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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit October 21, 2015

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Register for SLAS2016, Pay Your 2016 Dues, and Save $100
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It's a no-brainer! If you plan to participate in SLAS2016, just do the math: SLAS membership dues are $200, and dues-paying SLAS members receive $300 off SLAS2016 registration fees if they join/renew and register by Oct. 30.

In addition to $100 cash savings, SLAS members enjoy other discounts, advantages and year-round resources, such as subscriptions to the MEDLINE-indexed SLAS scientific journals, real-time and on-demand SLAS Webinars, access to the annual North American Survey of Laboratory Purchasing Trends and recordings of select scientific sessions from past conferences.
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SLAS Americas Council Election Underway
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Voting to elect two new members to fill open positions on the SLAS Americas Council is now underway. All dues-paying SLAS members from the Americas are eligible to vote, and should have received a separate e-mail with their personal membership information and a hyperlink to the online ballot. The voting process will be open through 11:59 pm CST on Nov. 5, 2015. Candidates for the SLAS Americas Council include:

John Thomas Bradshaw, Artel, Westbrook, ME
Neal Cosby, Promega Corporation, Sunnyvale, CA
Maureen Stone, Labcyte, Milwaukee, WI
Andrea Weston, Bristol-Myers Squibb, Wallingford, CT

Candidate statements and qualifications are publicly available. Please participate in this important process by casting your vote. If you have any questions or did not receive your voting invitation e-mail, please contact Brenda Dreier.
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Free at JBS Online: Understanding ForteBio's Sensors for High-Throughput Kinetic and Epitope Screening for Purified Antibodies and Yeast Culture Supernatant
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NEW and FREE review article at JBS Online. The authors from Adimab (Lebanon, NH) and Dartmouth College (Hanover, NH) say: "Without accurate, reliable kinetic and bin information, it is difficult to inform selection strategies in real time and confirm that affinity and activity goals are being met during the early stages of discovery. In an attempt to generate a biosensor type that would be compatible with a variety of germlines and sample types, we found that the custom b-AHFc sensors appeared to be robust working with both purified IgG and IgG supernatant, with little evidence of sensor-related artifacts."

This is a SAGE Choice article, allowing all readers immediate free access to the full manuscript.
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SLAS2016 Scientific Session Sneak Peek
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Browse the SLAS2016 Event Scheduler to learn about scientific session podium presentations like "Drug-Target Residence Time: Target Engagement, Target Vulnerability and Predictions of In Vivo Drug Activity" by Peter Tonge, Stony Brook University (Stony Brook, NY).

Predicting drug efficacy in humans remains a major barrier to the development of novel therapeutics. To improve the prediction of in vivo drug activity we propose that the kinetics of drug-target interactions, and in particular the life-time of the drug-target complex (residence time), should be integrated into predictive models since drug and target are not at equilibrium in vivo. In particular, drugs that dissociate slowly from their targets will have extended activity at low drug concentration thus mitigating a reduction in the frequency of dosing and hence an increase in therapeutic index. We have consequently developed a mechanistic PK/PD model that incorporates drug-target kinetics and have used this model to successfully predict efficacy in models of bacterial infection caused by Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. We believe that our approach, which is relevant across all disease areas, will have a profound impact on the development of new drugs.

Tonge presents Wednesday, Jan. 27, at 1:15 p.m. Image credit: National Human Genome Research Institute.
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Another Important Discovery from SLAS Endowed Fellowship Recipient
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Dean Ho's group at the UCLA School of Dentistry found that using nanodiamonds to fortify a material used in root canal procedures could significantly improve outcomes for patients. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don't entirely remove the infection, and residual infection after root canals can lead to tooth loss. Enter Ho's team and the development of two types of reinforced gutta percha: One strengthened with nanodiamonds and another strengthened with nanodiamonds that had been pre-loaded with antibiotics.

Details are published in "Nanodiamond–Gutta Percha Composite Biomaterials for Root Canal Therapy" in ACS Nano. SLAS established an Endowed Fellowship with Ho at UCLA in June 2012. Image Credit: American Chemical Society/Dong-Keun Lee.
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From the LabAutopedia Book List — Connectome: How the Brain's Wiring Makes Us Who We Are
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Author Sebastian Seung introduces us to the dedicated researchers who are mapping the brain's connections — neuron by neuron, synapse by synapse — in an attempt to discover the biological basis of identity.

The New York Times says about the book: "‎This is complicated stuff, and it is a testament to Dr. Seung's remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man."

