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Eight Exciting Entrepreneurs Earn Invitations to SLAS2017 Innovation AveNEW
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These promising new start-up companies kick off 2017 by bringing their novel technologies to the SLAS2017 Exhibition. Selected by a panel of judges from a pool of impressive applicants, these SLAS Innovation AveNEW entrepreneurs earn complimentary exhibit space, travel, hotel and conference registration; all to put them and their scientific innovations face-to-face with the world-class professionals at SLAS2017 in Washington, DC, Jan. Feb. 4-8. Congratulations to:
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SLAS ELN Reports: Uniting Phenotypic and Target-Based Drug Discovery
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Many people see target-based drug discovery and the phenotypic approach to drug discovery as antagonistic but Fabien Vincent, associate research fellow in the Department of Hit Discovery and Lead Profiling at Pfizer, sees them as complementary. This is the message he and fellow presenter David Swinney hope to convey during the SLAS2017 session "Uniting Phenotypic and Target-based Drug Discovery," part of the Drug Target Strategies Track.
"It's not us vs. them," Vincent says. "We are likely going to be more successful when we intelligently combine the two."
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SLAS Journal News
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Two new scientific reports are now available ahead-of-print for FREE to all readers at JBS Online. An original research paper by Ioannis K. Moutsatsos et al. and a technical note by Andreas Stengl et al. reflect the quality and diversity of peer-reviewed science published by the SLAS journals.
Jenkins-CI, an Open-Source Continuous Integration System, as a Scientific Data and Image-Processing Platform
A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies
Coming soon: Readers will begin seeing the SLAS journals identified by their new names (SLAS Discovery and SLAS Technology) within the next week. While the names are changing, the journals' trusted commitment to innovation is not changing. Their editorial rigor, integrity, aims and scope remain solidly in place.
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SLAS Europe Translating Research Ideas Into Future Therapeutics Conference a Success
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A highly engaged group of academic scientists, innovative start-ups and funding organizations from across Europe gathered to discuss how to streamline project selection to deal making at the Nov. 29-30, 2016, conference in Leuven, Belgium.
"Participants had a wonderful opportunity to talk at length with each other about their projects, learn from one another’s experience, build new alliances and create new development partnerships," notes Caroline Gutierrez, SLAS Europe director.
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Yes! You Can Publish Open Access with SLAS Journals
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Authors who wish to make their work freely available immediately upon publication in SLAS journals may do so for a fee of $3,000. Typically, access to scientific content is limited to SLAS members and subscribers and available on a pay-per-view basis until one year after final (print) publication. But this is not mandatory.
SAGE Choice (gold open access) ensures authors can comply with funding mandates and helps authors attract more readership more quickly.
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SLAS2017 Short Course Spotlight: Next Generation Sequencing Technology Fundamentals and Applications
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Next generation sequencing (NGS) has revolutionized genomics. It has created a novel set of applications and industries in such diverse fields as agriculture, the environment, human origins, infectious diseases and human health. Besides introducing basic concepts, this course provides a glimpse of future through groundbreaking applications.
Course instructors are Dawei Lin of the Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and Abizar Lakdawalla of Proxeom. Next Generation Sequencing Technology Fundamentals and Applications is one of 21 Short Courses to be held at SLAS2017.
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Scientists Use CRISPR for First Time to Correct Clotting in Newborn and Adult Mice
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CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations. For the first time, researchers from the Perelman School of Medicine at the University of Pennsylvania have developed a dual gene therapy approach to deliver key components of a CRISPR/Cas9-mediated gene targeting system to mice to treat hemophilia B. This disorder is also called factor IX deficiency and is caused by a missing or defective clotting protein.
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Turning Blood Cells Into Light-Controlled Drug Carriers
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Red blood cells, the most numerous type of cell in the body, can act as light-activated drug delivery vehicles, according to a new study. The technique traps drugs in the cells, where they could circulate for the cells' four-month lifetimes. Red or infrared light shone on a patient's skin or through an inserted fiber optic could release the trapped drugs when and where they are needed.
In the technique, David S. Lawrence of the University of North Carolina, Chapel Hill, and coworkers first covalently attach a drug and a fluorescent molecule to cobalamin, the core structure of vitamin B-12.
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Survey of Approved Drugs Intended to Shed Light on Potential New Therapies
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Researchers have created a map of all 1,578 licensed drugs and their mechanisms of action as a means of identifying "uncharted waters" in the search for future treatments. Their analysis of drugs licensed through the U.S. FDA reveals that 667 separate proteins in the human body have had drugs developed against them — just an estimated 3.5% of the 20,000 human proteins.
And as many as 70% of all targeted drugs created so far work by acting on just four families of proteins, thus leaving vast swathes of human biology untouched by drug-discovery programs.
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USPTO to Hear Arguments on CRISPR Patents
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CRISPR, the gene-editing technology that has taken the scientific community by storm, will have its day in court as three judges at the United States Patent and Trademark Office hear oral arguments to decide who owns the valuable intellectual property over its use.
"The Broad Institute [of MIT and Harvard] is requesting priority based on its patent application filed on December 12, 2012," Life Sciences Intellectual Property Review reported.
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Congress Poised to Back NSF's Approach to Research
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Congress has reached a truce — and possibly a lasting settlement — in the fiercely partisan three-year war between Republican leaders in the House of Representatives and the scientific community over how the National Science Foundation should operate. The terms of the agreement, between House and Senate negotiators, may seem like minor changes. But the compromise, which the Senate could adopt as early as this week, resolves differences over how NSF should conduct peer review and manage research in ways that the agency thinks it can live with.
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New Method Improves Stability, Extends Shelf Life of Protein Drugs
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Gaining access to important biopharmaceuticals needed to treat illnesses and autoimmune diseases is one of the biggest obstacles developing countries face. Costs can be astronomical where these medications are needed most, and when doctors are able to acquire those medications they face another challenge — time. Drugs are perishable and some require refrigeration, which can be difficult to provide in the world's poorest regions.
Now, a new study appearing in the Proceedings of the National Academy of Sciences reveals a new way to improve the stability of common protein drugs and extend shelf life.
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Researchers Uncover More Genetic Links to Brain Cancer Cell Growth
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Two recently discovered genetic differences between brain cancer cells and normal tissue cells — an altered gene and a snippet of noncoding genetic material — could offer clues to tumor behavior and potential new targets for therapy, Johns Hopkins scientists report.
In a report on one of the two findings, published online in Acta Neuropathologica, the investigators identified alterations in a protein known as ATRX in human brain tumors that arise as part of a genetically inherited condition known as neurofibromatosis type 1.
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Names and Symbols of 4 Newly Discovered Elements Announced
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On Nov. 28, the International Union of Pure and Applied Chemistry (IUPAC) approved the name and symbols for four elements: nihonium (Nh), moscovium (Mc), tennessine (Ts) and oganesson (Og), respectively for element 113, 115, 117 and 118.
Following a 5-month period of public review, the names earlier proposed by the discoverers have been approved by the IUPAC Bureau.
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Advance Registration: Dec. 19, 2016
Discounted Hotel Reservations: Jan. 5, 2017
Poster Submissions: Jan. 23, 2017
Senior Scientist, Discovery Oncology
Genentech
US – CA – South San Francisco
Staff Scientist
National Institute on Deafness and Other Communication Disorders
US – MD – Bethesda
Assistant/Associate Professor in Biological Engineering
University of Guelph
CN – ON – Guelph
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