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SLAS
SLAS2019 Conference Co-Chair John Doench, Ph.D., associate director of the Genetic Perturbation Platform and institute scientist at the Broad Institute of MIT and Harvard (Cambridge, MA, USA), believes in collaborative science. That's why he's at the Broad, and it is why he's dedicated to working with others at SLAS to be sure the SLAS International Conference and Exhibition delivers ideas and connections that enable scientists to make a difference. "Getting people to buy into the idea of collaborative science is a challenge," Doench says in a new article that appears in the SLAS Electronic Laboratory Neighborhood (SLAS ELN). "So much of how we think about science is about the individual. We talk about Nobel Prizes. We refer to studies by the last name of the first author. Once the paper is published, we refer to the results as from the PI in the lab — this lab did this, that lab did that. It's always focused on an individual person. That's not how you actually do most science." Photo by Len Rubenstein. Photography, courtesy of Broad Institute.
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SLAS
Attendees to the 2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic (Nov. 13-14, Boston, MA, USA) will enjoy digital poster presentations at the inaugural event. Learn more about innovations from poster presentations that will highlight compound storage solutions, understanding factors that drive throughput, web services that retrieve and store restriction data from multiple upstream master data sources, new acoustic liquid handling technology, through-plate dilution vs. plate dilution for dose response plating, growth of a world-class core research facility in Australia that will offer full compound management and logistics services and much more! See the complete scientific program and register now.
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SLAS
Leiden, the Netherlands, on a crisp fall morning. A great way to kick off the latest in the SLAS European symposium series: Advanced 3D Human Models and High-Content Analysis Conference. CORPUS Congress Centre, the amazing multi-story internal model of the human body, served as a metaphoric backdrop for the three-day event, which brought together instrument vendors, imaging specialists, data scientists, cell biologists and genomics specialists. Conferees reported an energetic, yet intimate, environment, lent by the space and the attendance numbers (just over 130). Talks were presented every day with major overarching themes: 3D culture enabling technologies, high-content screening, and stem cells and organoids.
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Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report , learn how viDA Therapeutics streamlined their processes and improved collaboration.
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SLAS
SLAS Technology guest editors seek manuscript proposals (abstracts) for three new special issues:
(SLAS Technology is formerly known as the Journal of Laboratory Automation.)
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SLAS
Pack your running shoes and join the popular non-competitive, early-morning 2019 SLAS FUNd Run as it returns to SLAS2019 (Feb. 2-6, 2019, Washington, D.C.) on Tuesday, Feb. 5. Participants will take part in a lively run or a brisk walk along the historic streets of D.C. with fellow SLAS2019 attendees to benefit the SLAS Educational Fund. The measured route for this run/walk is 4.54 miles or 7.3km on flat sidewalks throughout the city. Run for free or contribute $25 to receive an exclusive SLAS2019 FUNd Run T-shirt (please note that the coveted FUNd Run T-shirt is only guaranteed to participants who register in advance of SLAS2019 and supply a shirt size). Interested in sponsoring the 2019 SLAS FUNd Run? Your logo will appear on the run T-shirt, "fandana" and signage.
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
SLAS Discovery guest editors seek manuscript proposals (abstracts) for two upcoming special issues:
(SLAS Discovery is formerly known as the Journal of Biomolecular Screening.)
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SLAS
SLAS2019 International Conference and Exhibition
February 2-6, 2019
Washington, D.C., USA
Monday, Oct. 29: SLAS Student Poster Competition abstracts due
Wednesday, Oct. 31: SLAS Ignite Academic Collaboration Presentation abstracts due
Wednesday, Oct. 31: Member Only Registration Discount deadline
Thursday, Nov. 1: Exhibition-Only registration increases to $25
Thursday, Jan. 3, 2019: Deadline for Conference Hotels Discount (reservations made after this date will receive the group rate based only on individual hotel availability)
Monday, Jan. 21, 2019: Final Poster submission deadline
Sponsorship opportunities available!