Thanks to SLAS member Barry Bunin for this book suggestion.
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JALA and JBS VIP Meet & Greets at SLAS2016
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Say hello, ask questions and get to know the editors and authors of some of JALA and JBS's most innovative research. Meet JALA Editor-in-Chief Edward Kai-Hua Chow (National University of Singapore), JBS Editor-in-Chief Robert M. Campbell (Eli Lilly and Company), JALA Guest Editor Joe Olechno (Labcyte), JBS Guest Editor Jonathan Wingfield (AstraZeneca), JBS author David Beebe (University of Wisconsin) and JALA author Steve Riedmuller (Hudson Control Group).

Come to the SLAS Scientific Journals Information Station in the SLAS Member Center at scheduled times to enjoy face-to-face conversations about their work, your work and the new ideas shaping some of today's most promising research. Students especially can gain important insight and counsel from these accomplished professionals.
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Ancient Genome From Africa Sequenced for the First Time
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The first ancient human genome from Africa to be sequenced has revealed that a wave of migration back into Africa from Western Eurasia around 3,000 years ago was up to twice as significant as previously thought, and affected the genetic make-up of populations across the entire African continent. The genome was taken from the skull of a man buried face-down 4,500 years ago in a cave called Mota in the highlands of Ethiopia. More


Opening the Gates to Synthetic Cells
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Packaging drugs inside synthetic cells that can sense and respond to their environment, like real biological cells do, could open up new possibilities in targeted drug delivery. Now, for the first time, researchers have engineered a synthetic cell with a protein gate that opens to allow molecules to enter and interact with an enzyme. The system resembles biological cells, which control traffic using protein receptors and pores on their surfaces. More


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Automating Big-Data Analysis
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Big-data analysis consists of searching for buried patterns that have some kind of predictive power. But choosing which "features" of the data to analyze usually requires some human intuition. In a database containing, say, the beginning and end dates of various sales promotions and weekly profits, the crucial data may not be the dates themselves but the spans between them, or not the total profits but the averages across those spans. More


Bridging Adhesion of a Protein onto an Inorganic Surface Using Self-Assembled Dual-Functionalized Spheres
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
For the bridging adhesion of different classes of materials in their intact functional states, the adhesion of biomolecules onto inorganic surfaces is a necessity. A new molecular design strategy for bridging adhesion was demonstrated by the introduction of two independent recognition groups on the periphery of spherical complexes self-assembled from metal ions (M) and bidentate ligands (L). More




Concurrent Detection of Cellular and Molecular Cancer Markers Using an Immunomagnetic Flow System
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
We report a detection system for simultaneous measurement of cellular and molecular markers of cancer. Magnetic beads conjugated with antibodies against a specific antigen are used to capture both free molecules and whole cells overexpressing the antigen. The target-bound beads then flow through a microfluidic chamber where they are drawn to a glass surface by an external magnetic field. The cells and molecules captured on the surface are quantitatively analyzed using fluorescent microscopy. More


Stop-Motion View of Protein Folding Built from Album of Awkward Snaps
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
When proteins undergo folding, they move from one relatively stable conformation to another with extraordinary speed, so quickly, in fact, that the awkward intermediate conformations have always been thought to be beyond direct observation. Yet it turns out that these fleeting in-between states have been preserved in images of native proteins. And these images have been accumulating over the years, in the Protein Data Bank and other repositories, rather like snapshots of poorly posed family members in old photo albums. More


Organic Framework Serves as Catalyst for Photocatalytic Conversion of Water Into Hydrogen
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Humanity's need for energy is ever-increasing. However, the traditional energy sources are finite. In contrast, water and sunlight are available in vast abundance. Scientists at the Max Planck Institute for Solid State Research in Stuttgart and from LMU Munich have now created a material that uses light to produce the versatile energy source hydrogen from water. This polymeric photocatalyst is chemically stable. Moreover, the rate of hydrogen production can be fine-tuned by means of small structural modifications of the catalyst. More


New Hope for Alzheimer's Blood Test
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Autoantibodies in the blood may serve as powerful biomarkers for the early detection of Alzheimer's disease, Parkinson's, multiple sclerosis and breast cancer, Robert Nagele of the Rowan University School of Osteopathic Medicine said in a presentation at a meeting of the American Osteopathic Association in Orlando. All people harbor thousands of such autoantibodies in their blood, but neurodegenerative and other diseases can change that profile in a disease-specific manner, paving the way to a long-sought blood test for these conditions, Nagele said. More


Career


Postdoctoral Scholar
Johns Hopkins University School of Medicine
US – MD – Baltimore

Assistant Professor – Biological Engineering
Cornell University
US – NY – Ithaca

Research Advisor – Pharmaceutical Development Leader
Elanco Animal Health
US – IN – Greenfield

More jobs at SLAS Career Connections


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