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The SLAS Headquarters will be closed Thursday, November 26 and Friday, November 27 in observation of the U.S. Thanksgiving Day holiday. But you can take advantage of SLAS resources 24/7/365 including APPLIED elearning or CONNECTED community networking.
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.SLAS NEWS
December's SLAS Technology Features Cover Article, 'Advances in Technology to Address COVID-19'
SLAS
Like December’s SLAS Discovery, next month’s issue of SLAS Technology is also a special issue focused on technological innovations being developed to address the COVID-19 pandemic. This collection features the cover article “Advances in Technology to Address COVID-19” by Editors Edward Kai-Hua Chow, Ph.D., (National University of Singapore), Pak Kin Wong, Ph.D., (The Pennsylvania State University, University Park, PA, USA) and Xianting Ding, Ph.D., (Shanghai Jiao Tong University, Shanghai, China) and also includes seven research articles available via SAGE Open Access. Listen to the accompanying SLAS Technology Authors Talk Tech podcast and view the on-demand issue preview webinar to get a behind-the-scenes look at the research contained within the issue.
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The Thermo Scientific™ Orbitor™ RS2 microplate mover is a collaborative bench-top mover that provides unbeatable reliability and improved process efficiency. It’s innovative bi-directional telescoping arm coupled with it’s expansive 360° workspace provide exceptional reach and precision, making the Orbitor RS2 your trusted laboratory productivity partner.
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SLAS Announces New Scientific Director Marshall Brennan, Ph.D.
SLAS
SLAS is excited to welcome Marshall Brennan, Ph.D., as our new Scientific Director. Brennan is the former Senior Product Manager of New Product Innovation at the American Chemical Society and was the founder of ChemRxiv, a preprint repository for chemistry. As Scientific Director, Brennan will provide strategic leadership for knowledge content and delivery of topics relevant to the Society and will have broad responsibility for associated programs and services for the SLAS journals, and multi-channel educational programming and content.
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SLAS New Product Award Applications Due Monday, December 14
SLAS
Don’t miss the opportunity to get your product in front of a large audience of global purchasing influencers and compete for a coveted New Product Award during SLAS2021 Digital. Virtual promotion includes additional publicity and a New Product icon on the event platform providing extra visibility to the world's leading scientists, researchers, engineers, academics and business leaders who will visit the virtual Exhibition on their quest to learn more about cutting-edge products and services. The deadline to submit a New Product Award application is Monday, December 14.
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Technology Providers: Secure Your Spot at SLAS2021 Digital
SLAS
A variety of highly engaging sponsor and exhibitor opportunities are still available during SLAS2021 Digital but are moving quickly. Do not miss the chance to get in front of a focused group of global scientists, researchers, academics and tech professionals looking for their next innovative go-to product or service.
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Less Than Two Weeks Until the SLAS2021 Digital Early Bird Registration Deadline
SLAS
There’s no harm in registering early for a virtual event and this year we’re making early registration even more rewarding. Reserve a spot for SLAS2021 Digital by Friday, December 4 and receive a swag bag filled with a wine/beverage tumbler, SLAS pop socket, SLAS notebook and pen set, a fun science-y T-shirt and an entry into a drawing for a FREE trip to the SLAS Europe 2021 Conference and Exhibition in Vienna, June 22-25, 2021. Remember, registration for SLAS2021 is FREE for SLAS Members and students and just $249 for nonmembers.
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Introducing the BioXp™ 3250 system, a fully automated synthetic biology workstation. It dramatically reduces the timelines for identifying antibody and vaccine candidates from weeks to days by assembling DNA clones, libraries, and gene fragments — as long as 7,000 base pairs — in a single overnight run.
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Join SLAS and One Nucleus for Part Three of Turn Your Lab Automation Plans into Action Webinar Series
SLAS
The next joint SLAS and One Nucleus webinar, Swimming in Data: How to Generate Useful Returns, (Wednesday, December 2, 10:00 a.m. CST) will focus on how labs can more efficiently generate useful returns on large quantities of data through the use of AI and machine learning tools. This live webinar event will also discuss how governance plays a key role in data harvesting and what initiatives are being established for large scale data sharing. Did you miss parts one and two? They are now available on demand within SLAS APPLIED.
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A Natural Aptitude
SLAS
Rising SLAS Board Member and Manchester U fanatic Jonathan O'Connell is passionate about the future of SLAS. On this week’s episode of the New Matter podcast he discusses his career path and how his current company, Valo Health, is coming into its own within the AI in drug discovery space.
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Aurora is 100% focused on making the highest quality, highest performing Microplates available. We use the best materials, the cleanest and most precise molding operations for our Microplates. We believe that the best Microplates should be an invisible carrier for your work - not a contributor to variability in your data.
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.HEADLINES
A Polymer with Mechanochemically Active Hidden Length
Journal of the American Chemical Society
Incorporating hidden length into polymer chains can improve their mechanical properties, because release of the hidden length under mechanical loads enables localized strain relief without chain fracture. To date, the design of hidden length has focused primarily on the choice of the sacrificial bonds holding the hidden length together. Here researchers demonstrate the advantages of adding mechanochemical reactivity to hidden length itself, using a new mechanophore that integrates (Z)-2,3-diphenylcyclobutene-1,4-dicarboxylate, with hitherto unknown mechanochemistry, into macrocyclic cinnamate dimers.
