications, including immunoassays, biomedical imaging, and molecular sensing, requires their surface derivatized to be hydrophilic and biocompatible. Here, a new family of compact zwitterionic ligand systems composed with functional phospholipids was designed and used for the surface modification of UCNPs. The zwitterionic UCNPs are hydrophilic, compact, and easily functionalized. More

    First Pictures of BRCA2 Protein Show How it Repairs DNA
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists have taken pictures of the BRCA2 protein for the first time, showing how it works to repair damaged DNA. Mutations in the gene that encodes BRCA2 are well known for raising the risk of breast cancer and other cancers. Although the protein was known to be involved in DNA repair, its shape and mechanism have been unclear, making it impossible to target with therapies. More



    The Immune System Fights Back
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Our bodies are under constant patrol by a vigilant team of defenders. These immune system superheroes set up barriers, decide whether an invader is dangerous, and, when necessary, go to battle. White blood cells called T cells have the crucial task of protecting us from unwelcome pathogens and unhealthy cells. But like all superheroes, T cells have their weaknesses. More

    Graphene May Help Speed Up DNA Sequencing
    Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers from Harvard University and MIT have demonstrated that graphene, a surprisingly robust planar sheet of carbon just one-atom thick, can act as an artificial membrane separating two liquid reservoirs. By drilling a tiny pore just a few nanometers in diameter, called a nanopore, in the graphene membrane, the researchers were able to measure exchange of ions through the pore and demonstrate that a long DNA molecule can be pulled through the graphene nanopore just as a thread is pulled through the eye of a needle. More


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    No Need for Water, Enzymes are Doing It for Themselves
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    New research by scientists at the University of Bristol has challenged one of the key axioms in biology — that enzymes need water to function. The breakthrough could eventually lead to the development of new industrial catalysts for processing biodiesel. Enzymes are large biological molecules that catalyze thousands of different chemical reactions that are essential for all life, from converting food into energy, to controlling how our cells replicate DNA. More

    3-D Triculture Model for Evaluating Breast Cancer Progression
    AMSBIO    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A new application note from AMSBIO, previously presented at both the 2014 Beatson International Cancer conference and the ELRIG Drug Discovery 2014 meeting in Manchester U.K., introduces a more predictive and realistic model for early stage drug screening of cancer therapeutics.
The report shows that incorporating vascular and stromal cells with breast cancer tumor spheroids allows them to more closely mimic the extracellular environment, cellular architecture and behavior of actual tumors; this triculture promotes growth, invasion and endothelial recruitment. More

    AMP 2014 Annual Meeting: Advance Registration Deadline is Oct. 20
    Association for Molecular Pathology     Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The Association for Molecular Pathology 20th anniversary meeting will be held Nov. 12-15 at the Gaylord National Resort & Convention Center, just outside Washington, D.C. Themed "Realizing the Dream of Precision Medicine," the program includes a special address by Francis S. Collins, M.D., Ph.D., plus nearly 400 poster presentations, a premier exhibit hall with 200-plus exhibitors and 60-plus sessions on topics ranging from NGS to infectious disease diagnostics. Register by Oct. 20 and save. More

    Novel Bacterial Genome Roadmap Opens Drug Discovery Pathway
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Scientists at the University of Illinois at Urbana-Champaign and Northwestern University say they have demonstrated the value of an algorithm to analyze microbial genomic data and speed discovery of new therapeutic drugs. A large proportion of the medications used today were discovered by screening bacteria and other organisms for their ability to produce natural products, biologically useful compounds. More

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    Post-doc, Biology of STEP
    Yale University School of Medicine
    US – CT – New Haven

    Director – Institute for Carbon Management
    University of Wyoming
    US – WY – Laramie

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