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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit October 26, 2016    SLAS2017    Moving? New job? Let SLAS know.      




Congratulations to SLAS Tony B. Academic Travel Award Winners!
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64 students from 14 countries will travel to SLAS2017 to present their scientific work Feb. 4-8 in Washington, DC. 11 of these students will deliver podium presentations and 53 will make poster presentations, including 4 students who were recognized as top poster presenters from SLAS Europe events earlier this year. Tony B. winners receive roundtrip travel, shared hotel accommodations and full conference registration.

The Tony B. Academic Travel Awards honor the late Tony Beugelsdijk, Ph.D., an inspirational and iconic leader in the field of life sciences discovery and technology who made an extraordinary impact on the SLAS community.


SLAS Europe: VIII Spanish Drug Discovery Network Meeting, Nov. 3-4, 2016
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Drug discovery and chemical biology professionals will gather in Santiago de Compostela, Spain on Nov. 3-4 to focus on the use of more predictive model systems throughout the discovery process, from early primary screening to preclinical and clinical studies, including:
  • The establishment and validation of advanced phenotypic model systems such as organoids
  • The intelligent choice of small molecule screening libraries to facilitate identification of important mechanisms in these systems
  • The latest methodologies for mechanism studies and target identification downstream of phenotypic screening
  • The progress toward more predictive animal models both from an efficacy and safety perspective
Register today!

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The Lab Man in SLAS ELN: Rational Screen Design — A Long-Lived Topic
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SLAS2017 Short Course instructor Ed Ainscow of Carrick Therapeutics provides insight to the SLAS2017 Rational Screen Design Session in the Assay Development and Screening Track in The Lab Man's latest article in the SLAS Electronic Laboratory Neighborhood e-zine.

"Fundamentally there is always a challenge in any screen to make sure you are finding the best lead candidates from a wide range of potential chemical space — and to do that in a speedy and cost efficient manner," Ainscow says. "Rational or intelligent screen design is an approach that uses one or more known attributes of either the screening system or the compound library to offer an alternative to the brute force approach of screening vast libraries of compounds."

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SLAS2017 Deadline Reminders
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SLAS looks forward to your participation Feb. 4-8 in Washington, DC! Browse and the SLAS2017 Event Scheduler for the latest information about scientific podium presentations, exhibitors, Short Courses, and the most up-to-date schedule of events. More

New Opportunity for SLAS Journal Authors to Increase Global Discoverability
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JALA and JBS authors now may choose to provide up to four translated abstracts (200 words each) for meta-tagged online publication with their accepted manuscripts for a fee of $200 each.

This opportunity helps authors increase readership and citations of their work by increasing online discoverability through Google and other international search engines that function in languages other than English.


SLAS2017 Short Course Spotlight: Data Management in the Age of Big Data, Mobile, and the Cloud
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This course brings you up to speed on the latest IT trends and cutting-edge technologies and how they might fit into your laboratory data landscape. Evaluate the suitability of cloud computing and understand its risks and benefits. Become aware of how to integrate mobile devices into your laboratory workflows. Understand how to store, manage and analyze your data using traditional and big data technologies. Survey applicable standards and architectures.

Burkhard Schaefer of BSSN Software has been an SLAS Short Course instructor for more than 15 years. He has been involved with the LECIS standardization effort at Los Alamos National Laboratory and the AnIML standardization project with the National Institute of Standards and Technology and the American Society for Testing and Materials.

Have You Visited the Neighborhood Lately?
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If you haven't been to the SLAS Electronic Laboratory Neighborhood e-zine lately, here's what you've been missing: More

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Exome Dataset Expands to Whole Genome
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With information from 126,216 human exomes and 15,136 whole human genomes, the Genome Aggregation Database (gnomAD), hosted by the Broad Institute of MIT and Harvard, has launched in beta. Members of the Exome Aggregation Consortium (ExAC), the leaders of gnomAD, have accumulated nearly "40 terabytes of raw variant data that need to be parsed for analysis," co-principal investigator Daniel MacArthur of the Broad announced at the American Society for Human Genetics (ASHG) annual meeting. More

Mechanically Flexible Organic Crystals Achieved by Introducing Weak Interactions in Structure: Supramolecular Shape Synthons
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Controlling mechanical properties of ordered organic materials remains a formidable challenge, despite their great potential for high performance mechanical actuators, transistors, solar cells, photonics, and bioelectronics. Here we demonstrate a crystal engineering approach to design mechanically reconfigurable, plastically flexible single crystals (of about 10) of three unrelated types of compounds by introducing active slip planes in structures via different noninterfering supramolecular weak interactions, namely van der Waals (vdW), π-stacking, and hydrogen bonding groups. More

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New Nanomedicine Approach Aims to Improve HIV Drug Therapies
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New research aims to improve the administration and availability of drug therapies to HIV patients through the use of nanotechnology. The research, conducted by the collaborative nanomedicine research program led by pharmacology professor Andrew Owen and materials chemistry professor Steve Rannard, from the University of Liverpool, examined the use of nanotechnology to improve the delivery of drugs to HIV patients. More

Unusual Hydrogen Bond Plays a Bigger Role in Proteins Than Chemists Realized
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Since the 1960s, chemists have known about an unusual type of hydrogen bond: one that can form between the amide hydrogen and the carbonyl oxygen in the same amino acid. But it's been hard to show that this interaction, called the C5 hydrogen bond, matters beyond amino acids, in proteins. Now, biochemistry professor Ronald T. Raines and graduate student Robert W. Newberry of the University of Wisconsin, Madison, report experimental and computational evidence that this hydrogen bond indeed helps stabilize proteins — significantly in some cases. More

Physicists Use Lasers to Capture First Snapshots of Rapid Chemical Bonds Breaking
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Lasers have successfully recorded a chemical reaction that happens as fast as a quadrillionth of a second, which could help scientists understand and control chemical reactions. The idea for using a laser to record a few femtoseconds of a molecule's extremely fast vibrations as it breaks apart came from Kansas State University physicists. Chii-Dong Lin, university distinguished professor of physics, and Anh-Thu Le, research associate professor in James R. Macdonald Laboratory, are part of an international collaborative project published in Science. More

Scientists Work Out Method to Create Unique Polymeric Membranes With Carbon Nanotubes    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In recent years, a large number of fundamental and applied studies have been dedicated to the properties of polymeric materials. In interactions with nanoparticles, the structures of polymers are transformed, which leads to a significant change of the physical properties of these materials; for example, the parameters of molecule diffusion changes. Such materials are considered promising for the modernization of membrane technologies for separation of gas and liquids. More

Study Reveals Potential New Strategy to Prevent Alzheimer's Disease
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Taking a pill that prevents the accumulation of toxic molecules in the brain might someday help prevent or delay Alzheimer's disease, according to scientists at Baylor College of Medicine, Texas Children's Hospital and Johns Hopkins University School of Medicine. The study, published in Cell Press journal Neuron, took a three-pronged approach to help subdue early events that occur in the brain long before symptoms of Alzheimer's disease are evident. The scientists were able to prevent those early events and the subsequent development of brain pathology in experimental animal models in the lab. More

Memory and Learning Gene Linked to Obesity
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Scientists have appreciated for some time the contribution of the central nervous system to metabolic disorders and obesity, yet the underlying molecular mechanisms have remained elusive. However now, a team of investigators from Baylor College of Medicine, the National Institutes of Health, and Virginia Tech Carilion Research Institute have discovered a new mechanism within the mouse brain that seems to regulate obesity. Moreover, the findings from this new study describe the new mechanism as having the potential to be targeted for treating obesity. More


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