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SLAS
SLAS Discovery is seeking manuscript proposals (abstracts) on topics related to Advances in Cellular Target Engagement and Target Deconvolution for publication in a 2020 special issue. Guest Editors Martin Main, Ph.D., (Medicines Discovery Catapult, Alderley Edge, UK) and Andrew Zhang, Ph.D., (AstraZeneca, Boston, MA, USA) invite manuscript proposals (abstracts) related to all methods for monitoring compound-target engagement in cells and for deconvoluting the molecular target of biologically active compounds. Manuscript proposals (abstracts) are due March 1, 2019. Invited submissions will be due July 1, 2019. (SLAS Discovery is formerly known as the Journal of Biomolecular Screening.)
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SLAS
What did the SLAS2018 Ignite Collaboration Presentations do for Santosh Paidi, a graduate research assistant at Johns Hopkins University (Baltimore, MD, USA)? "SLAS Ignite was a great opportunity, especially because of the location within the SLAS2018 exhibition," says Paidi, who shared, "Label-Free Raman Spectroscopy for Rapid Identification of Biologics," in the inaugural SLAS Ignite Academic Theater. "After the presentation, the questions were insightful, and people wanted to meet to discuss the research. Some researchers contacted my advisor after the conference to discuss potential avenues for collaboration," says Paidi. "Presenting your work at the SLAS International Conference and Exhibition is important. It gives you an opportunity to evaluate how your academic projects can meet actual needs in health care or industry." The deadline for abstracts is Wednesday, Oct. 31.
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SLAS
Three scientists who recently received the 2018 Nobel Prize in Chemistry have interesting links to the SLAS Journals. Frances H. Arnold, Ph.D., (California Institute of Technology, Pasadena, CA, USA), received recognition for her work on directing the evolution of enzymes. Arnold's research into colorimetric assays developed to support the directed evolution of bacterial dioxygenases appears in the Journal of Biomolecular Screening (now publishing as SLAS Discovery), and is one of five articles she published with SLAS. The chemistry prize also honored British scientist Sir Gregory P. Winter, Ph.D., (University of Cambridge, UK) and George P. Smith, Ph.D., (University of Missouri, Columbia, MO, USA), for their work on phage display of peptides and antibodies. Research based on their phage display technology was featured in a 2007 Journal of Biomolecular Screening article to enable a screen for tumor-binding peptides.
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SLAS
Are you ready to present your work and gain exposure for your research? John Hickey, one of three winners of the 2018 SLAS Student Poster Competition, explains how the poster prepping process helped him streamline his research and clearly present it to others. "The competition helped me scrutinize the layout and content of my poster more closely," says Hickey in an SLAS Electronic Laboratory Neighborhood e-zine article. "In the end, the process taught me more about designing an effective scientific poster, and I ended up with a more polished product." Hickey, a Ph.D. candidate in biomedical engineering at The Johns Hopkins University School of Medicine (Baltimore, MD, USA), encourages other students to participate at SLAS2019. For more details on constructing a killer poster, read SLAS Scientific Director Mike Tarselli's latest column. Submit your work to be considered for the SLAS Student Poster Competition by Monday, Oct. 29.
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SLAS
SLAS Technology guest editors seek manuscript proposals (abstracts) for two new special issues to be published in 2019:
- Guest Editors S.J. Claire Hur, Ph.D., (Johns Hopkins University, Baltimore, MD, USA) and Deok-Ho Kim, Ph.D., (University of Washington, Seattle, WA, USA) invite manuscript proposals (abstracts) on Engineering Innovations for Fundamental Biology and Translational Medicine. Manuscript proposals (abstracts) are due Friday, Oct. 26. Invited submissions will be due Jan. 1, 2019.
- Guest Editors Hideaki Tsutsui, Ph.D., (University of California, Riverside, CA, USA) and Peter B. Lillehoj, Ph.D., (Michigan State University, East Lansing, MI, USA) invite the submission of abstracts on Flexible Analytical Devices for Point-of-Care Testing. Manuscript proposals (abstracts) are due March 1, 2019. Invited submissions will be due July 1, 2019.
(SLAS Technology is formerly known as the Journal of Laboratory Automation.)
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SLAS
Expand your academic horizon! The SLAS Grants Program is now accepting applications for 2019 awards. For Kelci Schilly, the SLAS Visiting Graduate Researcher Program funds her exploration of paper-based microfluidics and peptide labeling for mass spectrometric detection. "I would recommend that graduate students apply for the program because it gives you the opportunity to travel to another lab, meet new researchers and learn from their work," says Schilly, who is working for a portion of a semester in the lab of SLAS President Sabeth Verpoorte, Ph.D., (University of Groningen, The Netherlands). SLAS Graduate Education Fellowship Grant recipient Santosh Paidi is using the funding to support development of his SERS diagnostic assay concept in the lab of Ishan Barman, Ph.D., (Johns Hopkins University, Baltimore, MD, USA). "This grant opens doors to challenging questions, one of which is how to quantitatively access the DNA of circulating tumor cells," Paidi says. The deadline for both grant applications is Dec. 10, 2018.
