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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit November 11, 2015

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SLAS Webinar Nov. 18: Genetic Control System Design and Engineering for Synthetic Biology
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Next week, James M. Carothers of the University of Washington Center for Synthetic Biology and Molecular Engineering & Sciences describes approaches for combining advanced computational simulations with massively-scaled experimental analysis to test the limits of what can be accomplished through genetic control system design and enable production of medically and industrially relevant materials.

The Nov. 18 SLAS Webinar, presented by JALA and JBS, the official journals of SLAS, is free to SLAS dues-paying members.
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SLAS Nominations Committee Endorses New Members for 2016 SLAS Board of Directors
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The SLAS Nominations Committee endorses Peter Grandsard of Amgen (USA), Ian Shuttler of Tecan Trading (Switzerland) and Elisabeth (Sabeth) Verpoorte, Ph.D., of the University of Groningen (Netherlands) for three-year terms of Board service beginning January 2016. Grandsard, Shuttler and Verpoorte were selected for the breadth and depth of experience they will bring to the SLAS Board of Directors.

In accordance with SLAS Policy, if no valid petition nominating alternate candidates is received by Dec. 10, 2015, the appointment of these three individuals will be moved forward to the current Board for official acclamation.
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SLAS2016 Scientific Session Sneak Peek
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Browse the SLAS2016 Event Scheduler to learn about scientific podium presentations like "Continuing the Quest for a Mass Spectrometry-Based Plate Reader: Evaluating Laser Diode Thermal Desorption (LDTD) coupled with Nanoliter Dispensing for HTS and HT-ADME Applications" by Andrew Wagner, Bristol-Myers Squibb (Wallingford, CT).

Assays that utilize mass spectrometry (MS) for analysis are both sensitive and selective while offering the ability to provide label-free detection of physiologically relevant substrates and products. MS-based methodologies, however, have traditionally relied upon liquid chromatography or on-line solid phase extraction as front-end sample delivery mechanisms. Because of this, they typically have slow cycle times that aren't amenable to high-throughput screening efforts. Using newer approaches that employ laser desorption techniques to directly introduce the contents of wells into the mass spectrometer, it is possible to achieve throughputs that approach those of plate-reader assays and meet the demands of early discovery screening applications. Here we investigated the approach of coupling nanoliter sample deposition with Laser Diode Thermal Desorption — tandem mass spectrometry (MS/MS) and evaluated its utility in providing an ultra high-throughput, label-free detection method for various applications.

Wagner presents at SLAS2016 on Monday, Jan. 25, at 4 p.m. His work also is featured ahead-of-print at JBS Online.
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More Kudos for SLAS Endowed Fellowship at UCLA Discovery
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The Economist published "Tooth Fairy-Dust" about new work at the UCLA School of Dentistry. SLAS President Dean Ho and his group are using nanodiamonds to fortify a material used in root canal procedures, which could significantly improve outcomes for patients.

"Nanodiamond–Gutta Percha Composite Biomaterials for Root Canal Therapy" is published in the Oct. 9 issue of ACS Nano. SLAS established an Endowed Fellowship with the UCLA School of Dentistry in June 2012. Image Credit: American Chemical Society/Dong-Keun Lee.
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From the LabAutopedia Book List — Applied Minds: How Engineers Think
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Author and engineer Guru Madhavan introduces the concept of modular systems thinking, describing how his profession sees structure where there is none and how engineers transform problems into opportunities.

"The heroes of Guru Madhavan's compact book about the logical habits of engineers are not the usual suspects of the iPhone era," says Wall Street Journal book reviewer Jon Gertner. "With barely a mention of Wozniak or Jobs, the author takes us back to an earlier time so that we can witness the solving of problems that have long since gone away."
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Have You Made Your Hotel Reservation for SLAS2016?
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SLAS has negotiated discounted rates for SLAS2016 participants at three premier hotels — the San Diego Marriott Marquis & Marina (Headquarters Hotel), the Hilton San Diego Bayfront and the Omni San Diego Hotel. All three hotels are within easy walking distance of the San Diego Convention Center.

