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Boost your career or find the perfect candidate. SLAS Career Connections offers both online and in-person career services.
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SLAS ELN Reports: Biological Image Processing and Analysis — Beyond Pretty Pictures
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"Learning how to do at least some level of image analysis will enable researchers to get answers faster, and perhaps spur investigations into more complex areas that they cannot explore with their current tools," says Matthew Fronheiser, Ph.D.
A senior biomedical engineer, Fronheiser shares his knowledge and experience of this hot topic, including how "image analysis can keep people from drawing the wrong conclusions from what they see" in the SLAS Electronic Laboratory Neighborhood e-zine.
The feature article is a good preview of the new SLAS2015 Short Course, "Digital Image Processing and Analysis for the Laboratory Scientist: Theory and Application," presented Feb. 8 by Fronheiser and colleague Mark Russo, Ph.D.
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SLAS Asia Council Vice Chair Wins 2014 Roche Chinese Young Investigator Award
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Congratulations to Lixin Zhang, deputy director of Key Laboratory of Pathogenic Microbiology & Immunology and inaugural director of Drug Discovery Center for Tuberculosis Institute of Microbiology, Chinese Academy of Sciences. He was one of 11 Chinese academic researchers honored for outstanding research, publication record and impact to the field of organic or bioorganic chemistry, medicinal chemistry or chemical biology particularly related to infectious diseases.
Zhang's research is focused on taxonomy-guided diversification of a marine microbial natural product library, high-throughput screening for synergistic medicines and increasing the production of druggable secondary metabolites from microbial producers by synthetic biology. Read more about Zhang's work in the Journal of Biomolecular Science, "Echinomycin, a Potential Binder of FKBP12, Shows Minor Effect on Calcineurin Activity." The award was presented Nov. 15.
Pictured is Zhang (center) with Hong Shen (left), Roche Innovation Center, Shanghai, China and Andrew Thomas (right), Roche Innovation Center, Basel, Switzerland.
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SLAS2015: Intelligent Network Building
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SLAS understands that the value of time spent in educational sessions at SLAS2015 is rivaled only by time spent meeting speakers, exhibitors and other conference participants.
Therefore, scheduled opportunities are built into the Feb. 7-11 schedule to make connections within the community.
Receptions in the Exhibition, special discounts at SLAS2015 "corner bars" and the SLAS2015 Tuesday Night Celebration, Blast Off with SLAS at the Smithsonian National Air and Space Museum sponsored by Hamilton Company, are among the ways SLAS2015 delivers a means for continued collaboration.
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JALA December Podcast: Automated Microfluidic Platform with Customized Molecular Assays
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Sandia National Laboratory author Meiye Wu discusses her JALA December technology brief, "Microfluidic Molecular Assay Platform for the Detection of miRNAs, mRNAs, Proteins, and Posttranslational Modifications at Single-Cell Resolution," in a new podcast at JALA Online.
"“We describe our automated microfluidic platform with a portfolio of customized molecular assays that can detect nucleic acids, proteins, and posttranslational modifications in single intact cells with >95% reduction in reagent requirement in under eight hours," Wu says. "Single cell resolution is becoming more important because as we learn more about cell signaling, we're trying to understand that cells don't behave homogeneously especially in certain cases like immunology or development where just a few cells at critical times can lead to huge organism level differences in response."
Access this article and more in the JALA December Table of Contents.
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Congratulations to SLAS Young Scientist Delegate from Madrid
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Mario de la Fuente, Instituto de Química Médica (IQM-CSIC), Madrid, Spain, was named an SLAS Young Scientist Delegate at the Nov. 20-21 Spanish Drug Discovery Network meeting, Novel Strategies for Drug Discovery.
The student's winning poster was titled "Melatonin-based Compound MF316 Stimulates Adult Brain Neurogenesis and Mitochondrial and Cognitive Function: Potential Role as a Neuroprotective Agent."
In conjunction with this distinction, de la Fuente receives a $500 cash prize, roundtrip airfare, hotel accommodations and full conference registration for SLAS2015, Feb. 7-11, 2015, Washington, D.C.
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2015 JALA & JBS Art of Science Contest Entries Due Dec. 24
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Submit scientific images that attract attention, are fun to look at and stimulate the imagination! One grand prize winner will receive a fully paid registration to SLAS2016, Jan. 23-27, 2016, in San Diego, CA.
Ten finalists will receive autographed copies of the book I Heard the Sirens Scream: How Americans Responded to the 9/11 and Anthrax Attacks by SLAS2015 keynote speaker Laurie Garrett, plus 60 days free online access to the SAGE Pharmacology & Biomedical Collection (nearly 100,000 articles!). Entries are due by Dec. 24, 2014.
Read about last year's winners in the SLAS e-zine.
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Washington, DC: Easy In, Easy Out and Plenty to Do in Between
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The U.S. capital city offers convenient access for SLAS2015 domestic and international travelers by way of three regional airports and Amtrak train service.
