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FREE at JBS Online: Quantification of Histone H3 Lys27 Trimethylation (H3K27me3) by High-Throughput Microscopy Enables Cellular Large-Scale Screening for Small-Molecule EZH2 Inhibitors
A team of researchers from Bayer Pharma in Germany describes an approach that quantifies changes in global levels of histone modification marks using HCA.
The approach is validated in different cell lines by using small interfering RNA and SMOL inhibitors. With automation and miniaturization, the authors demonstrate its utility in conducting phenotypic HTS campaigns and assessing structure-activity relationships (SAR).
This assay enables screening of SMOL EZH2 inhibitors and can advance the mechanistic understanding of H3K27me3 suppression. This original research is fully and freely available at JBS Online ahead-of-print. More
LabAutopedia Video of the Month: I Love to Be a Scientist
The SLAS scientific wiki's video of the month features Stefan W. Hell, co-winner of The Nobel Prize in Chemistry 2014 for the development of super-resolved fluorescence microscopy.
"I love to be a scientist. I've always enjoyed being curious. I've always enjoyed doing challenging things and also challenging common wisdom. So, I think that's something a scientist can do because a scientist works at a border, at the edge of science, at the edge of knowledge, and so there's a lot of fun reaching out and thinking about things that other people don't think about." More
Donald Ingber: My Favorite Publication is the One that People Have Never Read
The SLAS2015 keynote speaker and founding director of the Wyss Institute for Biologically Inspired Engineering answered this way when asked to identify his favorite published work in a recent interview in Nanomedicine.
He chose a book chapter, written in 1985, that "essentially lays out all of my strange ideas relating to tensegrity, mechanobiology, development and cancer that I pursued for the rest of my career, and eventually confirmed experimentally."
Ingber presents "Human Organs-on-Chips as Replacements for Animal Testing" at SLAS2015 during the opening keynote Monday, Feb. 8, 2015 in Washington, DC. More
Drug Spending to Reach $1.3 Trillion by 2018, Report Forecasts
Genetic Engineering & Biotechnology News Share
Spending on medicines will rise 30% over the next five years, ballooning to $1.3 trillion in 2018, as about 200 new drugs come to market, patent-cliff expirations ebb, and demand grows worldwide—especially for newer specialty treatments in cancer and hepatitis C, a report by the IMS Institute for Healthcare Informatics has concluded. "Global Outlook for Medicines Through 2018" predicted a $70 billion spending increase this year, with worldwide spending set to crack the trillion-dollar mark as a result. More
A Green Transformation for Pharmaceuticals
A more sustainable approach to a bond-forming reaction extensively used in the pharmaceutical and fine chemical industries has been developed by an international research team led by A*STAR. The team used the solvent-free, catalytic reaction to produce high yields of a wide range of amides, including the antidepressant moclobemide and other drug-like molecules. More
Foundation Sells $3.3 Billion in Vertex Drug Royalties
Bioscience Technology Share
The Cystic Fibrosis Foundation says it has sold royalty rights worth $3.3 billion for innovative drugs it helped develop with Vertex Pharmaceuticals Incorporated. The drug rights were acquired by Royalty Pharma, which owns royalty rights to 40 pharmaceutical medicines. The foundation plans to use the proceeds to expand research into therapies for cystic fibrosis, a deadly inherited illness that causes sticky mucus buildup in the lungs and other organs. More
Molecular Recognition of Brucella A and M Antigens Dissected by Synthetic Oligosaccharide Glycoconjugates Leads to a Disaccharide Diagnostic for Brucellosis
Journal of the American Chemical Society Share
The cell wall O-polysaccharides of pathogenic Brucella species are homopolymers of the rare sugar 4,6-dideoxy-4-formamido-α-⫐-mannopyranose. Despite the apparent simplicity of the polysaccharide it appears to be a "block copolymer" composed of A and M polysaccharide sequences expressed as a single molecule. More
Google's Nanoparticle Diagnostic Vision
Chemical & Engineering News Share
When the Internet impresarios at Google speak, the world listens. So the usual hoopla ensued when Google announced its latest ambition: to develop nanoparticle diagnostics paired with a wearable detector. One interview even brought up the tricorder, the fictional diagnostic device from "Star Trek." Diagnostic development doesn’t happen at warp speed. More
Quantum Mechanical Calculations Reveal the Hidden States of Enzyme Active Sites
Science Daily Share
Enzymes carry out fundamental biological processes such as photosynthesis, nitrogen fixation and respiration, with the help of clusters of metal atoms as "active" sites. But scientists lack basic information about their function because the states thought to be critical to their chemical abilities cannot be experimentally observed. Now, researchers have reported the first direct observation of the electronic states of iron-sulfur clusters, common to many enzyme active sites. More
A Distinct MaoC-like Enoyl-CoA Hydratase Architecture Mediates Cholesterol Catabolism in Mycobacterium tuberculosis
ACS Chemical Biology Share
The Mycobacterium tuberculosis (Mtb) igr operon plays an essential role in Mtb cholesterol metabolism, which is critical for pathogenesis during the latent stage of Mtb infection. Here we report the first structure of a heterotetrameric MaoC-like enoyl-CoA hydratase, ChsH1-ChsH2, which is encoded by two adjacent genes from the igr operon. More
'Good Viruses' Defend Gut When Bacteria are Wiped Out
New Scientist Share
Viruses have a bad rep, but some may help protect the body from illness, much like the "good bacteria" that dwell in our gut. Our guts are home to a whole host of bugs, referred to collectively as our microbiome. This includes bacteria that are known to be beneficial to our health; helping to digest our food, building up our immune system and protecting us from disease. Our microbiomes also include lots of viruses, but their role in gut health has not been widely studied. More
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