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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit November 23, 2016

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SLAS Europe Conference Brings Researchers and Funders Together
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"Translating Research Ideas into Future Therapeutics Conference," Nov. 29-30 in Leuven, Belgium, takes a head-on approach to scientific collaboration. The event brings academic scientists and innovative start-ups together with funding organizations looking for novel therapeutic innovations.

Scientists with new ideas or already established assets in the areas of small molecule, biologicals and enabling technologies have a rare opportunity to talk about progress, learn from the experiences of colleagues and potentially build new alliances and create new development partnerships. The conference takes place at the historic M Museum in the heart of the city.
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The Lab Man in SLAS ELN: The Dark Genome — Let There Be Light
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"The dark genome represents the set of genes and their corresponding proteins that remain unstudied or understudied. Given that target validation is a critical bottleneck in the discovery of new therapeutics, illumination of the dark genome could identify druggable targets relevant to diseases," says Rajarshi Guha, research scientist at the U.S. National Institutes of Health (NIH) National Center for Advancing Translational Sciences and chair of the SLAS2017 Informatics Session on Let There Be Light: Informatics Approaches to Exploring the Dark Genome.

Guha and The Lab Man review how informatics is foundational to collating multiple data sources and types, developing workflows and making that available to users ready to move advances forward, including the four researchers presenting in this session at SLAS2017.
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If You Don't Yet have an ORCID ID, Get One!
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Protect your scholarly identity by registering for an ORCID unique identifier so editors, funding agencies, publishers and institutions can reliably recognize you in the same way that ISBNs and DOIs identify books and articles.

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SLAS2017 Short Course Spotlight: Liquid Handling Essentials
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This interactive course introduces important concepts to maximize liquid handling performance and ensure reliable assay results. With a balanced mix of discussions and activities, beginning students apply key practices on live robotic systems and measure performance metrics as they move from station to station.

Instructors are Nathaniel Hentz of North Carolina State University, Dana Campbell of Artel and Lisa Knapp of Agilent Technologies. Liquid Handling Essentials is one of 21 short courses to be held at SLAS2017 and was featured in a past issue of the SLAS Electronic Laboratory Neighborhood e-zine.
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Prepare for 2017: Renew Your SLAS Membership
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To ensure uninterrupted access to all SLAS member benefits, be sure to renew your membership before Dec. 31. Benefits include subscriptions to the SLAS journals, on-demand access to webinars, event registration discounts and other year-round educational resources tailored to help you leverage the power of scientific innovation.

If you plan to attend SLAS2017, your dues must be paid to take advantage of deep members only registration discounts (up to $210 if you register by Dec. 19). For your convenience, you can include your member dues when you register for SLAS2017.
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A Thanksgiving Wish
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As family and friends in the United States gather tomorrow to celebrate Thanksgiving, we want to say THANK YOU to SLAS members around the world for their commitment to life sciences discovery and technology and loyalty to SLAS.

Enjoy a quick video and article from The History Channel and learn some interesting and yes, somewhat strange, facts about this U.S. national holiday.
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A Milestone in Small RNA Biology: piRNA Biogenesis From Start to Finish
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Organisms are in a constant battle against viruses, or transposable elements, which invade their genomes. Among their most effective weapons are silencing pathways that use small RNAs to selectively target invading nucleic acids for their destruction. The molecular understanding of these defense systems has revolutionized modern molecular biology, as they are the basis for powerful genome editing and gene silencing methods such as CRISPR/Cas9 or RNA interference. More


Cleantech Industry Ponders Trump Presidency
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
U.S. companies that make renewable chemicals, fuels and energy are bracing for policy changes under the incoming Trump administration. Although the president-elect is skeptical about climate change, trade groups say they believe the Republican leadership will support investment in cleantech R&D and manufacturing to create jobs and boost energy security. "Even if you discount climate change initiatives, there is strong support for U.S.-based energy efficiency and domestic energy production," says Paul Winters, spokesman for the Biotechnology Innovation Organization. More


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Scientists Can't Replicate Gene-Editing Method
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Researchers continue to fail in reproducing a new gene-editing technique called NgAgo, for Natronobacterium gregoryi Argonaute, an endonuclease. In a report published in Protein & Cell, scientists from the U.S. and China working independently found no evidence that NgAgo could manipulate DNA sequences. “Some of us have even sent visiting researchers to [Chunyu] Han's laboratory but they were not allowed to perform genome editing experiments involving mammalian cells when they were there," the authors wrote in their report. More


Nanoparticle Assembly of Surface-Modified Proteins
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Nature's biomaterials such as peptides and proteins represent a valuable source of highly defined macromolecules. Herein we developed a nanoparticle drug delivery system based on the assembly of surface-modified proteins that can be transferred into organic solvents and represent the structural material of the carrier system. The particles are prepared by an oil-in-water nanoemulsion technique without the need of additional denaturation or cross-linking steps for stabilization. More


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Sculpting How Chemicals Spread in Fluid Flows
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Art was created with proportions in mind so spaces would make mathematical sense. Now two mathematicians from the University of North Carolina at Chapel Hill and their team have created art of their own: a method that precisely sculpts how fluids spread chemicals as they travel to hit their target. The work has profound implications in fields such as medicine, chemistry and environmental management, where having the ability to precisely control how drugs, chemicals and pollutants approach their destination is potentially critical. More


Gene Editing Works in Nondividing Cells, Ameliorates Blindness
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A proof-of-concept study has shown that a new genome-editing approach not only works in nondividing cells, it also allows for the efficient and targeted insertion of genes when it is used in animal models. The new approach is called HITI, for homology-independent targeted integration. HITI looks particularly promising because it opens a largely unused pathway to the targeted genetic revision of live adult organisms. More


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Only Half of a Chromosome is DNA, 3-D Imaging Shows
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
DNA makes up only half of the material inside chromosomes — far less than was previously thought — a study has revealed. Up to 47 percent of their structure is a mysterious sheath that surrounds the genetic material, researchers say. While the precise function of this sheath is unknown, researchers suggest it may keep chromosomes isolated from one another during the key process of cell division. Researchers say this so-called chromosome periphery could help to prevent errors from occurring when cells divide. More


'Beautiful Accident' Leads to Advances in High Pressure Materials Synthesis
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Unexpected results from a neutron scattering experiment at the Department of Energy's Oak Ridge National Laboratory could open a new pathway for the synthesis of novel materials and also help explain the formation of complex organic structures observed in interstellar space. In a paper published in the journal Angewandte Chemie International Edition, the multi-institutional team of researchers discuss their discovery of using high pressures — rather than high temperatures — to initiate chemical reactions. More




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Medical Science & Computing
US – MD – Gaithersburg

Scientific Leader, Platform Biology Automation
GSK
US – PA

Postdoctoral Research Fellow – Cell Biology/Mechanotransduction
NIH National Institute on Deafness and Other Communication Disorders
US – MD – Bethesda

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