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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit November 26, 2014

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As the United States celebrates Thanksgiving tomorrow, SLAS extends its thanks to you — members of the worldwide laboratory science and technology community. We appreciate the good work you do and your support of SLAS.


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New Issue of JALA Reviews Nanomedicine for Global Health
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The JALA editor-in-chief, deputy editor-in-chief and their teams explore the evolving use of nanotechnology in medical studies.

The JALA December issue also features seven original research manuscripts including "Dynamically Optimizing Experiment Schedules of a Laboratory Robot System with Simulated Annealing," "Antibody-Conjugated Gold Nanoparticle-Based Immunosensor for Ultra-Sensitive Detection of Troponin-T" and "Laboratory Automation in a Functional Programming Language."

Technology briefs on microfluidic molecular assay platforms at single-cell resolution and a novel robotic platform for parallelized cultivation and monitoring in microwell plates round out the issue now available online to SLAS Laboratory Automation Section members and JALA subscribers.
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Congratulations to SLAS Young Scientist Delegate from Shanghai
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Kyungmoo Yea of the Shanghai Institute for Advanced Immunological Studies, ShanghaiTech University was named an SLAS Young Scientist Delegate last week at BioForum 2014, an SLAS collaboration with the Shanghai Institute for Advanced Immunological Studies of ShanghaiTech University.

The student's winning poster was titled "An Adiponectin Receptor Agonist Antibody Induces CD34+ Bone Marrow Cells to Differentiate into Brown Fat."

Yea works in the Richard A. Lerner group; Lerner is the former president of The Scripps Research Institute. In conjunction with this distinction, Yea receives a $500 cash prize, roundtrip airfare, hotel accommodations and full conference registration for SLAS2015, Feb. 7-11, 2015, Washington, DC.
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SLAS ELN Reports: Inspiration, Discovery, Excitement — JALA & JBS Art of Science Contest
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"We all understand how inspiring it is for younger generations to look at cool science images, but there is definitely more to it than that," says Tomasz Koprowski, 2014 JALA & JBS Art of Science Contest grand prize winner from the Institute for Chemical and Bioengineering in Zurich, Switzerland. "It also gives us a boost to create and invent. All people get influenced by beauty, even the scientists."

Learn more about Koprowski and other 2014 contest winners in the SLAS Electronic Laboratory Neighborhood e-zine. Then submit your best scientific image to the 2015 JALA & JBS Art of Science Contest by Dec. 24, 2014.
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    FREE at JBS Online: Quantification of Histone H3 Lys27 Trimethylation (H3K27me3) by High-Throughput Microscopy Enables Cellular Large-Scale Screening for Small-Molecule EZH2 Inhibitors
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    A team of researchers from Bayer Pharma in Germany describes an approach that quantifies changes in global levels of histone modification marks using HCA.

    The approach is validated in different cell lines by using small interfering RNA and SMOL inhibitors. With automation and miniaturization, the authors demonstrate its utility in conducting phenotypic HTS campaigns and assessing structure-activity relationships (SAR).

    This assay enables screening of SMOL EZH2 inhibitors and can advance the mechanistic understanding of H3K27me3 suppression. This original research is fully and freely available at JBS Online ahead-of-print.
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    LabAutopedia Video of the Month: I Love to Be a Scientist
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    The SLAS scientific wiki's video of the month features Stefan W. Hell, co-winner of The Nobel Prize in Chemistry 2014 for the development of super-resolved fluorescence microscopy.

    "I love to be a scientist. I've always enjoyed being curious. I've always enjoyed doing challenging things and also challenging common wisdom. So, I think that's something a scientist can do because a scientist works at a border, at the edge of science, at the edge of knowledge, and so there's a lot of fun reaching out and thinking about things that other people don't think about."
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    Donald Ingber: My Favorite Publication is the One that People Have Never Read
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    The SLAS2015 keynote speaker and founding director of the Wyss Institute for Biologically Inspired Engineering answered this way when asked to identify his favorite published work in a recent interview in Nanomedicine.