Once in the city, many local attractions, like the National Mall and Smithsonian museums, are within walking distance of a Metrorail or Metrobus stop. The Renaissance Washington D.C. Downtown and Marriott Marquis Washington, D.C. will honor the SLAS2015 negotiated discount rates from Feb. 4-14 (based on availability) for those booking by Jan. 7 through SLAS2015 official channels.
Plan to add a day to your visit to experience Washington, D.C.
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A Hybrid Vehicle That Delivers DNA
Bioscience Technology Share
A new hybrid vehicle is under development. Its performance isn't measured by the distance it travels, but rather the delivery of its cargo: vaccines that contain genetically engineered DNA to fight HIV, cancer, influenza and other maladies.
Described recently in the Proceedings of the National Academy of Sciences, the technology is a biomedical advancement that could help unleash the potential of DNA vaccines.
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Hydrogen-Bonded Organic Semiconductor Micro- And Nanocrystals: From Colloidal Syntheses to (Opto-)Electronic Devices
Journal of the American Chemical Society Share
Organic pigments such as indigos, quinacridones, and phthalocyanines are widely produced industrially as colorants for everyday products as various as cosmetics and printing inks. Herein we introduce a general procedure to transform commercially available insoluble microcrystalline pigment powders into colloidal solutions of variously sized and shaped semiconductor micro- and nanocrystals.
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Unraveling Ebola to Develop Effective Drugs
Chemical & Engineering News Share
After Craig Spencer, the American doctor who contracted Ebola while volunteering in Guinea, walked out of a New York City hospital last month, national anxiety over Ebola seemed to dissipate. Days earlier, quarantines had been lifted on those who had interacted with him. America relaxed, but the epidemic rages on in West Africa. Even as evidence mounts that the outbreak is abating in some regions, flare-ups in other areas make experts reluctant to say the epidemic is under control.
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Expanding the Analytical Toolbox: Pharmaceutical Application of Quantitative NMR
Analytical Chemistry Share
In response to the changing market pressures being applied to the pharmaceutical industry, a greater emphasis is being made to advance new drugs to market with minimal investment in early development stages. The use of quantitative NMR (q-NMR) has been shown to be a single point replacement for routine early development testing which previously combined elements of identity testing, chromatographic assay, moisture analysis, residual solvent analysis, and elemental analysis.
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Biochemists Identify Molecular Structures That Allow Immune System to Tell Friend From Foe
Phys.org Share
To repel an infection, the body's immune system has to tell the enemy — bacteria or other invaders — from cells of its own body. To achieve this distinction, the immune system utilizes characteristic molecular patterns displayed on the surface of each cell. One of these molecular patterns has now been identified by Dr. Bärbel Blaum and Professor Thilo Stehle of Tübingen's Interfaculty Institute of Biochemistry, working in cooperation with researchers in the U.K. and Colorado.
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Sweet Smell of Success: Researchers Boost Methyl Ketone Production in E. Coli
Science Daily Share
Two years ago, researchers at the U.S. Department of Energy's Joint BioEnergy Institute (JBEI) engineered Escherichia coli (E. coli) bacteria to convert glucose into significant quantities of methyl ketones, a class of chemical compounds primarily used for fragrances and flavors, but highly promising as clean, green and renewable blending agents for diesel fuel. Now, after further genetic modifications, they have managed to dramatically boost the E.coli's methyl ketone production 160-fold.
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Verifying the Quality and Quantity of your ChIP DNA
Porvair Sciences Share
Porvair Sciences has published a new guide to help laboratories choose the best way to verify the quality and quantity of their Chromatin Immunoprecipitation (ChIP) DNA. The guide reports on experiments undertaken to compare the performance of three products for qualitative and quantitative analysis of double stranded immunoprecipitated DNA. The advantages and limitations of detection sensitivity, reproducibility and automated analysis of each instrument are discussed, as is the compatibility of each method with downstream applications including next generation sequencing.
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ISBER Announces 2015 Annual Meeting & Exhibits Symposia Topics
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The International Society for Biological and Environmental Repositories (ISBER) meets May 5-9, 2015 in Phoenix, AZ, and offers the following symposia:
- Laying Foundations: Spanning diverse contexts, creating high-impact environments
- Paddling Upstream: Coupling valid downstream assay results to biospecimen quality and management
- Corralling Biobank Informatics: Joining informatics infrastructure and practices to biobanks for large-scale research
- Building Bridges: Engaging participants, communities and the public in human and enviro-bio specimen repositories
- Late-Breaking Topics
- Crossing the Bridge: Advancing scientific discovery through collaborative use of environmental and biological samples
ISBER welcomes abstract submissions by Jan. 9, 2015.
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Research Scientist I – HTS Automation
Vertex Pharmaceuticals
US – CA – San Diego
Postdoctoral Position in Biomaterials and Biochemicals
University of Alberta
CA – AB – Edmonton
Research Support Specialist, High-Throughput Screening Facility
The Rockefeller University
US – NY – New York
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