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SLAS2018 Student Poster Competition Deadline is Oct. 30
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SLAS rewards notable achievements by undergraduate, graduate and post-doctoral students who participate in the annual SLAS Student Poster Competition. Three next generation scientists presenting innovative research at SLAS2018 will earn a $500 cash award, an invitation to submit their work for fast-track publication in one of SLAS's official scientific journals and a one-on-one interview with The Lab Man.
Pictured here are SLAS2017 Student Poster Competition winners Bilal Zulfiqar (Griffith University, Australia), Alice Bong (University of Queensland, Australia) and Sudip Mondal (The University of Texas at Austin) with The Lab Man.
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Isolation of Mitochondrial DNA from Single, Short Hairs without Roots Using Pressure Cycling Technology
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A new manuscript from the United States Federal Bureau of Investigation in SLAS Technology details why standard nuclear DNA analysis of hairs is not always possible and outlines an alternative.
"Mitochondria (mt) provide another source of genetic material; however, manual isolation is laborious. In a proof-of-concept study, we assessed pressure cycling technology (PCT); an automated approach that subjects samples to varying cycles of high and low pressure) for extracting mtDNA from single, short hairs without roots. Using three microscopically similar donors, we determined the ideal PCT conditions and compared those yields to those obtained using the traditional manual micro-tissue grinder method. Higher yields were recovered from grinder extracts, but yields from PCT extracts exceeded the requirements for forensic analysis, with the DNA quality confirmed through sequencing."
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SLAS2018 Assay Guidance Workshop for High-Throughput Screening and Lead Discovery
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An experienced faculty helps researchers understand the "tribal knowledge" built over decades to help facilitate reproducible assays that can identify the most promising compounds for development of molecular probes or clinical candidates for drug discovery and development. Academic, industrial and government laboratory scientists who are planning or beginning to develop test methods for high- or low-throughput screening that are amenable to automation using appropriate statistical and operational concepts will find this workshop valuable, as will early career researchers and experienced investigators who wish to learn about the latest assay concepts for high-throughput screening and lead optimization.
This Saturday, Feb. 3, workshop requires an additional fee. Register now. Read about the SLAS2017 workshop in the SLAS Electronic Laboratory Neighborhood e-zine.
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Have You Made Your SLAS2018 Hotel Reservations Yet?
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SLAS has negotiated discounted rates for SLAS2018 participants with the Marriott Marquis San Diego Marina and Hilton San Diego Bayfront. Both hotels are conveniently adjacent to the San Diego Convention Center. The Marriott Marquis is the SLAS2018 headquarters hotel, closest to the space in the Convention Center where SLAS2018 sessions will be held.
The deadline for booking hotel accommodations at the negotiated SLAS2018 rates is Jan. 4, 2018. Discounted rates are not guaranteed for reservations made after Jan. 4.
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Advance Your Professional Success: Publish in SLAS Journals
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SLAS Discovery and SLAS Technology welcome manuscript submissions on an ongoing basis from SLAS members and non-members. Backed by the world-class education standards of SLAS, submissions are rigorously peer-reviewed and there are no article processing charges (APCs). Open access options are available.
SLAS journals address the full spectrum of issues that are mission-critical to life sciences professionals, enabling research teams to gain scientific insights; increase productivity; elevate data quality; reduce process cycle times; and enable research and development that otherwise would be impossible.
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On the Road with the SLAS CEO
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Two more entries have been added to SLAS CEO Vicki Loise's blog, shining a spotlight on SLAS events, members and activities from around the globe. The first details a trip to Madrid for the SLAS High-Content Screening Conference and the second SLAS's participation in ELRIG Drug Discovery 2017.
At both events, "there was also quite a bit of buzz about the 2018 SLAS Europe Conference and Exhibition," Loise says. "We had the chance to speak with many exhibitors and again the feedback was this brand new SLAS event is not to be missed! If you haven't budgeted to attend SLAS Europe yet, do so now. It will be a great gathering of the SLAS Europe community."