Staying at an official SLAS2016 hotel and booking through approved channels keeps you in the center of SLAS activity and ensures optimum discounts and special perks like free internet and fitness center access. The deadline for reserving your room at the SLAS2016 rate is Dec. 24, 2015.
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Computers Used to Tackle One of Chemistry's Greatest Challenges
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Researchers from the University of Bradford have joined forces with German high-tech company, Avant-garde Materials Simulation, to successfully predict the crystal structures of small organic molecules by computational methods without experimental input. These findings were revealed in the 6th blind test of crystal structure prediction, an exercise conducted by 25 international research groups that was organized by the Cambridge Crystallographic Data Centre. More


Cryo-Electron Microscopy Breaks the Crystal Ceiling
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The king and queen of protein structure determination have, for years, been X-ray crystallography and nuclear magnetic resonance spectroscopy. But now there's a challenger to the throne. This upstart is cryo-electron microscopy. Cryo-EM's ability to tackle samples that can't be crystallized has allowed it to provide structures that the reigning methods have been slow to crack. Meanwhile, the march toward ever-more-powerful computing has edged this technique closer to atomic resolution, producing detailed structures that reveal every nook and cranny of a molecule. More


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Scientific Research is Conservative but Could be Accelerated
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Institutional and cultural pressures lead scientists to avoid risk-taking and choose inefficient research strategies, two new University of Chicago papers conclude. Despite increased opportunities for groundbreaking experiments, most scientists choose conservative research strategies to reduce personal risk, which makes collective discovery slower and more expensive. However, these computational studies also uncovered more efficient approaches for maximizing discovery and identified the approaches used more often by scientists who have won Nobel Prizes and other prestigious awards. More


New Method Identifies Up to Twice as Many Proteins and Peptides in Mass Spectrometry Data
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An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches. The method can be applied to a range of fields, including clinical settings and fundamental biology research for cancer and other diseases. The key to the new method's improved performance is its ability to compare data to so-called spectral libraries — essentially a pattern-matching exercise — rather than individual spectra or a database of sequences. More


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Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Almost all known members of the cytochrome P450 (CYP) superfamily conserve a key cysteine residue that coordinates the heme iron. Although mutation of this residue abolishes monooxygenase activity, recent work has shown that mutation to either serine or histidine unlocks non-natural carbene- and nitrene-transfer activities. Here we present the first crystal structure of a histidine-ligated P450. More


Researchers Zero In on Cellular Stress Link to Heart Disorders
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Scientists at Duke Medicine have identified a novel molecular pathway involved in heart attacks and death from heart disease. The researchers, who published a study, "Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis," in PLOS Genetics, found that stress on the endoplasmic reticulum is associated with risk of future heart events, and it can be detected in bits of molecular detritus circulating in the blood. More




Cancer Researchers Band Together to Pool Tumor Genome Data
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It's the latest hope offered to many patients at major cancer research centers: Let us sequence your tumor, and maybe we can match it to a drug that will beat back the malignancy. But the reality is that genomic analysis still only helps a small fraction of cancer patients. "More often than not, we don't know what to do with the information," says Charles Sawyers, a researcher at Memorial Sloan Kettering Cancer Center in New York City. Now, several large U.S. and European academic medical centers are hoping to change that. More


Nanoparticle Delivery Maximizes Drug Defense Against Bioterrorism Agent
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Scientists from the California NanoSystems Institute at UCLA have developed a nanoparticle delivery system for the antibiotic moxifloxacin that vastly improves the drug's effectiveness against pneumonic tularemia, a type of pneumonia caused by inhalation of the bacterium Francisella tularensis. The study, which appears in the journal ACS Nano, shows how the nanoparticle system targets the precise cells infected by the bacteria and maximizes the amount of drug delivered to those cells. More


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Career


Director Research & Development
Pacific Biomarkers
US – WA – Seattle

Automation Associate
Regeneron Pharmaceuticals, Inc.
US – NY – Tarrytown

Global Registration Specialist
Microban International, Ltd.
US – NC – Huntersville

More jobs at SLAS Career Connections


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