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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit November 30, 2016

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Dec. 6 SLAS Webinar: Microengineered Culture Platforms for the Control of Cell-Cell Interactions
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Cellular organization plays a fundamental role in determining the emergent properties of living tissue. Elliot Hui, associate professor of biomedical engineering at the University of California, Irvine, leads a research group that is building a set of tools for the manipulation of microscale tissue architecture, enabling the study of contact-dependent signaling, paracrine gradients and cell-specific behavior within mixed cultures.

He shares the latest techniques from his lab during the Tuesday, Dec. 6, SLAS Webinar at noon EST. Dues-paying SLAS members may participate — live or on demand — at no cost. SLAS webinars are presented by the official scientific journals of SLAS.
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December Issue Now at JALA Online for Members and Subscribers
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Featured on the front cover and in a podcast, "Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module," reports how a module can be incorporated into different state-of-the-art pipetting robots for seamless integration into HTS processes.

Other original research reports include "Automated Device for Asynchronous Extraction of RNA, DNA, or Protein Biomarkers from Surrogate Patient Samples," "Implementation of an Automated High-Throughput Plasmid DNA Production Pipeline" and "Adapting a Low-Cost Selective Compliant Articulated Robotic Arm for Spillage Avoidance." SLAS Laboratory Automation Section members and JALA subscribers can view the issue online now.
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Register for SLAS2017 by Dec. 19 and Save!
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Save at least $200 off full conference registration fees by registering on or before Monday, Dec. 19. Full conference attendees enjoy access to the entire scientific program, including podium sessions, keynotes, the Exhibition, Career Connections, SIGs, provided meals, receptions and networking events, including the SLAS2017 exclusive event at the Newseum on Feb. 7.

Substantial discounts also are available for student attendees and groups; additionally, SLAS offers complimentary registration to individuals currently unemployed — download the waiver request form.
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From the SLAS President: Thanks for a Great Year!
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"'Giving back' is something you often hear people say when they talk about being a volunteer," says SLAS President Richard M. Eglen. "In fact, this was my personal goal when I joined the SLAS Board of Directors. I hope I've succeeded in this goal, because through the last 20 years SLAS truly has given a lot to me. With the diverse interests and expertise of its members, SLAS is a springboard for creative collaboration and success. I am so proud of the countless resources it makes available to members. Furthermore, I'm grateful for the positive impact our members are having as we work together to shape the future of life sciences discovery and technology."

Read more in the SLAS Electronic Laboratory Neighborhood e-zine.
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Breakthrough Technologies Showcased at SLAS2017
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Keep your browser pointed to the SLAS2017 New Product Announcements page, where SLAS2017 exhibitors announce the new products they plan to unveil at SLAS2017, Feb. 4-8 in Washington, DC.

On the growing list now are the BioTek Instruments Lionheart FX Automated Live Cell Imager, Covaris ME220 Focused-Ultrasonicator Sample Preparation System, Nanomedical Diagnostics AGILE R100 Label-Free Assay and TTP Labtech dragonfly 2 Liquid Handler.
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SLAS2017 Short Course Spotlight: Multiparametric Analysis of High-Content Screening Data
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Learn how to transform complex datasets into biological insights using advanced data mining techniques in the open source platform, KNIME. Short Course instructors Marc Bickle and Antje Janosch of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, walk students through data inspection and annotation; parameter selection; clustering and machine learning; hit calling; and more in this Sunday, Feb. 5, course at SLAS2017.

Participants should bring their laptops to install the required software in Washington, DC; no programming skills are required.
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Scientists Create Reagents to Simplify Production of Fine Chemicals and Pharmaceuticals
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The goop from pine trees that contains compounds known as terpenes is used in the manufacture of food, cosmetics and drugs, but it might become even more valuable as a chemical reagent made through a process developed by scientists at Rice University. The Rice lab of synthetic chemist László Kürti reported its success at creating highly efficient aminating and hydroxylating reagents from abundant and biorenewable terpenoids that promises to make the reagents' use environmentally friendly and cost-effective. More


Scientists Develop Vaccine Against Fatal Prescription Opioid Overdose
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Scientists at The Scripps Research Institute have developed a vaccine that blocks the pain-numbing effects of the opioid drugs oxycodone and hydrocodone in animal models. The vaccine also appears to decrease the risk of fatal opioid overdose, a growing cause of death in the United States. "We saw both blunting of the drug's effects and, remarkably, prevention of drug lethality," said Kim D. Janda, the Ely R. Callaway Jr. Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at TSRI. More


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Researchers Propose Solution to Gene Drive Technology Problem
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Gene drives are a promising technology for controlling the populations of disease-bearing mosquitos by using their own genes against them. But a number of roadblocks still stand in the way. The underlying concept of a gene drive is to engineer genes that will consistently be passed down to offspring, thereby spreading rapidly through a population. The hope for Zika, malaria, and dengue is that such genes could be engineered to either kill off female mosquitos or confer resistance to disease vectors. More


Researchers Develop Soft, Microfluidic 'Lab on the Skin' for Sweat Analysis
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A Northwestern University research team has developed a first-of-its-kind soft, flexible microfluidic device that easily adheres to the skin and measures the wearer's sweat to show how his or her body is responding to exercise. A little larger than a quarter and about the same thickness, the simple, low-cost device analyzes key biomarkers to help a person decide quickly if any adjustments, such as drinking more water or replenishing electrolytes, need to be made or if something is medically awry. More


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Protein Provides New Route to Carbon-Silicon Bonds
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Silicon is the second most abundant element in Earth's crust after oxygen, but carbon-silicon bonds are unheard of in nature: Neither biological organosilicon compounds nor biosynthetic pathways to create them have been identified. But when given the right starting materials, some heme proteins can stereospecifically form carbon-silicon bonds, report researchers from Caltech. "Nature's iron heme chemistry just jumps on this opportunity because we provided it with the right precursors," says Frances H. Arnold, who led the research. More


Evolution of a Protein Interaction Domain Family by Tuning Conformational Flexibility
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Conformational flexibility allows proteins to adopt multiple functionally important conformations but can also lead to nonfunctional structures. We analyzed the dynamic behavior of the enzyme guanylate kinase as it evolved into the GK protein interaction domain to investigate the role of flexibility in the evolution of new protein functions. We found that the ancestral enzyme is very flexible, allowing it to adopt open conformations that can bind nucleotide and closed ones that enable catalysis of phosphotransfer from ATP to GMP. More


Another Wrinkle Found for Cell Reprogramming in Vivo
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
If you look into the face of cellular reprogramming, what you see depends on whether it occurs in a culture dish or a living organism. As you might expect, living tissue has more context. Here, tissue damage and senescence provide crucial signals that can help push somatic cells toward an embryonic state. Properly scrutinized, these signals could help scientists improve regenerative medicine and reverse some of the maladies related to disease and aging. More


New Quantum States for Better Quantum Memories
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
How can quantum information be stored as long as possible? An important step forward in the development of quantum memories has been achieved by a research team of TU Wien. Conventional memories used in today's computers only differentiate between the bit values 0 and 1. In quantum physics, however, arbitrary superpositions of these two states are possible. Most of the ideas for new quantum technology devices rely on this "Superposition Principle." More




Career


Assistant/Associate Professor in Biological Engineering
University of Guelph
CN – ON – Guelph

Manager Quality Control
Genomic Health
US – CA – Redwood City

Biomedical Engineer
U.S. Food and Drug Administration
US – MD – Silver Spring

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