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SLAS2018 Deadline Reminders
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SLAS looks forward to your participation Feb. 3-7 in San Diego!
Browse www.SLAS2018.org and the SLAS2018 Event Scheduler for the latest information about scientific podium presentations, exhibitors, Short Courses, and the most up-to-date schedule of events.
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Neutrons Observe Vitamin B6-Dependent Enzyme Activity Useful for Drug Development
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Scientists at the Department of Energy's Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria and diabetes.
Specifically, the team used neutron crystallography to study the location of hydrogen atoms in aspartate aminotransferase, or AAT, an enzyme vital to the metabolism of certain amino acids.
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Modified CRISPR Screen Identifies Genes that Protect against Disease
Genetic Engineering & Biotechnology News Share
Scientists at the Massachusetts Institute of Technology have developed a modified form of CRISPR/Cas9 gene editing that can effectively screen cells for genes that protect against different diseases. Led by Timothy Lu, M.D., Ph.D., associate professor of electrical engineering and computer science, and of biological engineering, the MIT team used the technique in a yeast model of Parkinson's disease to identify genes that protected against α-synuclein (αSyn) toxicity.
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'Roller-Wheel'-Type Pt-Containing Small Molecules and the Impact of 'Rollers' on Material Crystallinity, Electronic Properties, and Solar Cell Performance
Journal of the American Chemical Society Share
We report the synthesis, characterization, and detailed comparison of a series of novel Pt-bisacetylide containing conjugated small molecules possessing an unconventional "roller-wheel" shaped structure that is distinctly different from the "dumbbell" designs in traditional Pt-bisacetylide containing conjugated polymers and small molecules.
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New Technique Scours the Genome for Genes That Combat Disease
Bioscience Technology Share
Using a modified version of the CRISPR genome-editing system, MIT researchers have developed a new way to screen for genes that protect against specific diseases.
CRISPR is normally used to edit or delete genes from living cells. However, the MIT team adapted it to randomly turn on or off distinct gene sets across large populations of cells, allowing the researchers to identify genes that protect cells from a protein associated with Parkinson's disease.
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Scientists Use Machine Learning to Reveal Chemical Reactions in Real Time
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A joint Stony Brook-BNL research team has found a way to capture the details of chemistry's elaborate choreography as it happens. Led by Anatoly Frenkel, a professor in Stony Brook University's Materials Science and Chemical Engineering Department who has a joint appointment with Brookhaven National Laboratory's Chemistry Division, the team relied on computers that have learned to recognize the steps in a complex dance of atoms involved in chemical reactions.
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Bryostatin Advances: A Shorter Synthesis and an HIV Takedown
Chemical & Engineering News Share
The marine natural product bryostatin 1 has shown promise as a treatment for cancer, Alzheimer's disease and HIV. But neither the compound nor its analogs have become approved drugs. One of the problems that has dogged bryostatin 1 is its scarce supply. Now, chemists at Stanford University led by Paul A. Wender have developed a shortened synthesis of bryostatin 1 capable of supplying sufficient amounts of the compound for clinical trials.
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Zika Vaccine Shows Promise in Early Clinical Trial
The Scientist Share
A DNA vaccine against Zika virus has shown promising results in an early human trial. The results appeared in the New England Journal of Medicine.
"Zika virus continues to be a threat to people living in the Americas and the Caribbean," lead author Pablo Tebas, a professor of infectious diseases at the University of Pennsylvania, says in a release. "With these new results, we are one step closer to hopefully finding a way to prevent infection, which can cause serious birth defects and developmental delays in babies born to women who are infected with Zika."
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Converting Carbon Dioxide to Carbon Monoxide Using Water, Electricity
Science Daily Share
Researchers at the University of Illinois at Chicago and the Joint Center for Artificial Photosynthesis have determined how electrocatalysts can convert carbon dioxide to carbon monoxide using water and electricity. The discovery can lead to the development of efficient electrocatalysts for large scale production of synthesis gas — a mixture of carbon monoxide and hydrogen.
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