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65 Achievers Earn SLAS Tony B. Academic Travel Awards for SLAS2018
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Sixty-five exceptional undergraduate and graduate students, post-doctoral researchers and junior faculty members earned invitations to present their scientific achievements at SLAS2018 as part of the SLAS Tony B. Academic Travel Award program. The award provides roundtrip travel, shared hotel accommodations and full conference registration to these early career researchers from 15 different countries.
"With an investment of nearly half a million dollars (from 2010 through 2017), the Tony B. program reflects a serious commitment to the next generation of scientific thought-leaders," says SLAS President Scott Atkin. "This investment does much more than cover the cost of airfare and hotel rooms. It is invigorating science, extending collaboration networks and building a stable path forward for our Society."
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In Vitro Tissue Microarrays for Quick and Efficient Spheroid Characterization
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This free, ahead-of-print SLAS Discovery original research report describes a new technology that bridges the gap between clinical pathology assessment, high-content analysis and 3D cell cultures. With the spheroid microarray technique scientists can probe spheroid phenotype, multiplex readouts and analyze the results at the single cell level.
The method arranges 66 spheroids in a gel array for paraffin-embedding, sectioning and immunohistochemistry. The process is rapid, automatable and uses 11 times fewer reagents compared to conventional workflows.
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New SLAS Webinar: How AstraZeneca is Revolutionizing Sample Management with Acoustic Tube-Based Technologies
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Learn about AstraZeneca's vision to enhance their sample management capabilities by standardizing on acoustic liquid handling throughout sample storage and screening preparation workflows. Kevin Cross, senior scientist, sample management at AstraZeneca, discusses the benefits of adopting the new acoustic tube technology and how AstraZeneca is approaching integration into its sample management infrastructure. Justin Jager, product manager, lab automation at Labcyte, provides an overview of the new automated system and highlights how it addresses the needs of sample management teams at AstraZeneca.
This SLAS Webinar, to be held live Dec. 12 and then available on demand, is open to members and non-members alike.
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The Lab Man: Practical Phenotypic Screening Instruction at SLAS2018
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"Phenotypic screening has come back as a serious strategy for drug discovery," says SLAS2018 Short Course instructor Fabien Vincent of Pfizer. "As an unbiased (or less biased) approach, it can reveal completely novel biological mechanisms at play in disease, allowing scientists to work on unique targets and develop these novel, first-in-class medicines."
Vincent and fellow experts Jonathan Lee of Eli Lilly and David Swinney or iRND3 are teaching "Phenotypic Screening: Why, When and How" at SLAS2018 on Sunday, Feb. 4. The Lab Man's article in the SLAS Electronic Laboratory Neighborhood highlights other SLAS efforts to explore phenotypic drug discovery, including the two-part issue of JBS (now SLAS Discovery), and 2013 SLAS Webinar series.
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Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report, learn how viDA Therapeutics streamlined their processes and improved collaboration.
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A Message from Dean Ho, SLAS Endowed Fellowship Recipient
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Researchers at the UCLA School of Dentistry and the UCLA Henry Samueli School of Engineering and Applied Science found in a clinical trial that nanodiamonds protected disinfected root canals after the nerve and pulp were removed, thereby improving the likelihood of a full recovery. The findings, a milestone for the use of nanodiamonds in humans, was published in the Oct. 23 issue of Proceedings of the National Academy of Sciences.
According to Ho, "the work acknowledges support from the SLAS Endowed Fellowship that was provided to my team upon arrival to UCLA. Thanks very much for the very helpful support for my R&D program. Bringing our technologies directly to patients to enhance their treatment outcomes has always been the primary objective of my team. SLAS's support has made that a reality."
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Planning a Vacation Around SLAS2018?
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Can you add a couple days on either side of SLAS2018? San Diego will not disappoint! SLAS2018, held at the San Diego Convention Center, overlooks spectacular Coronado Bay, filled with colorful sailboats, spectacular yachts and one massive aircraft carrier. Walk three blocks and discover urban galleries, restaurants and boutiques.
