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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit November 25, 2015

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SLAS ELN Reports: Functional Metagenomics for Drug Discovery
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According to Louis Cohen, M.D., a researcher at The Rockefeller University, NYC, and an SLAS2016 podium presenter, "metagenomics is the answer to tried-and-true, culture-based small molecule discovery approaches." Functional metagenomics enables researchers to investigate the proteins produced by bacteria without first having to understand the microbial community's underlying gene sequence or the structure of the protein of interest.

"We can study any bacteria from which we can extract high molecular weight DNA," he says. Learn more about his discoveries in the SLAS Electronic Laboratory Neighborhood e-zine now and then at SLAS2016 on Tuesday, Jan. 26.
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New in JALA Online: An Artificial Chromosome from the U.S. Dept. of Agriculture (USDA)
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"Process for Assembly and Transformation into Saccharomyces cerevisiae of a Synthetic Yeast Artificial Chromosome Containing a Multigene Cassette to Express Enzymes That Enhance Xylose Utilization Designed for an Automated Platform" demonstrates the feasibility of a yeast artificial chromosome containing a multi-gene cassette as a stable protein expression system in yeast.

Authored by a team of researchers led by Stephen R. Hughes, Ph.D., of the USDA, Agricultural Research Service, National Center for Agricultural Utilization Research, Renewable Product Technology Research Unit (Peoria, IL), the report reflects the culmination of 12 years of research toward improving energy security and achieving sustainable biofuel production. The result is a one-step automated platform for introduction of multiple genes to enhance biomass utilization by industrial microbial biocatalysts. SLAS Laboratory Automation Section members and JALA subscribers can view this manuscript and more from the December issue at JALA Online.
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SLAS2016 Short Courses: Deep Dives into Focused Topics
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Check the list of 19 half-, one- and two-day SLAS2016 Short Courses scheduled for SLAS2016 in San Diego. The SLAS2016 Short Course Planning Committee — Chair Sue Holland-Crimmin, GSK; Andrew Napper, Nemours Center for Childhood Cancer Research; Burkhard Schaefer, BSSN Software; and Martin Valler, Boehringer Ingelheim Pharma — reviewed SLAS2015 participant evaluations and re-engineered course offerings to best reflect the needs of the community. New topics for SLAS2016:

Saturday, Jan. 23
  • Multiparametric Analysis of Scientific Image Data
Sunday, Jan. 24
  • High-Content Screening: An Introduction to Instrumentation, Assay Development, Screening, Image and Data Analysis
  • Study Design and Statistical Analysis for High-Throughput Screening Experiments
  • Lab-on-a-chip: Case Studies in Diagnostics and Screening
  • Screening Strategies for Drug Discovery: Matching Tools with Solutions
  • Gene Editing for Drug Discovery
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December JBS: Drug Discovery of Therapies for DMD
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A new review published in the December 2015 issue of the Journal of Biomolecular Screening (JBS) details state-of-the-art drug discovery research to identify therapies for Duchenne Muscular Dystrophy (DMD). DMD is a devastating, incurable, genetic muscle-wasting disorder affecting one of every 3500-5000 males born.

The review is authored by Yuval Blat, Ph.D., formerly the director of biology at Armgo Pharma, a company developing drugs for DMD; and Shachar Blat of the Department of Neuroscience, University of Pittsburgh. SLAS Biomolecular Sciences Section members and JBS subscribers can view the issue online now.
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Job Seekers and Employers Connect via SLAS Career Connections
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Visit this targeted employment exchange regularly to keep up to date with new opportunities and talent. Job seekers can post resumes and browse job openings for free. Employers can find prospective employees by reviewing posted resumes for free and attract interested applicants by posting job openings for a fee (SLAS Corporate Members receive a 50% discount).

Attending SLAS2016? Take advantage of the expanded Career Connections services available in the SLAS Member Center.
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Attend the 2016 ISBER Annual Meeting
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This SLAS strategic alliance partner invites SLAS members to its 2016 Annual Meeting, Bridging the Canyon — Breaking Down Walls: Unifying Biobanking Communities to Secure our Sustainability, April 5-8 in Berlin, Germany. The 2016 International Society for Biological and Environmental Repositories Annual Meeting & Exhibits features multiple plenary sessions, educational and corporate workshops, contributed paper presentations, poster sessions and working group discussions.