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Structure of SARS-CoV-2 Envelope Protein Solved by NMR
Chemical & Engineering News
At just 75 amino acids long, the envelope protein is the smallest of the four structural proteins that make up the SARS-CoV-2 viral particle and is essential for the virus to infect cells. Data from other coronaviruses led researchers to assume that groups of five E proteins formed a pore spanning the virus’s lipid bilayer membrane. But direct evidence did not exist, as structural characterization of membrane-spanning proteins is tricky with the most commonly used techniques—X-ray crystallography and cryo-electron microscopy.
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CRISPR Technique Effectively Destroys Metastatic Cancer Cells in Living Animal
Genetic Engineering & Biotechnology News
Scientists at Tel Aviv University report that the CRISPR/Cas9 system is effective in treating metastatic cancers, which they say marks a significant step on the way to finding a cure for cancer. The researchers developed a lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The CRISPR-LNPs system carries a messenger RNA which encodes for the CRISPR enzyme Cas9 that acts as molecular scissors that cut the cells’ DNA.
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Assay for Sickle Cell Anemia Is Repurposed to Diagnose COVID-19
The Scientist
In 1965, the famous Indian filmmaker Satyajit Ray created a beloved fictional detective named Feluda. In a series of short stories, the astute gumshoe tracks a vandal trying to destroy the ancient temples of India, busts a counterfeit medicine racket in Kathmandu, and cleans Bombay smugglers’ clocks. Inspired by the great analytical skills of the detective, researchers at the Delhi-based Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology have given their new CRISPR-based diagnostic for COVID-19 the affectionate nickname of Feluda (short for FnCas9 Editor Linked Uniform Detection Assay).
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High-Res 3D Images Could Lead to Better Chromosome Models
Lab Manager
In high school textbooks, human chromosomes are pictured as wonky Xs like two hotdogs jammed together. But those images are far from accurate. "For 90 percent of the time," said Jun-Han Su of Harvard University, "chromosomes don't exist like that."
Last year, before Su graduated with his PhD, he and three current PhD candidates in the Graduate School of Arts and Sciences — Pu Zheng, Seon Kinrot, and Bogdan Bintu — captured high-resolution 3D images of human chromosomes, the complex houses for our DNA.
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Supramolecular Chemistry: Self-Constructed Folded Macrocycles With Low Symmetry
Science Daily
Molecules that are made up of multiple repeating subunits, known as monomers, which may vary or not in their chemical structure, are classified as macromolecules or polymers. Examples exist in nature, including proteins and nucleic acids, which are at the heart of all biological systems. Proteins not only form the basis of structural elements in cells, they also serve as enzymes — which catalyze essentially all of the myriad of chemical transformations that take place in living systems.
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Turn up the volume on your spheroid production with Corning ® Elplasia ® plates, which feature microcavity technology that simplify high volume spheroid production to deliver:
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Tailored laboratory automation solutions with robotics, incubators, and software The research environment is constantly changing and today’s scientists require simplified remote access and enhanced laboratory automation. Increased productivity, reduced costs, and consistent performance are all available when combining the ImageXpress® Pico Automated Cell Imaging System with the S-LAB™ plate handler from PAA, and the SCILA incubator from Inheco.
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After More Than a Decade, ChIP-Seq May Be Quantitative After All
Phys.org
For more than a decade, scientists studying epigenetics have used a powerful method called ChIP-seq to map changes in proteins and other critical regulatory factors across the genome. While ChIP-seq provides invaluable insights into the underpinnings of health and disease, it also faces a frustrating challenge: its results are often viewed as qualitative rather than quantitative, making interpretation difficult.
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Another COVID-19 Vaccine Success? Candidate May Prevent Further Coronavirus Transmission, Too
Science Magazine
A third COVID-19 vaccine candidate has convincing evidence that it works, and it may be easier to distribute and cheaper than the two other vaccines already shown to protect people. Developed by the company AstraZeneca in partnership with the University of Oxford, the vaccine had an average efficacy of 70% in preventing the disease, the developers announce today in press releases. In one dosing scheme, its efficacy was 90%, according to results from the interim analysis of clinical trial data.
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Fluorescent 3CLpro/Mpro Inhibitor AssaySARS-CoV-2 Pseudovirus Fluorescent ReporterFluorescent BacMam Host Factors
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.CAREER CONNECTIONS
Job Seekers: Post your résumé and sign up for new job alerts by keyword.
Employers: Search résumés, post an open position, internship or post-doc opportunity.
SLAS Premier and Corporate Members get a discount on all new job postings.
Bioinformatics Scientist
Harvard University Faculty of Arts and Sciences
US – MA – Cambridge
Research Associate
East Carolina University
US – NC – Greenville
Assistant Project Scientist in Biochemistry
University of California, Riverside
US – CA – Riverside
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