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Certified UPS’s to protect your laboratory’s critical instrumentation and resolve current and potential power issues.
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See how the Thermo Scientific Versette automated liquid handler can meet your liquid handling needs!
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Asking and answering scientific questions using advanced tools and technology.
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 SLAS phenotypic drug discovery webinar next week
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"Phenotypic Drug Discovery Using Primary Human Cells and Co-Cultures: Lessons Learned" will be held live on Tuesday, Nov. 12, beginning at 11:30 ET. Ellen L. Berg, Ph.D., scientific director of BioSeek (a division of DiscoveRx), will talk about what makes a good phenotypic drug discovery screen and how to manage the data. This SLAS Webinar is free to dues-paid SLAS members; register today. Berg also is co-guest editor of the December 2013 and January 2014 two-part special issue of JBS on phenotypic drug discovery; many scientific manuscripts from the special issue are now online and available to SLAS Biomolecular Sciences Section members ahead-of-print.
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 From the SLAS President: SLAS.org refreshed and retooled
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Jeff Paslay, Ph.D., invites all to grab a cup of coffee and explore the new SLAS.org! Per Paslay, the revised site "demonstrates a new, streamlined approach to navigation that allows visitors to more easily identify and access the breadth of resources we have available on and through SLAS.org. At a glance, even first time visitors can easily recognize the energy and high-standards that have come to reflect SLAS, its mission and its members." Let SLAS know what you think — send an e-mail to new_site@slas.org.
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 Welcome to SLAS2014 Innovation AveNEW!
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Congratulations to the eight companies selected for Innovation AveNEW, that dedicated area of the Exhibit Hall hosting emerging and start-up companies offering promising new laboratory technologies. Truly representing SLAS’s global reach, SLAS2014 Innovation AveNEW companies are based in Canada, Ireland, Italy, The Netherlands and the United States.
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 New at JBS Online from upcoming special issue on phenotypic drug discovery
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To identify compounds that may lead to the development of better and safer medicines for sickle cell anemia, "we have established a method using primary human bone marrow day 7 erythroid progenitor cells (EPCs) to screen for compounds that induce γ-globin production." A team from GlaxoSmithKline, Collegeville, PA, published "Development of Phenotypic Screening Assays for γ-Globin Induction Using Primary Human Bone Marrow Day 7 Erythroid Progenitor Cells" now available only to SLAS Biomolecular Sciences Section members and JBS subscribers ahead-of-print.
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Let Multispan be your one-stop shop partner from cell line and
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Life Chemicals specializes in organic synthesis for Drug Discovery. We provide compound libraries for HTS, collections of fragments, targeted libraries, building blocks and custom synthesis services.
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 Use the SLAS2014 Event Scheduler to maximize your time in San Diego
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The SLAS2014 Event Scheduler allows you to review scientific program abstracts, view exhibitor listings and Exhibit Hall layout, and utilize robust search options. With the handy "My Itinerary" function, you can build a personalized schedule of activities to organize your time at SLAS2014, Jan. 18-22, San Diego. Explore the SLAS2014 Event Scheduler today!
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Weigh the substance AND the solvent using Quantos automated dispensing systems from METTLER TOLEDO. Preparing accurate concentrations using gravimetric dosing complies with the latest USP guidelines <841>. It offers the benefits of improved quality of results; enhanced user safety; guaranteed process security; and minimized substance and solvent consumption.
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The xCELLigence RTCA-DP System monitors cell migration/invasion using a noninvasive label-free impedance-based technology. This walk-away system allows you to measure cell invasion and migration continuously in real time over the entire time course of an experiment. Visit us at www.aceabio.com.
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Get results fast with Hamamatsu’s FDSS µCELL, an imaging-based microplate reader. This affordable, simple-to-use reader accommodates 96- or 384-well microplates for kinetic cell-based assays such as GPCR, ion channel, prolyl isomerase, transporter, and light-activated receptor or channel assays. Click here for more info.
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SLAS Career Connections in San Diego
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Take advantage of a full menu of career-enhancing programs designed exclusively for life science R&D professionals at SLAS2014 in San Diego. Workshop participation and personal coaching opportunities are limited and available on a first come, first served basis.
- Mentoring and career advice from American Chemical Society (ACS) San Diego Chapter members
- Mock Interviews: Preparation and Practice for Getting the Jobs You Want Workshop presented by Dan Eustace, Ph.D., University of Connecticut
- Not Networking 101: Building Relationships for Success Workshop presented by Joanne Kamens, Ph.D., Addgene
- One-on-One career coaching conducted in private by ACS mentors, Eustace and Kamens
Contact mgeismann@slas.org to schedule.
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Using breath-borne biomarkers for 'discovery' of the human exposome
Analytical Chemistry Share
According to recent research, 70−90 percent of long-term latency and chronic human disease incidence is attributable to environmental (human exposome) factors through the gene−environment interaction. Environmental exposure science is now embarking on a new "discovery" path for decoding the human exposome using biomarkers in breath and other biological media.