Vendors from around the world demonstrate the latest products, services and technology in the field of repository and specimen collection. ISBER welcomes scientific abstract submissions by Dec. 4, 2015 of significant or novel scientific importance related to the use of environmental and biological repositories. Take advantage of the early-bird registration rate by Feb. 8, 2016, and save $200 or more on registration.
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AstraZeneca, Sanofi Agree to Share Proprietary Compounds
The Wall Street Journal    Share    Share on FacebookTwitterShare on LinkedinE-mail article
AstraZeneca PLC and Sanofi SA have agreed to share thousands of their proprietary chemical compounds with each other, an unusual deal that shows the creative lengths to which pharmaceutical companies will go to pursue new drugs. The deal involves each company giving the other free access to 210,000 usually closely guarded compounds. Each company can develop any of the shared compounds without any financial obligation to the other. More


Ground-Breaking Research Could Challenge Underlying Principles of Physics
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An international team of physicists has published ground-breaking research on the decay of subatomic particles called kaons — which could change how scientists understand the formation of the universe. Professor Christopher Sachrajda, from the Southampton Theory Astrophysics and Gravity Research Centre at the University of Southampton, has helped to devise the first calculation of how the behaviour of kaons differs when matter is swapped out for antimatter, known as direct "CP" symmetry violation. More


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Conformational Switching by Vibrational Excitation of a Remote NH Bond
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Here we describe an unprecedented reversible interconversion between two conformational states, accomplished by selective vibrational excitation of a bond remotely located in relation to the isomerizing fragment. In contrast to previous studies reporting conformational changes via vibrational excitation of a nearby OH group, in this study the transformations were successfully achieved by excitation of a distant NH stretching coordinate. More


Engineers Create New Technology for Understanding Cancer Growth
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A team of University of Toronto engineers is unrolling the mysteries of cancer — literally. They have developed a way to grow cancer cells in the form of a rolled-up sheet that mimics the 3-D environment of a tumor, yet can also be taken apart in seconds. The platform, described in a new Nature Materials paper, offers a way to speed up the development of new drugs and therapies and ask new questions about how cancer cells behave. More


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Largest Cancer Genome Datasets Now Available on the Cloud
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Two of the world's largest cancer genome datasets are now available to researchers for free, Amazon Web Services announced. The datasets, The Cancer Genome Atlas and the International Genome Consortium PanCancer will be available on Amazon S3 for credentialed researchers. TCGA includes raw and processed genomic, transcriptomic, and epigenomic data from thousands of cancer patients. The ICGC dataset includes over 2,400 consistently analyzed genomes relating to over 1,100 unique ICGC donors. More


Denisovan DNA Reveals Human Roots
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Researchers have learned more about an extinct member of the human family tree by sequencing mitochondrial and nuclear DNA from 50,000-year-old molars found in a Siberian cave. The teeth belonged to Denisovans, an extinct hominin species that was first discovered in the cave in 2008, and the genome sequences suggest that the species lived alongside Homo sapiens as well as Neanderthals. The findings were published in PNAS by a team led by the Max Planck Institute for Evolutionary Anthropology's Svante Pääbo. More




Electric Fields Remove Nanoparticles From Blood With Ease
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Engineers at the University of California, San Diego developed a new technology that uses an oscillating electric field to easily and quickly isolate drug-delivery nanoparticles from blood. The technology could serve as a general tool to separate and recover nanoparticles from other complex fluids for medical, environmental, and industrial applications. More


Microbial Sex Rapidly Disseminates Ecologically Important Genes
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Horizontal gene transfer, the scientific moniker for bacterial sex, is a fundamental part of microbial evolution, as it allows key genetic loci, such as antibiotic resistance, to spread through diverse microbial communities. However, since the event is relatively infrequent, scientists have often wondered why gene transfer events have been able to exert such strong effects. More


Polymers Makers Plunge Into 3-D Printing
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For years, three-dimensional printing companies perked along on their own, too small to attract much attention from the big chemical makers whose polymers run through their machines. But that is changing as two large firms — BASF and DSM — unveil initiatives to make new and better materials for the nascent field. The announcements were made at FormNext, a trade show held in Frankfurt. The exhibition featured 233 exhibitors. More


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Career


QA Manager
First Light Biosciences, Inc.
US – MA – Bedford

Director Research & Development
Pacific Biomarkers
US – WA – Seattle

Lab Head/Investigator, Liver Biology Research
Novartis Pharma AG
Europe – Switzerland – Basel

More jobs at SLAS Career Connections


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