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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit November 9, 2016

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SLAS ELN Reports: Dana Vanderwall — Conquering Data Space
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"Sometimes we have to draw from areas outside our own domain for perspective and expertise. For example, some of the key measures we use to study similarities between molecules, clustering molecules or understanding a large data space actually come from psychology and sociology," Dana Vanderwall, Ph.D., says. "Social sciences algorithms and the thought that goes into them doesn’t have anything to do with drug discovery or the kind of data we produce in the lab, but it can fuel our problem-solving."

Read more about the Bristol-Myers Squibb director of biology and preclinical IT and SLAS2017 co-chair in the SLAS Electronic Laboratory Neighborhood e-zine.
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Boyd, Kirkpatrick and Jochems Appointed to SLAS Europe Council
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Helen Boyd, Peter Kirkpatrick and Gijs Jochems begin three-year terms of service on the SLAS Europe Council at SLAS2017. Boyd is acting director reagents and assay development at AstraZeneca, Sweden; Kirkpatrick is chief editor of Nature Reviews Drug Discovery, U.K.; and Jochems is general manager at Promega Biotech Iberica, Spain.

They join four current members of the council to guide member services and ensure SLAS delivers on its mission in Europe.
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SLAS Journal Special Issues: Call for Abstracts
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Special issues of SLAS Discovery (JBS) and SLAS Technology (JALA) are hallmarks of editorial excellence, popular with readers and highly cited. Manuscript proposals (abstracts) for original research reports, reviews, perspectives and technical notes/technology briefs are now being accepted for special issues on these important topics:

Statistical Applications in Knowledge and Drug Discovery
Quantitative Imaging in Life Sciences and Biomedical Research
DNA-Encoded Chemical Library Technologies: Screening and Hit Identification
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SLAS Europe: VIII Spanish Drug Discovery Network Meeting
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More than 110 drug discovery and chemical biology professionals from nine countries gathered Nov. 3-4 in Santiago de Compostela, Spain, to focus on the use of more predictive model systems throughout the discovery process — from early primary screening through clinical studies.

Keynote presentations were "Novel Models in Drug Discovery and Research Ecosystem Alliances" by Carlos R. Plata-Salaman, chief scientific officer and chief medical officer, ESTEVE; and "Chemical Biology Approaches for Target Deconvolution" by Kilian Huber, principal investigator, Target Discovery Initiative, Structural Genomics Consortium. "SLAS is especially grateful to the Scientific Committee for putting together such a remarkable program," said SLAS Europe Director Caroline Gutierrez in the meeting's closing remarks. View photos on Facebook.
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Applications Due Nov. 16 for $100K SLAS Graduate Education Fellowship Grant
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"As a student starting my career, getting a fellowship like this is very encouraging," says Erik M. Werner, winner of the inaugural SLAS Graduate Education Fellowship Grant and member of Elliot Hui laboratory at the University of California, Irvine. "It is also a great opportunity for me to connect with other people and ideas in my field."

The SLAS grant program facilitates educational opportunities for outstanding students pursuing graduate degrees related to quantitative biosciences and/or life sciences research and awards up to $50,000 per year, for a maximum of two years, to qualified educational institutions. Applications for the 2017 grant are due Nov. 16. Learn more about Werner, his team and his research in the SLAS e-zine and this short video.
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SLAS2017 Short Course Spotlight: Establishing Cell-Based Assays for Screening
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Learn about developing standard procedures for handling cultured cells to set up cell-based assays, techniques for measuring cell health and the pathways leading to cytotoxicity, developing siRNA screening assays and also hear an overview of various GPCR screening methods. Course instructors are Terry Riss of Promega Corporation, Lisa Minor of In Vitro Strategies, Geoffrey Bartholomeusz of the University of Texas M.D. Anderson Cancer Center and Eric N. Johnson of WuXi AppTec.

"Establishing Cell-Based Assays for Screening" is one of 21 short courses to be held at SLAS2017.
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SLAS2017 Preliminary Program Now Available
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SLAS2017, planned and presented by life scientists for life scientists and taking place in Washington, DC, Feb. 4-8, provides the opportunity to fast-track your knowledge and professional connections to become an even more valuable asset to your organization.

