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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit October 19, 2016

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Oct. 25 SLAS Webinar: Biospecimen Commons — A Tool for Encouraging Openness and Transparency in Biospecimen Sample Collection
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Joseph Miceli, Ph.D., heads the development of Biospecimen Commons, an open access database developed between Arizona State University and Global Biological Standards Institute. The goal of Biospecimen Commons is to increase reproducibility and transparency in preclinical research by making protocols used in specimen collection publicly available.

On Oct. 25 at 11:30 a.m. EDT, Miceli describes the problem and explores solutions in this SLAS Webinar free to dues-paid SLAS members. Not yet an SLAS member? Join today and receive full benefits through end of 2017.
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SLAS2017 Student Poster Competition Deadline is Oct. 31
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SLAS awards notable achievements of undergraduate, graduate and post-doctoral students participating in the annual SLAS Student Poster Competition. The top three next generation scientists presenting their innovative research at SLAS2017 are selected to win a $500 cash award, an invitation to submit their work for fast-track publication in one of SLAS's official scientific journals and a one-on-one interview with The Lab Man.

Pictured here are SLAS2016 Student Poster Competition winners Joohun Kang, Carrie Lovitt and Masturah Bte Mohd Abdul Rashid.
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SLAS ELN Reports: Undruggable or Just Undrugged? Exploring Alternative Targets
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The world of drug discovery continues to evolve with changes in the availability of analytical tools and reagents and new strategies leveraged to pursue molecular targets previously considered to be undruggable. This is especially true in oncology where there are large numbers of challenging molecular targets identified but not yet exploited for pharmacological intervention.

So says SLAS2017 Session Chair John S. Lazo, Ph.D., professor at the University of Virginia School of Medicine and director of the Fiske Drug Discovery Laboratory. Lazo is helping to debunk the concept that certain molecular targets are undruggable. Read more in the SLAS Electronic Laboratory Neighborhood e-zine feature article.
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Register for SLAS2017 by Oct. 31 and Save
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Deeply discounted SLAS2017 early bird registration rates, exclusively for SLAS dues-paying members, are available through Oct. 31. Renew your member dues or join SLAS today and take advantage of these special rates, plus enjoy year-round member benefits through the end of 2017. Other special rates and discounts are available for students and those from the same organization who register at the same time in groups of five or more.

Be sure to access the SLAS2017 Event Scheduler for the latest information about scientific podium presentations, including abstracts and presenter bios; exhibiting companies and descriptions; Short Course information and abstracts; and the latest schedule of events.
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$100K SLAS Graduate Education Fellowship Grant Applications Due Nov. 16
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The SLAS Graduate Education Fellowship Grant Program facilitates educational opportunities for outstanding students pursuing graduate degrees related to quantitative biosciences and/or life sciences research. SLAS awards up to $50,000 per year, for a maximum of two years, to qualified educational institutions on behalf of deserving students enrolled in a graduate program at that institution. A student’s primary research investigator or mentor needs to apply on behalf of the student.

Erik M. Werner (pictured here) from the Elliot Hui laboratory at the University of California, Irvine, was the program’s inaugural winner. Learn more about Werner, his team and his research in the SLAS e-zine and this video.
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SLAS2017 Short Course Spotlight: Affinity-Based, Biophysical Methods for Screening and Mechanistic Studies — How to Effectively Use a Growing Biophysical Toolbox to Find and Characterize Chemical Leads
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Hear a rapid overview of the most relevant biophysics/label-free technologies for screening and lead finding/characterization, and then be challenged to effectively apply those technologies by looking at a range of common scenarios from different phases of lead discovery. This includes fragment-based drug discovery, hit validation and confirmation, in-depth hit characterization and support of high-throughput screening assay development.

