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SLAS
Exciting news out of London: Jason Swedlow, Ph.D. and Professor of Quantitative Cell Biology at the Centre for Gene Regulation and Expression, (University of Dundee, Scotland) has been announced as this year's keynote speaker. Swedlow will be presenting his group's latest findings on linking genotypes and phenotypes in IDR, and their proposals for next generation data formats and public resources for imaging. Come for the keynote, stay for the numerous discussions on enabling technologies, high-throughput 3D cellular models, advances in imaging and analysis, and complex translational models. Seats are still available for the October 21-22 event.
VIEW FULL SCHEDULE OF EVENTS
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SLAS
Start-ups: there are only two more days to left to submit your application to be featured in Innovation AveNEW at SLAS2020 in San Diego, CA, USA. Do not miss your chance to get extra exposure through this unique exhibition space that highlights emerging companies and their innovative products. Companies who are chosen to have their booth located in Innovation AveNEW, gain maximum exposure to purchasing influencers and decision makers from all over the world. In addition to receiving an exhibit kiosk in Innovation AveNEW, chosen applicants will also benefit from travel and lodging for one representative and a chance to earn the SLAS Ignite Award.
SUBMIT YOUR INNOVATION AVENEW APPLICATION
SLAS
Innovation AveNEW Applications – Friday, October 11
Student Poster Award Competition Abstracts – Tuesday, October 29
Ignite Academic Collaboration Presentation Abstracts (Detailed information coming soon) – October 31
New Product Award (for exhibitors) – Friday, December 13
Poster Abstracts – Monday, January 20
Exhibitor Opportunities
Sponsorship Opportunities
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SLAS
If you were unable to attend last week's AI in Process Automation Symposium, head over to the event page for a quick recap of highlights scribed by Scientific Director Mike Tarselli, Ph.D. For even more content, log in to SLAS APPLIED and download the AI in Process Automation Warmup webinar! (SLAS Premier Members can access for free; all others can purchase for $10.) There will be more content from the AI Symposium in APPLIED in a few weeks! Finally, check out our Instagram and Facebook pages for behind-the-scenes photos of this inaugural event.
READ THE WRAP-UP
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SLAS
If the wrap-up and webinar leave you craving more AI symposium-related content, check out two additional interviews from our friends at Select Science. First, catch up with Ville Lehtonen, founder and CEO of LabMinds, as he discusses current developments in AI within drug discovery, his predictions for future development, what challenges lie ahead and how collaboration is the key to innovation. Then, watch Dr. Oren Kraus demonstrate the use of AI in image-based phenotypic screening in a video from June's SLAS Europe 2019 Conference and Exhibition.
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WATCH THE INTERVIEW
SLAS
Kicking off this year's SLAS 2019 Americas Sample Management Symposium (Boston, MA, USA), is Juan Alvarez, Ph.D., (Merck and Co.) who will be giving attendees an inside look at the how the use of ML in drug discovery has created next-level breakthroughs. Alvarez will cover current advances in predictive models and process development, as well as some of the pitfalls that go along with overuse and misapplication. Learn more about Alvarez, his presentation and the rest of the 2019 program.
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SLAS
SLAS Journal Special Issues Call for Papers
Hit Discovery Methodology
Proposals due: November 1
Early Drug Discovery Approaches with More Physiologically Relevant Targets
Proposals due: November 1
AI in Process Automation
Proposals due: December 31
For more information about SLAS Discovery and SLAS Technology advertising and sponsorship opportunities, contact Holly Dietz at SAGE Publications.
Upcoming Events
Come see SLAS at these important events:
UNC Eshelman Ignite Innovation Symposium (ticketed event)
October 11, 2019
Chapel Hill, NC, USA
LRIG Philadelphia Fall Exhibition 2019
October 17, 2019
4:00 – 8:00 p.m. EDT
DoubleTree by Hilton Philadelphia-Valley Forge, King of Prussia, PA, USA
UMass Amherst Life Sciences and Biotechnology Internship & Career Fair
October 29, 2019
Amherst, MA, USA
labtech China Congress 2019
November 6-8, 2019
Kerry Hotel Pudong
Shanghai, China
SLAS is sponsoring the event's Live Lab!
