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JBS special issue on phenotypic drug discovery now online
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SLAS Biomolecular Sciences Section members and JBS subscribers can now view the December issue, including 13 original research articles such as "The Contribution of Mechanistic Understanding to Phenotypic Screening for First-in-Class Medicines" by David Swinney and "Development of High-Content Assays for Kidney Progenitor Cell Expansion in Transgenic Zebrafish" by Subramaniam Sanker et al.

This is part one of a two-part special issue on modern PDD, or physiology-based, strategies by guest editors Jonathan A. Lee and Ellen L. Berg.
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JALA special issue on advancements in biomedical micro/nano tools and technology now online
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"Hybrid Microfabrication of Nanofiber-Based Sheets and Rods for Tissue Engineering Applications" and "Development of a Multiplexed Microfluidic Platform for the Automated Cultivation of Embryonic Stem Cells" are among the original reports in the December special issue, part one of a two-part special issue.

SLAS Laboratory Automation Section members and JALA subscribers can view the issue online now.

Also new online is the JALA podcast with the three authors of "Circulating Tumor Cell Enrichment Based on Physical Properties."
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SLAS ELN Reports: Master the Interviewing Continuum to Land Your Desired Position
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"Interviewing has many forms," says SLAS career consultant Dan Eustace in the SLAS Electronic Laboratory Neighborhood e-zine. Eustace recommends preparing yourself through informational, networking and mock interviews even before you land a job interview. He then outlines the numerous types of job interviews one might experience — and offers tips on how to be successful — before wrapping up with advice on post-interview techniques. More

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Buzzin' on SLAS LinkedIn
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Jump in with your thoughts to this question: Where do you think the early drug discovery process is in most need of innovation and improvement? SLAS member and LabAutopedia Editor Al Kolb started the LinkedIn discussion last week. Something on your mind? Use LinkedIn to see how your colleagues might help. More


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Call for Papers: Three new special issues of SLAS journals announced
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JALA and JBS are now accepting manuscript proposals for three new special issues: Both JBS and JALA consider previously unpublished, original research and review manuscripts from SLAS members and nonmembers. More


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Member survey sweepstakes winners announced
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Congratulations to Samila Nasrollahi of the University of Akron who was awarded the grand prize in the SLAS 2013 Membership Survey Sweepstakes. Nasrollahi's name was randomly drawn among all eligible survey respondents. In conjunction with this prize Nasrollahi receives airfare, lodging and complimentary registration to SLAS2014. Additionally, two complimentary SLAS2014 registrations and 10 American Express $50 gift cards were awarded. Thank you to everyone who shared their thoughts and opinions by completing this survey. More

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SLAS2014 Event Scheduler now includes exhibitor tutorials
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More than 40 exhibitor tutorials are now detailed in the SLAS2014 Event Scheduler to help you plan your SLAS2014 experience. Exhibitor tutorials are 45 to 90 minute deep dives into topics such as "Label-free Biochemical Assays in Drug Discovery Using Agilent's RapidFire High-Throughput Mass Spectrometry System" by Agilent Technologies on Tuesday, Jan. 21, or "High-Throughput Phenotypic Screening of 3D Cell Culture Models" by TTP Labtech on Monday, Jan. 20. More

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Biomarker discovery — the need for new generation peptideprotein microarrays
Drug Discovery World    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The progression from health to disease is marked by significant biological changes within an individual. Clinically presenting symptoms, however, can be non-specific and variable enough to hinder diagnosis, and may appear only after a disease has already become well-established and consequently more difficult to treat. More

Stay-or-stray protein implicated in spread of cancer cells
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
If it were possible to reduce the vigor with which cancer cells migrate, entering nearby blood vessels and penetrating neighboring tissues, the cells would be far less dangerous, and cancer itself far less deadly. To find ways to slow the spread of cancer, scientists have been investigating why certain cancer cells may remain homebodies, or turn into bold wanderers. More


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SlipChip counts molecules with chemistry and a cell phone
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In developing nations, rural areas, and even one's own home, limited access to expensive equipment and trained medical professionals can impede the diagnosis and treatment of disease. Many qualitative tests that provide a simple "yes" or "no" answer (like an at-home pregnancy test) have been optimized for use in these resource-limited settings. But few quantitative tests — those able to measure the precise concentration of biomolecules, not just their presence or absence — can be done outside of a laboratory or clinical setting. More

Sunlight helps turn salty water fresh
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
With energy-efficient desalination techniques, water-starved communities could produce fresh water from salty sources such as seawater and industrial wastewater. But common methods like reverse osmosis require pumping the water, which uses a substantial amount of energy. So some researchers have turned to forward osmosis, because in theory it should use less energy. Now a team has demonstrated a forward osmosis system that desalinates salty water with the help of sunlight. More

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Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG
ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Modern medicine is founded on the discovery of penicillin and subsequent small molecules that inhibit bacterial peptidoglycan and cell wall synthesis. However, the discovery of new chemically and mechanistically distinct classes of PG inhibitors has become exceedingly rare, prompting speculation that intracellular enzymes involved in PG precursor synthesis are not "druggable" targets. More

Sugary drinks tinker with vital proteins in the brain
New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Glugging lots of sugary drinks won't just make you fat, it might also lead to changes in the brain that have been linked to cancer and Alzheimer's — at least in rats. This finding comes from the first analysis of how sugary drinks affect proteins in the brain. It showed that 20 percent of the proteins produced in a brain region related to decision-making were altered in rats that drank sugary drinks compared with those given water. More



How botox binds to neurons
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Botulinum neurotoxin A, better known as botox, is a highly dangerous toxin that causes paralysis in man that may prove fatal. In cosmetic applications the paralyzing action of small doses is used in a specific manner for the temporary elimination of wrinkles and in medicine as a treatment for migraine or to correct strabismus. An international research team from the Paul Scherrer Institute, Utrecht University and the pharmaceutical company UCB has now taken an important step towards understanding the action of botulinum neurotoxin A. More

Scientists generate 'mini-kidney' structures from human stem cells
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Diseases affecting the kidneys represent a major and unsolved health issue worldwide. The kidneys rarely recover function once they are damaged by disease, highlighting the urgent need for better knowledge of kidney development and physiology. Now, a team of researchers has developed a novel platform to study kidney diseases, opening new avenues for the future application of regenerative medicine strategies to help restore kidney function. More


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Career


Robotics Support Technician
GeneDx, Inc.
US – MD – Gaithersburg

Field Application Scientist
IntelliCyt Corporation
UK – Hemel Hempstead

Laboratory Automation Specialist
Aegis Sciences Corporation
US – TN – Nashville

More jobs at SLAS Career Connections


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