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  Mobile version   RSS   Subscribe   Unsubscribe    SLAS2012   Moving? New job? Let SLAS know.    Nov. 30, 2011



SLAS elections end this Friday
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The 2012 SLAS Board of Directors election ends this Friday, Dec. 2. All dues-paid SLAS members received a ballot with voting instructions via e-mail on Nov. 15. Learn about the eight candidates vying for three open positions, and then make your voice heard. Questions? Contact Mary Geismann. More


Enter the JALA & JBS Art of Science Contest before this Friday
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Share your interesting and original scientific images with SLAS by Dec. 2 for a chance to win an iPad2 or one of ten $50 gift certificates. More

Small automated pipettors perform big
SOLO & SOLOPlus Automated Pipettors are the perfect choice for automating repetitive and time consuming applications. Available in single channel, 8-channel and 12- channel configurations the SOLO handles serial dilutions, kinase assays and next-gen sequencing prep with ease. Multiple deck configurations, accessories and robotics are available. See more at Email

SLAS2012 kicks off with important short course programs
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Add a short course to your SLAS2012 plans. One and two-day options are offered on Saturday and Sunday, Feb. 4 and 5, on a wide array of scientific topics, including liquid handling, next generation sequencing, sample management and automated assays for drug discovery. Discounts available. More


The Great Stagnation: Newest LabAutopedia book
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The Great Stagnation: How America Ate All the Low-Hanging Fruit of Modern History, Got Sick, and Will (Eventually) Feel Better is this month's featured book. SLAS shares interesting titles in the SLAS Electronic Laboratory Neighborhood e-zine and in the LabAutopedia archive. More

Multispan: Source for High Quality GPCR Assays

We offer the industry’s largest human and ortholog GPCR stable cell line collection and hundreds of customizable options for your functional and binding screening and profiling needs, with the highest quality and fastest turnaround. More>> Email:

Have you reserved your hotel room for SLAS2012?
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Reserve your room at the Hilton San Diego Bayfront this week and stay in the center of SLAS2012 activities. Rooms are filling fast at special SLAS2012 discounted rates, which include free in-room Internet and fitness center access. More

Interrogating Chemical Space now available On-Demand
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The recent four-part SLAS Virtual Course, "Interrogating Chemical Space — Rules, Filters, Fragment-Based Screening and More," can be purchased for streaming or on CD. Course speakers Chris Lipinski, Mike Hann, Daniel Erlanson and Daniel Wyss discussed the course topic in the SLAS Electronic Laboratory Neighborhood article, Tackling Chemical Space: All Hands on Deck. More
Microfluidic-free Kinetic Characterization Label-Free Assays
Do less and get more from your kinetic assays

• Screen up to 1000 kinetic interactions in 6 hours
• Analyze crude samples microfluidics-free in 96 and 384-well plates
• Get ka, kd, KD data in minutes, not hours or days
• Acquire real-time, SPR-quality kinetic data without the cost

Octet Systems with Dip and Read assays. Easy, worry-free kinetics.

Contact us to learn more.
Introducing the BIND® SCANNER from SRU Biosystems
SRU Biosystems has introduced the first and only high resolution, optical, label-free plate reader. Capable of measuring functional responses in individual cells, the SCANNER represents a new paradigm in drug discovery enabling the use of primary cells earlier in drug discovery process. Contact us to learn more.
Large Volume Transfection for Cell-Based Assays from MaxCyte
The MaxCyte® STX™ Scalable Transfection System enables rapid, large volume transfection of cell lines, primary cells, and other difficult-to-transfect cells for cell-based screening assays. Transfect up to 1E10 cells in less than 30 minutes. The STX produces quality transiently transfected cells for GPCR, Ion Channel and Kinase Assays… and more!


Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase
Journal of Medicinal Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds that display good pharmacological profiles with significantly improved oral bioavailability. More


Ab initio study of key branching reactions in biodiesel and Fischer-Tropsch fuels
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Many biologically and Fischer–Tropsch synthesized fuels contain branched alkanes which, during their combustion and atmospheric oxidation mechanism, produce methylalkyl radicals. As a result, an accurate description of the chemistry of these species is essential to integrating these fuels into our energy systems. More

NIMBUS Personalized Pipetting Workstation

MICROLAB® NIMBUS, first in a new class of personalized pipetting workstations, offering speed, flexibility, performance and affordability, all in a compact, space-efficient footprint.