SLAS 2019 Advanced 3D Human Models and High-Content Analysis Symposium
October 21 – 22
London, UK
Sponsorship Opportunities Available: Contact Genco Turkmen
SLAS 2019 Americas Sample Management Symposium
November 20 – 21
Boston, MA, USA
Sponsorship Opportunities Available: Contact Karen Layser
SLAS2020 International Conference and Exhibition
January 25 – 29, 2020
San Diego, CA, USA
Call for Poster Abstracts Open
View SLAS2020 Sponsorship Opportunities
View Exhibitor Opportunities
COMPLETE LIST OF SLAS CONFERENCES AND SYMPOSIA
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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Journal of the American Chemical Society
Reported here is a molecular construct (K1) designed to overcome hurdles associated with delivering active drugs to heterogeneous tumor environments. Construct K1 relies on two cancer environment triggers (GSH and H2O2) to induce prodrug activation. It releases an active drug form (SN-38) under conditions of both oxidative and reductive stress in vitro. Specific uptake of K1 in COX-2 positive aggressive colon cancer cells (SW620 and LoVo) was seen, along with enhanced anticancer activity compared with the control agent SN-38.
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Chemical & Engineering News
Sugar molecules called glycans, which attach to proteins and lipids to regulate how they fold and function, also bind to RNA, reports a study posted to bioRxiv. The finding overturns biochemical dogma and hints at new roles for both RNA and glycans — if the results stand up to peer review and replication by other groups.
"If it's verified I think it would open up a new avenue of research into the structure and function of such modifications of RNA," says Richard Cummins, a glycobiologist at Harvard University.
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Science Magazine
The Human Genome Project's completion in 2003 brought hope that geneticists would soon uncover the genes behind scourges such as heart disease and Alzheimer's. But soon came a reality check: Most common diseases have been tied not to a few genes, but scores or even hundreds, each raising a person's risk of disease by a tiny amount.
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Phys.org
Scientists in Australia have developed a world-first compound that can keep cells alive and functioning in a perfectly healthy state when they otherwise would have died. The ability to swiftly intervene and prevent cell death, or apoptosis, could be game-changing for medical emergencies and procedures, such as minimising cellular damage after heart attacks, or preserving organs for transplants.
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The Scientist
"Upload DNA data and know more about yourself," promises Genomelink, anywhere from fitness-related attributes, such as longevity, pulmonary function and job-related exhaustion, to intelligence-associated characteristics, including mathematical ability, hippocampal volume and educational attainment. Just send over your data obtained from DNA testing companies such as 23andMe, Ancestry or My Heritage and the California-based company will send back insight into more than 125 traits.
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Genetic Engineering & Biotechnology News
A radically redesigned viral vector may improve the delivery of therapeutic genes to patients with sickle-cell disease. According to tests in animal models, the new vector is up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than conventional vectors, and it has a carrying capacity that is up to six times higher.
The conventional vectors that have been used to deliver gene therapies for sickle-cell disease have a reverse structural orientation.
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Science Daily
Zeolites are a class of natural or manufactured minerals with a sponge-like structure, riddled with tiny pores that make them useful as catalysts or ultrafine filters. But of the millions of zeolite compositions that are theoretically possible, so far only about 248 have ever been discovered or made. Now, research from MIT helps explain why only this small subset has been found, and could help scientists find or produce more zeolites with desired properties.
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Lab Manager
Investigation of biological mechanisms in urothelial tissue — one of the three types of tissue that make up the urinary system — has always been very limited due to the lack of technologies that allow working with stable and long-term populations of the cells that compose it. As a consequence, the mechanisms underlying diseases such as bladder cancer — 90 percent of these tumors originate in urothelial cells — or cystitis remain poorly understood.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Laboratory Automation Engineer
Sera Prognostics
US – UT – Salt Lake City
CLINICAL LAB SCIENTIST- Bloodbank- PRN
Saint Francis Hospital – Memphis
US – TN – Memphis
Postdoctoral Research Associate
Princeton University
US – NJ – Princeton
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