SLAS Journals Special Issues Call for Papers
SLAS Technology: Engineering Innovations for Fundamental Biology and Translational Medicine
Friday, Oct. 26: Proposals due
Jan. 1, 2019: Invited submissions due
SLAS Discovery: Membrane Proteins – New Approaches to Probes, Technologies and Drug Design
Thursday, Nov. 1: Proposals due
March 1, 2019: Invited submissions due
SLAS Discovery: Advances in Cellular Target Engagement and Target Deconvolution
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
SLAS Technology: Flexible Analytical Devices for Point-of-Care Testing
March 1, 2019: Proposals due
July 1, 2019: Invited submissions due
SLAS Technology: Carbohydrate Structure Analysis: Methods and Applications
May 1, 2019: Proposals due
Aug. 10, 2019: Invited submissions due
LRIG Fall Meeting
Learn more about SLAS and its journals and enter to win a full conference registration for SLAS2019 at this upcoming LRIG chapter meeting (attendance is free, but preregistration is encouraged):
Tuesday, Oct. 30: LRIG Philadelphia Chapter Fall Vendor Exhibition
2018 SLAS Americas Sample Management Symposium: Managing Samples from Bench to Clinic
November 13-14, 2018
Boston, MA, USA
2019 Save the Date: 2019 SLAS Europe Conference and Exhibition
June 26-28, 2019
Barcelona, Spain
Exhibit and sponsorship opportunities available!
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Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Lab Manager
Spectrometers — devices that distinguish different wavelengths of light and are used to determine the chemical composition of everything from laboratory materials to distant stars — are large devices with six-figure price tags, and tend to be found in large university and industry labs or observatories.
A new advance by researchers at MIT could make it possible to produce tiny spectrometers that are just as accurate and powerful but could be mass produced using standard chip-making processes.
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Journal of the American Chemical Society
Late transition metal oxo complexes with high d-electron counts have been implicated as intermediates in a wide variety of important catalytic reactions; however, their reactive nature has often significantly limited their study. While some examples of these species have been isolated and characterized, complexes with d-electron counts >4 are exceedingly rare. Researchers report that use of a strongly donating tris(imidazol-2-ylidene)borate scaffold enables the isolation of two highly unusual CoIII-oxo complexes which have been thoroughly characterized by a suite of physical techniques including single crystal X-ray diffraction.
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Science Magazine
In chemistry, structure rules because it determines how a molecule behaves. But the two standard ways to map the structure of small organic molecules, such as pharmaceuticals, hormones and vitamins, have drawbacks. This week, two research teams report they've adapted a third technique, commonly used to chart much larger proteins, to determine the precise shape of small organic molecules. The new technique works with vanishingly small samples, is blazing fast and is surprisingly easy.
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Chemical & Engineering News
Few functional groups are as popular in synthesis as the carbonyl group. Composed of an oxygen molecule doubly bonded to carbon, the carbonyl welcomes reaction with all types of nucleophiles. Carbonyls will even accept electrophiles, but it takes some convincing. Chemists access this reversed reactivity by using single-electron strategies, which typically require strong, stoichiometric reductants to form a ketyl radical. Now, researchers have found a way to form ketyl radicals under much milder conditions.
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Genetic Engineering & Biotechnology News
If you could listen closely enough to Archaea, you might hear them busily shredding single-stranded DNA, most likely infectious material from a virus. And if you could look closely enough, you might see that the shredding tool used by the tiny organisms was a tiny Cas protein, not the big, bulky Cas9 protein so famous for its part in the CRISPR/Cas9 gene editing system, but another Cas9, a protein called Cas14.
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Laboratory Equipment
If we really want to know how our body's cells work — or don't work, in the case of disease — we might need to look beyond their genes and even beyond the proteins they are made of. We may need to start going through the cellular "trash."
A group led by Yifat Merbl, from the Weizmann Institute of Science, developed a system to do just that and found that "cellular dumpster-diving" contains information about the cell's function that is not otherwise seen.
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Phys.org
One of the hallmark traits of Alzheimer's disease, a debilitating disorder marked by memory deficits and general cognitive decline, is the accumulation in the brain of a protein called b-amyloid. These proteins form "plaques" and bind to unique proteins on the surface of brain cells called receptors, causing widespread cell death.
Now, UCLA researchers have discovered a drug that blocks b-amyloid plaques from attaching to brain cells, preventing the extensive cell death.
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Science Daily
University of Queensland-led research recreating 450 million-year-old enzymes has resulted in a biochemical engineering "hack" which could lead to new drugs, flavors, fragrances and biofuels.
Professor Elizabeth Gillam from UQ's School of Chemistry and Molecular Biosciences said the study showed ancient enzymes could survive high temperatures and that this could help create chemicals cheaply and at scale.
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Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity. SLAS Premier and Corporate Members get a discount on all new job postings.
Scientist I, High-Throughput Mass Spectrometry
Nurix Therapeutics
US – CA – San Francisco
Research Associate, Compound Management
Epizyme Inc.
US – MA – Cambridge
Postdoctoral Scientist Position in Alzheimer's Disease Research
Loma Linda University Medical Center
US – CA – Loma Linda
SLAS Discovery / SLAS Technology Publishing Manager
SLAS
US – IL – Oak Brook
Search Jobs at SLAS Career Connections
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