Course instructors are Christine Genick of the Novartis Institutes for BioMedical Research Basel, Center for Proteomic Chemistry and Stefan Geschwindner of AstraZeneca R&D Mölndal, Discovery Sciences, Structure & Biophysics. "Affinity-Based, Biophysical Methods for Screening and Mechanistic Studies: How to Effectively Use a Growing Biophysical Toolbox to Find and Characterize Chemical Leads" is one of 21 short courses to be held at SLAS2017.
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A Step Forward in Building Functional Human Tissues
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Toward the ultimate goal of engineering human tissues and organs that can mimic native function for use in drug screening, disease modeling, and regenerative medicine, a Wyss Institute team led by Core Faculty member Jennifer Lewis, Sc.D., has made another foundational advance using three-dimensional (3D) bioprinting. This work builds upon their demonstrated ability to bioprint tissue constructs composed of multiple types of living cells patterned alongside a vascular network in an extracellular matrix. More


Scientists Discover 'Supramolecule' That Could Help Reduce Nuclear, Agricultural Waste
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Indiana University researchers have reported the first definitive evidence for a new molecular structure with potential applications to the safe storage of nuclear waste and reduction of chemicals that contaminate water and trigger large fish kills. The study, which was published online Oct. 6 in the German scientific journal Angewandte Chemie International Edition, provides experimental proof for the existence of a chemical bond between two negatively charged molecules of bisulfate, or HSO4. More


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Promiscuous Histone Mis-Assembly Is Actively Prevented by Chaperones
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Histone proteins are essential for the organization, expression, and inheritance of genetic material for eukaryotic cells. A centromere-specific H3 histone variant, centromere protein A (CENP-A), shares about 50% amino acid sequence identity with H3. CENP-A is required for packaging the centromere and for the proper separation of chromosomes during mitosis. Despite their distinct biological functions, previously reported crystal structures of the CENP-A/H4 and H3/H4 dimers reveal a high degree of similarity. More


Using Light to Move Electrons and Protons
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In some chemical reactions both electrons and protons move together. When they transfer, they can move concertedly or in separate steps. Light-induced reactions of this sort are particularly relevant to biological systems, such as Photosystem II where plants use photons from the sun to convert water into oxygen. To better understand how light can lead to the transfer of protons in a chemical reaction, a group of researchers have conducted adsorption studies on a new family of experiments to observe the transition that occurs when protons transfer between hydrogen-bonded complexes in solution. More




Multianalyte Antibiotic Detection on an Electrochemical Microfluidic Platform
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The excessive use of antibiotics in human and veterinary medicine causes the emergence of multidrug resistant bacteria. In this context, the surveillance of many different antibiotics provokes a worldwide challenge. Hence, fast and versatile multianalyte single-use biosensors are of increasing interest for many fields such as medical analysis or environmental and food control. Here we present a microfluidic platform enabling the electrochemical readout of up to eight enzyme-linked assays (ELAs), simultaneously. More


New Formulation of Ibuprofen May Be Superior for Pain Relief Than the Current Version
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Move over aspirin, a new formulation of ibuprofen might prove to be a "wonder drug." In a research report published online in The FASEB Journal, scientists used mice and rats to show that ibuprofen arginate may allow people to take higher doses without the cardiovascular side effects that are associated with current formulations found in over the counter products. In addition to being better tolerated, ibuprofen arginate also is released into the bloodstream more rapidly than the current formulations, likely providing faster pain relief. More


Putting a Human Cost on Endocrine Disruptors
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Long-term, low-level exposure to endocrine-disrupting chemicals costs the U.S. $340 billion in annual health care spending and lost wages, according to a study of epidemiological data. These compounds, commonly found in consumer products and their packaging and associated with pharmaceutical and agricultural chemical use, can interfere with hormone function and contribute to the development of a variety of diseases and health problems. More


Anti-inflammatory Therapy Shows Promise in Treatment of Depression
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Anti-inflammatory drugs similar to those used to treat conditions such as rheumatoid arthritis and psoriasis could in future be used to treat some cases of depression, concludes a review led by the University of Cambridge that further implicates our immune system in mental health disorders. Researchers from the Department of Psychiatry at Cambridge led a team that analyzed data from 20 clinical trials involving the use of anti-cytokine drugs to treat a range of autoimmune inflammatory diseases. More


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Johns Hopkins University Institute for NanoBioTechnology
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