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  Mobile version   RSS   Subscribe   Unsubscribe   Archive   Media Kit Oct. 17, 2012

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SLAS2013 program preview now at SLAS2013.org!
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Take a trip to the SLAS2013 website and breeze through the recently posted, 30-page preliminary program booklet highlighting the robust offerings that await participants Jan. 12-16 in Orlando, Fla. Explore links to additional conference information in the SLAS2013 Event Scheduler (full detail on sessions and speakers), interactive exhibition floorplan and SLAS Electronic Laboratory Neighborhood features on related content. SLAS members: register by Oct. 31 for deepest discounts! More

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Next-Gen Sequencing: Making a Difference in Patient Care
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"The members of our department realized several years ago that it was going to be impossible to keep up with the rapid pace of molecular oncology discovery using the old paradigm of single-gene testing," says Eric J. Duncavage, M.D. Duncavage and his colleagues at Washington University School of Medicine in St. Louis are among a handful of research teams who have developed next generation DNA sequencing panels for cancer to help oncologists improve patient care. Read more about this SLAS2013 speaker's work in SLAS Electronic Laboratory Neighborhood. More

JBS special issue coincides with Nobel Prize announcement
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"How timely the JBS stem cell special issue is in light of the Nobel Prize awarded last week," says Marcie Glicksman who served with Laura Pajak and Kelvin Lam as guest editor for the just published issue. Sir John B. Gurdon and Shinya Yamanaka were named Nobel Prize in Physiology or Medicine winners Oct. 8 "for the discovery that mature cells can be reprogrammed to become pluripotent." More



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Ambassador visits SLAS booth at MipTec
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The United States Ambassador to Switzerland Donald S. Beyer Jr. (right) visited MipTec 2012 and made a stop at the SLAS booth. Longtime SLAS member Al Kolb spent a few minutes with the ambassador talking about the international scope of SLAS and discussing the state of drug discovery worldwide. MipTec, held annually in collaboration with SLAS, provides a platform for networking, scientific exchange and technological innovation to academic and industrial scientists. Photo by Sascha Grimmer. More


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Lefkowitz awarded Nobel Prize in Chemistry
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Robert J. Lefkowitz, who along with Brian K. Kobilka was awarded the 2012 Nobel Prize in Chemistry Oct. 10 for studies of G-protein-coupled receptors, was a keynote speaker at SBS 2011 and an SBS Achievement Award winner. How have the contributions of these two 2012 Nobel Prize awardees, as well as Sir John B. Gurdon and Shinya Yamanaka, impacted your work? Share your story in the SLAS LinkedIn community. More

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Researchers use voltammetry to probe the brain's chemistry
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Our brains are constantly awash in chemicals that serve as messengers, transporting signals from one neuron to another. It's a really nifty system, although scientists still aren't clear on how, exactly, those chemical messages end up being converted into behaviors like kicking a ball or doing really complicated mathematical computations. More


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Measuring the electric charge and zeta potential of nanometer-sized objects using pyramidal-shaped nanopores
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Nanometer-scale pores are capable of detecting the size and concentration of nanometer-sized analytes at low concentrations upon analyzing their translocation through the pore, in small volumes and over a short time without labeling. Here, we present a simple, widely applicable, robust, and precise method to measure the zeta-potential of different nano-objects using nanopores. More

RNA gets excited
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have long suspected that many RNA molecules have short-lived, low-abundance excited states, but those states have been difficult to characterize. Now, Hashim M. Al-Hashimi and coworkers at the University of Michigan, Ann Arbor, have developed a method to trap and observe these RNA excited states. The excited states typically last for microseconds and account for less than 5 percent of the population of a particular RNA molecule. More



Claim of first human stem cell trial unravels
NewScientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
It has been a crazy week for stem cell research. After the high of a Nobel prize for Japan's Shinya Yamanaka, the pioneer of cellular reprogramming, events took an alarming and surreal turn when a little-known compatriot — Hisashi Moriguchi — claimed to have already run a clinical trial in which similarly reprogrammed cells were injected into people. But Moriguchi's claims quickly unravelled. More

Freezing electrons in flight: Physicists catch electrons getting knocked out of atoms
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Using the world's fastest laser pulses, which can freeze the ultrafast motion of electrons and atoms, University of Arizona physicists have caught the action of molecules breaking apart and electrons getting knocked out of atoms. Their research helps us better understand molecular processes and ultimately be able to control them in many possible applications. More


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Funding opportunity from Neurofibromatosis Therapeutic Acceleration Program
Neurofibromatosis Therapeutic Acceleration Program     Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Neurofibromatosis Therapeutic Acceleration Program seeks applications by noon EST Nov. 9 to support the development of novel cell culture model systems for neurofibromatosis type 1 (NF1)-associated plexiform neurofibromas. Successful proposals will focus on the development of innovative cellular model systems that address the challenges typically encountered in developing disease relevant cellular models including early senescence of nonmalignant cells, limited genotypic, phenotypic and functional characterization (at the DNA, RNA, protein, and functional levels), disease relevance, stability and reproducibility, failure to represent the complexity of human tumors in their multi-cell type composition, interactions with the microenvironment and the biological diversity. More

White paper explores effective protein purification
Rainin Instrument     Share    Share on FacebookTwitterShare on LinkedinE-mail article
Rainin Instrument published "High Throughput FPLC with Packed Resin Tip Technology." The paper helps shed light on how novel resin tips promote easier, faster and more cost-effective protein and antibody purification than can be achieved using traditional gravity/spin columns. Using conventional spin columns, protein purification requires a relatively large amount of resin for acceptable performance. However, experiments detailed in the white paper indicate that the higher resin volumes required in spin columns are not the key to optimizing workflow. More

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Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Porphyrin–phospholipid conjugates were used to create photonic microbubbles having a porphyrin shell, and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin–lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. More

Stem cells from muscle tissue may hold key to cell therapies for neurodegenerative diseases
eBioNews    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at Wake Forest Baptist Medical Center have taken the first steps to create neural-like stem cells from muscle tissue in animals. Details of the work are published in two complementary studies published in the September online issues of the journals Experimental Cell Research and Stem Cell Research. In an earlier study, the same team isolated neural precursor cells derived from skeletal muscle of adult transgenic mice. More

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Human cadaver brains may provide new stem cells
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Death will come for us all one day, but life will not fade from our bodies all at once. After our lungs stop breathing, our hearts stop beating, our minds stop racing, our bodies cool, and long after our vital signs cease, little pockets of cells can live for days, even weeks. Now scientists have harvested such cells from the scalps and brain linings of human corpses and reprogrammed them into stem cells. More

Obesity promotes tumor growth regardless of diet
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers may have discovered a new explanation as to why obese patients with cancer often have a poorer prognosis compared with those who are lean. "Studies of the population have clearly established that there is a link between obesity and cancer incidence," said Mikhail Kolonin, Ph.D., associate professor at the Institute of Molecular Medicine at The University of Texas Health Science Center at Houston. More


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Career


QC Microbiology Scientist/Sr. Scientist
Genentech
USA – CA – South San Francisco

HTP DNA Sequencing and Genotyping Scientist
St. Jude Children's Research Hospital
USA – TN – Memphis

Assistant Professor
Colorado School of Mines
USA – CO – Golden

More jobs at SLAS Career Connections


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