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December 6, 2017

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Professors — Would $100,000 Help You Support an Exceptional Graduate Student's Work?
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SLAS believes so. As do Elliot Hui from the University of California, Irvine and Amy Herr from the University of California, Berkeley, whose students Erik M. Werner and Julea Vlassakis, respectively, were the 2016 and 2017 winners of the SLAS Graduate Education Fellowship Grant. Applications are due Dec. 11 for the 2018 SLAS grant which facilitates educational opportunities for outstanding students pursuing graduate degrees related to quantitative biosciences and/or life sciences research. Hui and Herr appreciate the flexibility of the SLAS award.

"Some grants and industry funding have set deliverables, but this grant will allow Julea to move toward a goal while maintaining some element of creativity, which is important in the most innovative research," Herr says. More

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LAST CALL! Abstracts Due Dec. 8 for 2018 SLAS Europe Conference and Exhibition
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SLAS transforms research at this premier event for the European life sciences discovery and technology community, July 27-29, 2018, in Brussels, Belgium.

Submit an abstract today for the opportunity to present your research, gain insight from an informed scientific audience and explore commercialization and partnership opportunities. You can't benefit if you don't apply by Dec. 8. More

Dec. 12 SLAS Webinar: How AstraZeneca is Revolutionizing Sample Management With Acoustic Tube-Based Technologies
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Open to SLAS members and non-members alike, this SLAS webinar is held live Dec. 12 and then available on demand.

Kevin Cross, senior scientist, sample management at AstraZeneca, discusses the benefits of adopting the new acoustic tube technology and how AstraZeneca is approaching its integration into its sample management infrastructure. Justin Jager, product manager, lab automation at Labcyte, provides an overview of the new automated system and highlights how it addresses the needs of sample management teams at AstraZeneca. More

Still using Excel for Informatics?

Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report, learn how viDA Therapeutics streamlined their processes and improved collaboration.

SLAS Ignite Facilitates Connections: Six Presentations Scheduled for SLAS2018
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The SLAS Ignite Academic Theater debuts at SLAS2018 to help life sciences researchers tap into the experience, insights and capabilities of peers and complementary organizations to develop the medicines and innovations that improve the human condition. Scheduled presentations Feb. 5-6 from 1:00-2:00 p.m. are:

Introduction to Disulfide Trapping, A Site-Directed Fragment Screening Technology
Michelle Arkin, Associate Professor, Pharm Chem; Co-Director, Small Molecule Discovery Center, University of California, San Francisco

Combinatorial Drug Discovery in Nanoliter Droplets
Paul Blainey, Associate Professor of Biological Engineering and Core Member, MIT Department of Biological Engineering and Broad Institute of MIT and Harvard

Microreactor Based Online Reaction Monitoring Using Mass Spectrometry for Structural and Elemental Measurements
Heidi Fleischer, Ph.D. Student, University of Rostock

A Large-Scale Microfluidic Technology for High-Content Screening of C. elegans using Commercial Imaging Platforms
Sudip Mondal, Research Associate, The University of Texas at Austin

Label-Free Raman Spectroscopy for Rapid Identification of Biologics
Santosh Paidi, Graduate Research Assistant, Department of Mechanical Engineering, Johns Hopkins University

Identifying New Drug Targets by Illuminating the Druggable Genome
Aaron Pawlyk, Senior Advisor, National Institutes of Health

Click titles above for presentation details. More

With Respect and Gratitude: My Year as SLAS President
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As Scott Atkin wraps up his year-long term as SLAS president, he expresses his thanks and kudos to fellow members of the SLAS Board of Directors, the SLAS professional team and especially to the countless volunteers who drive the Society.

