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SLAS Europe Conference and Exhibition Abstracts Due Dec. 8
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SLAS invites research scientists, engineers, academics and business leaders to submit abstracts for presentation at the 2018 SLAS Europe Conference and Exhibition, June 27-29, 2018, in Brussels, Belgium. Educational tracks include:

  • Emerging Investigative Biology
  • Technology
  • Discovery

  • Presenting at 2018 SLAS Europe is a sure way to improve your research, expand your professional network and enhance your brand reputation. If you have expertise in the field of life sciences discovery and technology — or an interesting story or case study to share — please consider this opportunity to contribute to the 2018 SLAS Europe scientific program.
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    Will You Be the Third $100K SLAS Graduate Education Fellowship Grant Winner?
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    Applications are due Dec. 11 for this grant which facilitates educational opportunities for outstanding students pursuing graduate degrees related to quantitative biosciences and/or life sciences research. The first winner in 2016 was Erik M. Werner, a member of the Elliot Hui Laboratory at the University of California, Irvine. From the University of California, Berkeley, Amy Herr's student Julea Vlassakis was the 2017 winner.

    Hui notes that "the SLAS grant supports the student. It specifically gives an opportunity to research questions in which the student may have a personal interest as opposed to being driven entirely by the resources for which the lab is directly funded. The SLAS grant also gives students more access to the life sciences discovery and technology industry and to people who are conducting drug screening and automation of biological assays."
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    Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing
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    A review article in the December 2017 issue of SLAS Technology provides important information for those interested in antibiotic resistance, general microbial detection principles, in vitro diagnostics, micro- and nanotechnologies, and next generation rapid microbial testing methods.

    Authors Yiyan Li, Xing Yang and Weian Zhao of University of California, Irvine, highlight and synthesize representative emerging micro- and nanotechnologies, as well as automated systems for bacterial identification and antibiotic susceptibility testing, including both phenotypic and molecular methods and those at the point-of-care setting. Visit SLAS Technology Online to read this review for free for a limited time.
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    SLAS2018 Event Scheduler Now Includes Poster Abstracts
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    Nearly 200 posters selected by the SLAS2018 Scientific Program Committee for presentation at SLAS2018 in San Diego can now be found in the SLAS2018 Event Scheduler. Access the Scheduler, select Poster Presentations & Gallery and then Poster Abstracts to learn more about posters like "3D High-Content Screening of Liver Spheroids," "Application of Acoustic Mass Spectrometry to the Syk Kinase Assay," "Imaging-Based Cytotoxicity Assays," "Portable Biosensor for Monitoring Cortisol in Low-Volume Perspired Human Sweat" and more.

    There is still time to submit your work — the final poster abstract submission deadline is Jan. 22.
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    Dec. 12 SLAS Webinar: How AstraZeneca is Revolutionizing Sample Management with Acoustic Tube-Based Technologies
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    Learn about AstraZeneca's vision to enhance its sample management capabilities by adopting acoustic liquid handling throughout sample storage and screening preparation workflows. Kevin Cross, senior scientist, sample management at AstraZeneca, discusses the benefits of adopting the new acoustic tube technology and how AstraZeneca is approaching its integration into its sample management infrastructure. Justin Jager, product manager, lab automation at Labcyte, provides an overview of the new automated system and highlights how it addresses the needs of sample management teams at AstraZeneca.

    This SLAS Webinar, to be held live Dec. 12 and then available on demand, is open to members and non-members alike.
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    Happy Thanksgiving!
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    As family and friends in the United States gather tomorrow to celebrate Thanksgiving, SLAS is thankful for its members around the world and their commitment to life sciences discovery and technology. So, grab a turkey drumstick, watch a parade or football game, laugh and spend time with your loved ones.