China prepares for big entry into vaccine market
The Associated Press via Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
China's vaccine makers are gearing up over the next few years to push exports in a move that should lower costs of lifesaving immunizations for the world's poor and provide major new competition for the big Western pharmaceutical companies. However, it may take some time before some parts of the world are ready to embrace Chinese products when safety is as sensitive an issue as it is with vaccines. More

Track Cell Behavior Kinetically

Track cell behavior kinetically and reduce assay time with quantitative, reproducible data from within your incubator! Explore the IncuCyte and CellPlayer Kinetic Assays.
GO! >>>

Princeton technique puts chemistry breakthroughs on the fast track
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Scientists can now take that "a-ha" moment to go with a method Princeton University researchers developed — and successfully tested — to speed up the chances of an unexpected yet groundbreaking chemical discovery. The researchers report this month in the journal Science a technique to accomplish "accelerated serendipity" by using robotics to perform more than 1,000 chemical reactions a day with molecules never before combined. More


SCINOMIX’S SCI-PRINT VX2 is a small footprint multifunction vial handling system. The SCI- PRINT MP2+ is a high throughput fully automated barcode label printer for microtiter plates and deep well blocks. Click here to see product videos and more!

Reductive carboxylation supports growth in tumour cells with defective mitochondria
Nature    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Mitochondrial metabolism provides precursors to build macromolecules in growing cancer cells. In normally functioning tumour cell mitochondria, oxidative metabolism of glucose- and glutamine-derived carbon produces citrate and acetyl-coenzyme A for lipid synthesis, which is required for tumorigenesis. More

Corning® Bar Coded Storage Tubes
Corning Bar Coded Storage Tubes are a superior storage solution designed to provide maximum identification with synchronized 2D/linear bar codes and a marking spot on the tube side wall. Both 96 and 384 tube formats feature a 14 x 14 dot, 2D, laser-etched bar code.

Where does Geron's exit from embryonic stem cells leave the field?
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Geron, a pioneer in stem cell research founded in 1990, announced on Nov. 14 that it was halting its stem cell therapeutics programs to conserve funds. Geron had been developing cell products from differentiated human embryonic stem cells for multiple indications. The company is viewed as the leader in stem cell therapies because of its patents on technology used to grow, manipulate and inject stem cells into the human body. More


Low paternity skew and the influence of maternal kin in an egalitarian, patrilocal primate
Proceedings of the National Academy of Sciences    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Levels of reproductive skew vary in wild primates living in multimale groups depending on the degree to which high-ranking males monopolize access to females. Still, the factors affecting paternity in egalitarian societies remain unexplored. We combine unique behavioral, life history and genetic data to evaluate the distribution of paternity in the northern muriqui (Brachyteles hypoxanthus), a species known for its affiliative, nonhierarchical relationships. More

Neutrinos beat light speed once again
Popular Science    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Remember in September when neutrinos were observed moving faster than the speed of light, potentially overturning everything we thought we knew about physics? It was met with all sorts of skepticism and dubiety, so the physicists decided to replicate their experiment and take new measurements. Well, the new results are in, and they confirm the original findings. More

DNA Extraction WorkStation

Thermo Scientific Orbitor KingFisher Flex Extraction Workstation allows users to extract more nucleic acids/proteins in less time. The small, easy-to-use solution provides unattended walk-away time, better control of processes and greater sample consistency combined with an audit trails of all operations performed (time-stamped, stored records). Contact us to learn more.
Standardisation in Lab Automation - infoteam knows how
With SiLA (Standardisation in Lab Automation), we offer a standardised software foundation that enables easy integration of complex, automated systems. Modular systems controlled by the process management system can easily be replaced, separately tested and validated. Plug and play. We know how to connect you.
Tecan brings you HP Direct Digital Titration
Walk-up and use convenience for your drug discovery titrations.

Direct digital titration enables the fast delivery of picoliter to microliter sample volumes enabling a shorter titration process while at the same time providing results you can trust.

See how the HP Digital Titration Device can change your life.


Dean, Fenn College of Engineering
Cleveland State University
USA – OH – Cleveland

Faculty: Mechanical Engineering
KAUST (King Abdullah University of Science and Technology)
Saudi Arabia

QA Supervisor
USA – MD – Frederick

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Expert Advice/Stimulating Conversation

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SLAS Point-to-Point
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