"I can say with confidence that my three years of service on the SLAS Board of Directors were tremendously inspiring, enlightening and rewarding," Atkin says. "I feel privileged to have worked alongside one of the most dedicated and committed teams I've met in my career." Read more in the SLAS Electronic Laboratory Neighborhood e-zine. More

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Scientists Propose Efficiency 'Rules' for Enhancing Use of New Gene Editing Technology
Lab Manager Share

Johns Hopkins scientists have developed a streamlined method and accompanying efficiency "rules" for introducing new DNA sequences into cells after using the gene-cutting tool known as CRISPR. The scientists say the method, which they based on tests with mouse embryos and thousands of human cells, could improve consistency and efficiency of genome editing. The new method and its development are described online in the Proceedings of the National Academy of Sciences. More

CRISPR Rules When It Obeys the CRISPR Rules
Genetic Engineering & Biotechnology News Share

When the gene-editing system known as CRISPR is used, DNA breaks occur fairly reliably, but not DNA repairs — specifically, the repairs that are supposed to insert synthetic donor DNA. But repairs may be more likely to "stick," say Johns Hopkins scientists, if donor DNA is designed properly. The scientists suggest that homology-directed repair, the usual mechanism for knockin of new genetic material, is more efficient if a few design rules are followed. More

Solving compound inventory needs at Epizyme

Hear Epizyme's Elizabeth Admirand review their reasons for choosing Titian's Mosaic sample management software to solve their research need for accurate compound inventory and tracking of Epizyme's biological samples.

Are you looking to upgrade your compound management? Talk to the experts at Titian Software.

SERS Detection of Multiple Antimicrobial-Resistant Pathogens Using Nanosensors
Analytical Chemistry Share

Successful pathogen detection is crucial for public health as the threat of infectious disease is dramatically increasing globally due to bacteria developing resistance to many antimicrobial drugs. The increase in bacterial infections has led to urgent demands for simpler, faster and more reliable detection methods to be developed allowing the most appropriate therapy to be provided. More

Ligands Make the Difference! Molecular Insights into Cr^VI/SiO₂ Phillips Catalyst during Ethylene Polymerization
Journal of the American Chemical Society Share

Operando-sensitive spectroscopic techniques were employed for investigating the changes in the molecular structure of the Cr sites in the Cr^VI/SiO₂ Phillips catalyst during ethylene polymerization. Practically, the most arduous barrier to be overcome was the separation of the chromates reduction carried out by ethylene from the subsequent polymerization. By carefully tuning the experimental parameters we succeeded in observing these two events separately. More

Programmable Drug Delivery Platform Combats Diseased Cells at Genetic Level
Science Daily Share

A new drug delivery system that uses a synthetic-biological hybrid nanocapsule could provide a smart technology for targeted treatment of a variety of serious diseases at the genetic level. The hybrid offers a way to correct diseased cells at the genetic level — while at the same time leaving healthy cells alone — to increase the effectiveness of treatments and reduce unwanted side effects. More

Scientists Craft World's Tiniest Interlinking Chains
Phys.org Share

For decades, scientists have been trying to make a true molecular chain: a repeated set of tiny rings interlocked together. In a study in Science published online, University of Chicago researchers announced the first confirmed method to craft such a molecular chain. Many molecules described as "linked" are joined with fixed covalent bonds — not two freely moving interlocked rings. More

US FDA Wants More Generic Drug-Device Combos
Chemical & Engineering News Share

U.S. Food & Drug Administration Commissioner Scott Gottlieb is continuing his push for cheaper drugs by making approvals of generics easier. FDA is committed to giving guidance on how companies can develop copycat products on complex drugs at least two years before the branded product's patent expires, Gottlieb said. He spoke at FDA's Generic Drug Science Day in Silver Spring, Maryland. More

Getting at the Gut: Establishing Germ-free Models for Preclinical Research
Bioscience Technology Share

Less than four years since the groundbreaking study linking gut microbiota to obesity, the race to develop microbiome therapies is in full sprint. Microbiome-focused biotech companies and pharmaceutical divisions are popping up in an effort to discover treatments for diseases ranging from autism, neurological disease, metabolic disorder, C. difficile, inflammatory bowel disease, asthma, cancer, diabetes and more. More

Career

Post-Doctoral Research Fellow
Burke Medical Research Institute
US – NY – White Plains

Clinical Research Coordinator
University of Washington
US – WA – Seattle

Scientists and Directors
Primary Peptides Inc.
China – Qingdao

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