Just a few minutes north, south, east or west, you can find not only the world's busiest border crossing, rural orchards, ranches and small-town America set against a dramatic North American desert, but world-class biomedical research centers, rolling green hills, seaside restaurants and exquisite Pacific sunsets.
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Modeling Surface Chemistry, Predicting New Materials
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The ruddy flakes of a rusted nail are a sure sign that an undesirable chemical reaction has occurred at the surface. Understanding how molecules and atoms behave with each other, especially at surfaces, is central to managing both desirable chemical reactions, such as catalysis, and undesirable reactions, like a nail's corrosion. Yet the field of surface chemistry has been challenged for nearly 100 years to develop predictive theories for these reactions. Now there's progress, thanks to a new approach.
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Tetrapetalones Yield to Total Synthesis at Last
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Several research groups have been trying to synthesize the tetrapetalones, a family of natural products isolated from Streptomyces bacteria, for over a decade. Eighteen students have published dissertations detailing their attempted syntheses. But no one reached the goal — until now. John L. Wood and coworkers at Baylor University have achieved the total synthesis of two family members: tetrapetalones A and C.
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Subset of Stem Cells Identified as Source for All Cells in Blood and Immune Systems
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Researchers at Fred Hutchinson Cancer Research Center have identified a specific subset of adult blood stem cells that is exclusively responsible for repopulating the entire blood and immune system after a transplant.
The discovery, to be published in Science Translational Medicine, has the potential to revolutionize blood stem cell transplantation as well as the delivery and targeting of cell and gene therapies that use healthy versions of the self-renewing stem cells to replace ones that are diseased.
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New Drug Shows Potential as a Different Kind of Antidepressant in Mouse Trials
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A potential new antidepressant and antianxiety treatment with a unique mechanism of action has been developed by scientists at the University of Bath.
The compound has shown significant potential after studies in mice. The research is published in the British Journal of Pharmacology.
Around one in six adults will experience depression in their lifetimes. New drugs to treat depression in particular are needed because many existing antidepressants don't work in up to 50 percent of patients.
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Hear Epizyme's Elizabeth Admirand review their reasons for choosing Titian's Mosaic sample management software to solve their research need for accurate compound inventory and tracking of Epizyme's biological samples.
Are you looking to upgrade your compound management? Talk to the experts at Titian Software.
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New Evidence That Dengue Antibodies Trigger Life-Threatening Infections
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It's a disease theory fit for a spy novel: Protective antibodies can turn double agent, teaming up with the dengue virus to make an infection more severe, even life-threatening. First proposed more than 40 years ago, antibody-dependent enhancement (ADE) has won over many doubters but still has impassioned skeptics. Now, a finding from a large, long-term study in Nicaraguan children adds compelling evidence that ADE is real.
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RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder
The Scientist Share
Alnylam Pharmaceuticals is reporting positive results from a clinical trial using patisiran — an RNA interference (RNAi) drug — to treat patients suffering from hereditary amyloidosis with polyneuropathy, a life-threatening genetic disorder. Alnylam has announced it plans to file for approval in the U.S. by the end of the year. If this goes through, patisiran would become the first RNAi therapeutic on the market.
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Researchers Report First-Ever Protein Hydrogels Made in Living Cells
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Johns Hopkins cell biologists report what they believe is the first-ever creation of tiny protein-based gelatin-like clumps called hydrogels inside living cells. The ability to create hydrogels on demand, they say, should advance the long scientific struggle to study the elusive structures — which form in nature when proteins or other molecules aggregate under certain conditions — and to uncover their suspected contributions to human diseases.
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Lab-Designed Molecules Offer New Approach to Treating Superbug Infections
Genetic Engineering & Biotechnology News Share
A scientific team including researchers from the Spanish National Research Council (CSIC) says it has made a significant advance against superbugs and their resistance to multiple drugs. The group designed molecules that can disrupt the cellular mechanisms that lead these bacteria to becoming unaffected by conventional antibiotics. The study ("Membrane Microdomain Disassembly Inhibits MRSA Antibiotic Resistance") appears in Cell.
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