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SLAS
2018 SLAS Advanced 3D Human Models and High-Content Analysis Conference
Oct. 17-19, 2018
Leiden, Netherlands
Join SLAS next week to discover a new landscape where its routine to build, measure and screen human tissue models. Learn how new technologies enable meaningful results in human disease models. READ MORE
2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic
November 13-14, 2018
Boston, MA
Tuesday, Oct. 16: Secure discounted hotel rates at the Omni Parker House (rooms are going fast)
SLAS Journal Special Issue Calls for Papers
Engineering Innovations for Fundamental Biology and Translational Medicine
Friday, Oct. 26: Proposals due
Jan. 1, 2019: Invited submissions due
Membrane Proteins: New Approaches to Probes, Technologies and Drug Design
Thursday, Nov. 1: Proposals due
March 1, 2019: Invited submissions due
Flexible Analytical Devices for Point-of-Care Testing
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
Advances in Cellular Target Engagement and Target Deconvolution
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
Carbohydrate Structure Analysis: Methods and Applications
May 1, 2019: Proposals due
Aug. 10, 2019: Invited submissions due
SLAS2019 International Conference and Exhibition
Feb. 2-6, 2019
Washington, DC Tuesday, Oct. 16: Innovation AveNEW application deadline
Monday, Oct. 29: SLAS Student Poster Competition abstracts due
Wednesday, Oct. 31: Member-only registration discount deadline
Wednesday, Oct. 31: SLAS Ignite Collaboration Presentation abstracts due Thursday, Jan. 3, 2019: Deadline for conference hotels discount (reservations made after this date will receive the group rate based only on individual hotel availability)
Monday, Jan. 21, 2019: Final poster submission deadline
Sponsorship opportunities available!
LRIG Fall Meetings
Learn more about the SLAS and its journals and enter to win a full conference registration for SLAS2019 at these upcoming LRIG chapter meetings (attendance is free, but preregistration is encouraged):
Thursday, Oct. 18: LRIG San Diego Chapter Exhibition and Rapid Fire
Tuesday, Oct. 30: LRIG Philadelphia Chapter Fall Vendor Exhibition
Save the Date: 2019 SLAS Europe Conference and Exhibition
June 26-28, 2019
Barcelona, Spain
Exhibit and sponsorship opportunities available!
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Journal of the American Chemical Society
A thermally activated delayed fluorescence (TADF) tetrametallic Cu(I) metallacycle A behaves as a conformationally adaptive preorganized precursor to afford, through straightforward and rational coordination-driven supramolecular processes, a variety of room-temperature solid-state luminescent polymetallic assemblies. Reacting various cyano-based building blocks with A, a homometallic Cu(I) 1D-helical coordination polymer C and Cu8M discrete circular heterobimetallic assemblies DM (M = Ni, Pd, Pt) are obtained.
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Science Daily
Scientists at the University of Toronto have found a way to select the outcome of chemical reaction by employing an elusive and long-sought factor known as the "impact parameter."
The team of chemists, led by Nobel Prize-winning researcher John Polanyi, have found a means to select the impact parameter or miss-distance by which a reagent molecule misses a target molecule, thereby altering the products of chemical reaction.
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The Scientist
Two studies published in Nature Medicine report success using modified CRISPR-Cas9 gene editing to prevent or cure two inherited diseases in mice. In one study, researchers corrected the gene mutation that causes phenylketonuria (PKU) in the livers of adult mice; in the other, editing short-circuited a condition similar to the human disease HT1 in the livers of fetal mice.
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Genetic Engineering & Biotechnology News
The cancer immunotherapy toolbox may one day make room for a new tool, the DNA-encoded monoclonal antibody (DMAb). Like conventional monoclonal antibodies, DMAbs bind to cancer checkpoint molecules, thereby releasing the brakes on immune cell activity. Unlike conventional monoclonal antibodies, DMAbs are expressed in vivo rather than being painstakingly manufactured, stored, transported, and finally administered. Moreover, in mice, DMAbs are expressed persistently, suggesting that DMAbs could spare human cancer patients the trouble of repeat dosing.
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Phys.org
Microfluidic devices can take standard medical lab procedures and condenses each down to a microchip that can balance on top of a water bottle lid. A team from Michigan Technological University, studying chemical engineering, electrical engineering and materials science, streamline the design of microfluidic devices to be see-through to observe their inner workings. Using hair-thin tunnels and equally tiny electrodes, these devices funnel fluids through an electric current to sort cells, find diseases and run diagnostic tests.
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Chemical & Engineering News
With surfaces reflecting the world above while obscuring mysteries below, lakes have long beguiled scientists and poets alike. Alexander von Humboldt went to Lake Atitlán in Guatemala; Charles Darwin, to Tagua-Tagua in Chile. Henry David Thoreau lived on Walden Pond (a lake) in Massachusetts, Lord Byron entertained on Lake Geneva in Switzerland, and William Wordsworth roamed England's Lake District.
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Laboratory Equipment
For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth.
Published in Nature Medicine, research from the Perelman School of Medicine at the University of Pennsylvania and the Children's Hospital of Philadelphia (CHOP) and offers proof-of-concept for prenatal use of a sophisticated, low-toxicity tool that efficiently edits DNA building blocks in disease-causing genes.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Senior Research Associate, Lead Discovery
Epizyme, Inc.
US – US – Cambridge
Assistant Clinical Investigators, NIAID Transition Program in Clinical Research
National Institute of Allergy and Infectious Diseases / National Institutes of Health
US – MD – Bethesda
Postdoctoral Position - Locus Coeruleus Activity in Behaving Rat
Rutgers Brain Health Institute
US – NJ – Piscataway
Search Jobs at SLAS Career Connections
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