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SLAS journal showcases technological breakthroughs
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The October issue of JALA features the JALA Ten — those leading discoveries that are helping to shape the next generation of transformative technologies for biology and medicine.
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Interrogating Chemical Space virtual course begins Oct. 25
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Chris Lipinski, Dan Erlanson, Mike Hann and Dan Wyss explore lead discovery from multiple angles during "Interrogating Chemical Space — Rules, Filters, Fragment-Based Screening
and Beyond." Experience this four-module course live or on-demand. And, be sure to read the ELN feature on this topic.
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JALA Editorial Board member en route to White House
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Congratulations to Ali Khademhosseini, Ph.D., of Harvard Medical School in Cambridge, Mass., who will be meeting with President Obama to receive a 2011 Presidential Early Career Award
for Scientists and Engineers.
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JBS goes mobile
SLAS Share
Be sure to visit JBS on your smartphone to experience the new mobile-optimized format
featuring full-text content of the current issue, archives and OnlineFirst articles, as well as simplified search, authentication and sharing tools.
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Keys to success via laboratory technology
SLAS Share
"The path from scientific hypothesis to final conclusion is, regardless of technology, still rooted in asking and answering good scientific questions." Read more from SLAS Director of Education Steve Hamilton on pages 57-59 of the Autumn issue of Innovation Into Success, a publication of the United Kingdom Science Park Association.
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SLAS2012 registration discounts through Oct. 31
SLAS Share
SLAS members registering by Oct. 31 save up to $300 to attend the First Annual SLAS Conference and Exhibition, Feb. 4-8, San Diego.
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SRU Biosystems has introduced the first and only high resolution, optical, label-free plate reader. Capable of measuring functional responses in individual cells, the SCANNER represents a new paradigm in drug discovery enabling the use of primary cells earlier in drug discovery process. Contact us to learn more.
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Ultra Low Attachment Surface plates feature a covalently bound hydrogel layer that effectively inhibits cellular attachment, minimizes protein absorption, enzyme activation, and cellular activation. Corning® introduces 384 well black clear bottom Ultra Low Attachment Surface plates for HTS applications of tumor spheroid and stem cell embryoid body
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Electrochemical nanosensor for real-time direct imaging of nitric oxide in living brain
Analytical Chemistry Share
As gaseous nitric oxide, a critical and multifaceted biomarker, diffuses easily once released, identifying the precise sources of NO release is a challenge. This study developed a new
technique for real-time in vivo direct NO imaging by coupling an amperometric NO nanosensor with scanning electrochemical microscopy.
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Total synthesis of (—)-N-methylwelwitindolinone C isothiocyanate
Journal of the American Chemical Society Share
We report the first total synthesis of (−)-N-methylwelwitindolinone C isothiocyanate. Our route features a number of key transformations, including an indolyne cyclization to assemble the [4.3.1]-bicyclic scaffold, as well as a late-stage intramolecular nitrene insertion to functionalize the C11 bridgehead carbon en route to the natural
product.
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Nature Middle East is a FREE resource for scientists and clinicians to
connect, research, network and exchange information and ideas. Sign up to the latest research coming out of the Arab world and become part of the of Nature Middle East community.
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Hepatocyte entry leads to degradation of autoreactive CD8 T cells
National Academy of Sciences Share
Although most self-reactive T cells are eliminated in the thymus, mechanisms to inactivate or control T cells specific for extrathymic antigens are required and exist in the periphery. By investigating the site in which autoreactive T cells are tolerized, we identify a unique mechanism of peripheral deletion in which naïve autoreactive CD8 T cells are rapidly eliminated in the liver after intrahepatic
activation.
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Mass spectrometry propels the field of lipidomics
Chemical & Engineering News Share
In the "omics" world, lipids have long been in the shadows, while nucleic acids and proteins hogged the limelight. But now, this broad-ranging
class of biomolecules is stepping into the spotlight as well. And mass spectrometry is the tool that is making it possible.
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Perspective article examines conductivity at the LaAlO3 and SrTiO3 (001) interface
Phys Org Share
Complex oxides have the potential to inject new functionalities into technologies that require semiconductors. The correlated behavior of itinerant electrons in these materials sets complex oxides apart from traditional semiconductors such as Si and GaAs. Potential applications abound, but the fundamental properties of these materials,
particularly when combined to make interfaces, must be understood.
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Ancient gene found to control potent antibody response to retroviruses
eBio News Share
A researcher at MIT's Koch Institute for Integrative Cancer research has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses.
Edward Browne shows that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction.
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Bacteria in your belly button
Live Science Share
Unknown and mysterious species of microbe lurk in our belly buttons, the Bellybutton Biodiversity project, is finding. Preliminary results from the project, based at North Carolina State University, show hundreds of new or little-known types of bacteria living in navels. Some of these miniscule creatures can grow into fuzzy colonies on Petri dishes.
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Searching for life in all the right places
Popular Science Share
Curious about just how astrobiologists plan to make good on their goal to find life in space in the next 20 years? Popular Science has compiled some of the coolest upcoming search-for-life projects they could find — check out a feature on the subject, and browse a photo gallery for a guide to some of the most impressive efforts directed at finding extraterrestrial life.
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Thermo Scientific Orbitor KingFisher Flex Extraction Workstation allows users to extract more nucleic acids/proteins in less time. The small, easy-to-use solution provides unattended walk-away time, better control of processes and greater sample consistency combined with an audit trails of all operations performed (time-stamped, stored
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The comPOUND system comprises a high-density sample storage unit and an additional suite of specialized delivery and
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Venenum BioDesign specializes in HTS of 5.5 million compounds including new libraries for protein-protein interactions.
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The all-new, four-part SLAS virtual course – Interrogating Chemical Space
– kicks off Oct. 25. Register today!
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JALA is a multi-disciplinary international forum devoted to the advancement of technology in the laboratory.
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