The SLAS2017 preliminary program is your A-to-Z guide to five days of immersive activities offering the latest research, peer perspectives and tools to stay ahead of the curve. Browse the preliminary program today.
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Airway-on-a-Chip Smokes Cigarettes to Study Respiratory Disease
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A microfluidic device has started smoking to give researchers a new window on one of the world's leading causes of death. Developed by Donald E. Ingber's team at Harvard University's Wyss Institute, the device uses a mechanical respirator to "inhale" cigarette smoke and pass it through a microfluidic airway lined with living human cells. The researchers engineered the system to mimic human smoking habits and found that it produces the same biochemical hallmarks observed in smokers with chronic obstructive pulmonary disease, or COPD. More


Electrocatalytic Hydrogen Evolution under Acidic Aqueous Conditions and Mechanistic Studies of a Highly Stable Molecular Catalyst
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Electrocatalytic activity of a water-soluble nickel complex, [Ni(DHMPE)2]2+ (DHMPE = 2-bis(di(hydroxymethyl)phosphino)ethane), for the hydrogen evolution reaction (HER) at pH 1 is reported. The catalyst functions at a rate of ∼103 s–1 (kobs) with high Faradaic efficiency. Quantification of the complex before and after 18+ hours of electrolysis reveals negligible decomposition under catalytic conditions. More


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New Computational Tool May Speed Drug Discovery
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Proteins are the molecular workhorses of biology — they carry out the instructions written in the genetic code. Their shape plays a crucial role in their function and their ability to interact with other molecules. Scientists study these interactions to develop new insights into protein function and to develop targeted therapies for diseases such as cancer. More


Exome Dataset Expands to Whole Genome
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With information from 126,216 human exomes and 15,136 whole human genomes, the Genome Aggregation Database (gnomAD), hosted by the Broad Institute of MIT and Harvard, has launched in beta. Members of the Exome Aggregation Consortium (ExAC), the leaders of gnomAD, have accumulated nearly "40 terabytes of raw variant data that need to be parsed for analysis," co-principal investigator Daniel MacArthur of the Broad announced. More


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Researcher Develops Safer Gene Therapy
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A Washington State University researcher has developed a way to reduce the development of cancer cells that are an infrequent but dangerous byproduct of gene therapy. Grant Trobridge, an associate professor of pharmaceutical sciences, has altered the way a virus carries a beneficial gene to its target cell. The modified viral vectors reduce the risk of cancer and can be used for many blood diseases. More


New Advance in RNA Studies Holds Out Hope for Cancer Drug Development
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An international research team led by the University of Leicester has made a breakthrough advance that could pave a new route for the development of anti-cancer drugs. The advance is announced in an online publication in Nature Chemical Biology. The Leicester team members say they are delighted by their finding which could lead to new anti-cancer drugs thanks to "wonderful interdisciplinary collaboration involving biochemists and chemists from England, Scotland, France and USA." More


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Researchers Show Genetic Variants and Environmental Exposures Have Influence on Health
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Scientists at the Wayne State University School of Medicine's Center for Molecular Medicine and Genetics have shown for the first time the extent by which interactions between environmental exposures and genetic variation across individuals have a significant impact on human traits and diseases like diabetes, heart disease and obesity, strengthening the case for precision medicine initiatives. More


Two Wrong Genes Can Make a Right, but When? Rules Emerge
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The enemy of my enemy is my friend — this ancient concept explains many peculiar and even unsavory alliances. And it applies not just to affairs of state, but to the genome, where a potentially deleterious mutation can be effectively neutralized by a second mutation, a suppressor mutation. Until recently, suppressor mutations were all but unknown. Recruiting them to fight disease-causing mutations was hardly a possibility. More




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Scientific Leader, Platform Biology Automation
GSK
US – PA

Scientist/Engineer 1-3, Automation
Just Biotherapeutics
US – WA – Seattle

Biotechnology Associate
Yale University
US – CT – New Haven

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