    As you commemorate that first autumn feast in 1621, be sure to thank someone for what they bring to your life.
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    CRISPR-Carrying Nanoparticles Edit the Genome
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    In a new study, MIT researchers have developed nanoparticles that can deliver the CRISPR genome-editing system and specifically modify genes in mice. The team used nanoparticles to carry the CRISPR components, eliminating the need to use viruses for delivery. Using the new delivery technique, the researchers were able to cut out certain genes in about 80 percent of liver cells, the best success rate ever achieved with CRISPR in adult animals. More


    Electrochemistry Opens Up Novel Access to Important Classes of Substances
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Electrochemistry has undergone a renaissance in recent years and numerous research groups are currently working on the environmentally friendly production or conversion of molecules. However, despite the superiority of electrochemistry, its application to various molecules has been problematic. The electrolysis of highly reactive substances, for example, has so far only led to the formation of high-molecular weight products, i.e., polymers. This method of production was sometimes even used on purpose as in the examples of polythiophene and polyaniline, the latter also being known as aniline black. More




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    Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    CRISPR-Cas9 is a genome editing technology with major impact in life sciences. In this system, the endonuclease Cas9 generates double strand breaks in DNA upon RNA-guided recognition of a complementary DNA sequence, which strictly requires the presence of a protospacer adjacent motif (PAM) next to the target site. Although PAM recognition is essential for cleavage, it is unknown whether and how PAM binding activates Cas9 for DNA cleavage at spatially distant sites. Here, we find evidence of a PAM-induced allosteric mechanism revealed by microsecond molecular dynamics simulations. More


    Chemists Conquer Oxidative Dearomatization With Trio of Enzymes
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Enzymes often elicit envy from organic chemists. Highly evolved by nature, these biocatalysts can carry out reactions with a selectivity that surpasses most synthetic catalysts. Yet they act on such a narrow range of substrates that chemists haven't been able to exploit their abilities in a general way. In an effort to broaden enzymes' reach, researchers led by Alison Narayan at the University of Michigan explored how three known enzymes — called TropB, AzaH, and SorbC — carry out the same reaction. More




    Detailed View of Immune Proteins Could Lead to New Pathogen-Defense Strategies
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    Biologists have resolved the structure of a ring of proteins used by the immune system to summon support when under attack, providing new insight into potential strategies for protection from pathogens. The study, led by researchers at the Department of Energy's Lawrence Berkeley National Laboratory and at UC Berkeley, used cryo-electron microscopy to capture a high-resolution image of a protein ring called an "inflammasome" as it was bound to flagellin, a protein from the whiplike tail used by bacteria to propel themselves forward. More


    Unlike CRISPR Knockout and RNAi Knockdown, Trim-Away Depletes Proteins Straightaway
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Deprived of one of its proteins, a cell may betray the protein's function — but not always. If the cell is deprived of the protein indirectly, at the level of protein-coding DNA or RNA (that is, via CRISPR/Cas9 knockout or RNA interference [RNAi] knockdown), the cell will experience a deficit only after many hours or even days have passed. The cell may have time to develop mechanisms to compensate for the loss of a protein. And so, the cell may effectively hide the protein's function, particularly if the protein is long-lived. More


    Drug Development Could Suffer from Proposed NIH Budget Cuts
    The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    In March, President Donald Trump's administration released its proposed 2018 budget, which included a significant cut to funding for the National Institutes of Health. Now, an analysis from researchers at Washington University School of Medicine in St. Louis suggests that the reduction — which amounts to $7.2 billion, or 21 percent of the agency's bolstered 2017 budget — could hamper researchers' ability to develop novel, potentially life-saving drugs. More


    Development of New Protein May Lead to Novel Treatment Options for Cancer, Birth Defects
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Researchers have engineered an artificial protein that may block malignant properties of cancer cells as well as correct certain birth defects. The findings, which appear in the journal Proceedings of the National Academy of Sciences, may lead to identifying new molecular targets suitable for therapeutic intervention. Cells in the human body need to communicate with each other to function properly. This is accomplished by a molecular mechanism called signal transduction and its dysregulation leads to human disease. More


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