    He chose a book chapter, written in 1985, that "essentially lays out all of my strange ideas relating to tensegrity, mechanobiology, development and cancer that I pursued for the rest of my career, and eventually confirmed experimentally."

    Ingber presents "Human Organs-on-Chips as Replacements for Animal Testing" at SLAS2015 during the opening keynote Monday, Feb. 8, 2015 in Washington, DC.
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    Drug Spending to Reach $1.3 Trillion by 2018, Report Forecasts
    Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Spending on medicines will rise 30% over the next five years, ballooning to $1.3 trillion in 2018, as about 200 new drugs come to market, patent-cliff expirations ebb, and demand grows worldwide—especially for newer specialty treatments in cancer and hepatitis C, a report by the IMS Institute for Healthcare Informatics has concluded. "Global Outlook for Medicines Through 2018" predicted a $70 billion spending increase this year, with worldwide spending set to crack the trillion-dollar mark as a result. More

    A Green Transformation for Pharmaceuticals
    Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    A more sustainable approach to a bond-forming reaction extensively used in the pharmaceutical and fine chemical industries has been developed by an international research team led by A*STAR. The team used the solvent-free, catalytic reaction to produce high yields of a wide range of amides, including the antidepressant moclobemide and other drug-like molecules. More



    Foundation Sells $3.3 Billion in Vertex Drug Royalties
    Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The Cystic Fibrosis Foundation says it has sold royalty rights worth $3.3 billion for innovative drugs it helped develop with Vertex Pharmaceuticals Incorporated. The drug rights were acquired by Royalty Pharma, which owns royalty rights to 40 pharmaceutical medicines. The foundation plans to use the proceeds to expand research into therapies for cystic fibrosis, a deadly inherited illness that causes sticky mucus buildup in the lungs and other organs. More

    Molecular Recognition of Brucella A and M Antigens Dissected by Synthetic Oligosaccharide Glycoconjugates Leads to a Disaccharide Diagnostic for Brucellosis
    Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The cell wall O-polysaccharides of pathogenic Brucella species are homopolymers of the rare sugar 4,6-dideoxy-4-formamido-α-⫐-mannopyranose. Despite the apparent simplicity of the polysaccharide it appears to be a "block copolymer" composed of A and M polysaccharide sequences expressed as a single molecule. More


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    Google's Nanoparticle Diagnostic Vision
    Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    When the Internet impresarios at Google speak, the world listens. So the usual hoopla ensued when Google announced its latest ambition: to develop nanoparticle diagnostics paired with a wearable detector. One interview even brought up the tricorder, the fictional diagnostic device from "Star Trek." Diagnostic development doesn’t happen at warp speed. More

    Quantum Mechanical Calculations Reveal the Hidden States of Enzyme Active Sites
    Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Enzymes carry out fundamental biological processes such as photosynthesis, nitrogen fixation and respiration, with the help of clusters of metal atoms as "active" sites. But scientists lack basic information about their function because the states thought to be critical to their chemical abilities cannot be experimentally observed. Now, researchers have reported the first direct observation of the electronic states of iron-sulfur clusters, common to many enzyme active sites. More

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    A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis
    ACS Chemical Biology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    The Mycobacterium tuberculosis (Mtb) igr operon plays an essential role in Mtb cholesterol metabolism, which is critical for pathogenesis during the latent stage of Mtb infection. Here we report the first structure of a heterotetrameric MaoC-like enoyl-CoA hydratase, ChsH1-ChsH2, which is encoded by two adjacent genes from the igr operon. More

    'Good Viruses' Defend Gut When Bacteria are Wiped Out
    New Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
    Viruses have a bad rep, but some may help protect the body from illness, much like the "good bacteria" that dwell in our gut. Our guts are home to a whole host of bugs, referred to collectively as our microbiome. This includes bacteria that are known to be beneficial to our health; helping to digest our food, building up our immune system and protecting us from disease. Our microbiomes also include lots of viruses, but their role in gut health has not been widely studied. More

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    Vertex Pharmaceuticals
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