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Proteins in their natural habitat
Phys.org Share
Proteins which reside in the membrane of cells play a key role in many biological processes and provide targets for more than half of current drug treatments. These membrane proteins are notoriously difficult to study in their natural environment, but scientists at the University of Oxford have now developed a technique to do just that, combining the use of sophisticated nanodiscs and mass spectrometers.
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'Bubble kid' success puts gene therapy back on track
New Scientist Share
Most parents dream of a 5-week-old baby who sleeps through the night, but Aga Warnell knew something was wrong. Her baby, Nina, just wasn't hungry in the way her other daughters had been. Within weeks, Nina became very ill, says her father, Graeme. She was admitted to hospital with a rotavirus infection. Then she picked up pneumonia. It turned out Nina had a condition called severe combined immunodeficiency.
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Scigilian is a software company specializing in offering solutions to the problems encountered in pharmaceutical research, biotechnology, and contract research. Trusted, from large pharma to small CRO.
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Brain cells a mixed bag, genetically
Genetic Engineering & Biotechnology News Share
Scientists using single-cell genomics have found that human neurons display a surprising degree of genetic diversity. This finding reinforces recent studies of neuronal genomes that have revealed extra or missing chromosomes, or pieces of DNA that can copy and paste themselves throughout the genomes. Moreover, it suggests that a simplified view of a cell's individuality — the idea that each cell has the same DNA as other cells but differs because of how its DNA is read — exaggerates the degree of perfection attained by our genes.
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Making hydrogen
Chemical & Engineering News Share
If scientists can figure out how to tap the power of the sun to convert cheap, abundant resources to valuable fuels such as hydrogen, and do so in an inexpensive and sustainable way, they will have taken a big step toward solving the world's energy problems. The potential payoff is driving a worldwide effort to find a practical light-driven way to split water and extract hydrogen, an environmentally friendly fuel.
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Cutting edge: What's new in pharmaceutical R&D
By Rosemary Sparacio Share
 It is clear that pharmaceutical companies are tackling serious diseases in therapeutic areas that heretofore were more challenging. But new technology has changed that landscape forever. And patients with diseases like cystic fibrosis, cancer, celiac disease and Crohn's disease — just to name a few — now have a wide variety of drugs to look forward to in the near future. Many pharmaceutical companies are forming alliances with significant monetary investments to improve both their product lines and their bottom lines.
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New chemistry: Drawing and writing in liquid with light
Science Daily Share
University of Helsinki researchers have manufactured photochemically active polymers which can be dissolved in water or certain alcohols. The new soluble, photosensitive polymer was created by doctoral student Szymon Wiktorowicz. In the study, a 365-nm laser was aimed at a solution into which the polymer was partially dissolved. When exposed to light, the polymer switched to its cis conformation, dissolving completely and leaving a clear form which was visible in the cloudy solution.
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Crafting a better enzyme cocktail to turn plants into fuel faster
Bioscience Technology Share
Scientists looking to create a potent blend of enzymes to transform materials like corn stalks and wood chips into fuels have developed a test that should turbocharge their efforts. The new research, published in October in the journal Molecular BioSystems, is part of a worldwide effort to create fuels from plants that are plentiful and aren't part of the food supply. It's possible to do this today, but the process is costly, laborious and lengthy.
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Metallo-supramolecular cyclic polymers
Journal of The American Chemical Society Share
Cyclic brush polymers represent an exciting new macromolecular topology. For the first time, this new topology has been combined with metallo-supramolecular interactions to construct novel cyclic brush polymers. Here, ring-expansion metathesis polymerization was used to synthesize a universal cyclic template with a polynorbornene backbone, which was further modified with the metal-chelating synthon terpyridine.
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BMG LABTECH is releasing its newest instrument, the CLARIOstar, a high performance microplate reader with advanced monochromators, spectrometer, and filters. With this cutting-edge, hybrid technology, the CLARIOstar offers clear superiority with unparalleled flexibility and sensitivity.
Anything is possible with BMG LABTECH’s CLARIOstar. Any wavelength. Any bandwidth. Any assay.
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Introducing AusWasher MTP, a plate washer with residual volume < 0.01µl, enabling the highest specificity ELISA in 96, 384,1536 well plates with dramatically reduced number of wash steps. Centrifugation eliminates aspiration of wash buffer: no clogging, uniform buffer removal, no damage from physical contact with needles. Available standalone and OEM.
Info: Wolfgang Mann wmann@ausbio.de
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The Prestwick Chemical Library moves into its 14th year of leading the industry with its collection of 1,280 approved drugs available in multiple formats. Applications range from assay development and calibration to single substance and combination screens. Prestwick also provides follow-up chemistry services for lead discovery and optimization.
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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Dennis Hall, Senior Content Editor, 469.420.2656
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