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SLAS
Learn more about the six presentations selected to be part of the SLAS Ignite Academic Collaboration Presentations. Academic researchers awarded this opportunity will present 15-minute podium presentations in the SLAS Exhibition Theater to help them connect with collaborative partners among our diverse community of engineers, researchers, scientists, business leaders and pioneering academic experts. Congratulations to this year's participants:
- Integration of Biotherapeutics in Combination Screening with Small Molecule Libraries
Matthew Hall, Ph.D., National Center for Advancing Translational Science (NCATS), Bethesda, MD, USA
- Quantitative and Scalable Cell Separation using Magnetic Ratcheting Cytometry
Coleman Murray, M.Sc., University of California Los Angeles, Los Angeles, CA, USA
- A Novel Label-Free Dip Sensor to Facilitate Drug Discovery Screening and Development Effort
Natalie Luo, B.Sc., New York University, New York, USA
- Rapid Point of Care Diagnostic Platforms Using Raman Spectroscopy
Soumik Siddhanta, Ph.D., Johns Hopkins University, Baltimore, MD, USA
- An Additive Biomanufacturing Platform to Automate and Accelerate the Discovery Process for 3D Cell Culture Models
Sebastian Eggert, Ph.D. Candidate, Queensland University of Technology, Brisbane, Australia
- Configurable Micro-Physiological Systems
Pulak Nath, D.Eng., Los Alamos National Labs, Santa Fe, NM, USA
See Event Scheduler for presentation times.
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SLAS
There's still time to submit a poster abstract for SLAS2019 (Feb. 2-6, 2019, Washington, DC, USA)! Poster presentation sessions provide the perfect venue for one-on-one discussion, collaboration and feedback. If accepted, you gain an opportunity to communicate your research to a focused and passionate group of life sciences discovery and technology colleagues. Posters will be on display for the duration of the SLAS Exhibition. Space is limited. Final poster abstracts due Jan. 21, 2019. Avoid the holiday rush! Register now for SLAS2019 and save $200 off advanced registration rates until Dec. 17!
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SLAS
The Scientific Program Committee for the 2019 European Sample Management Symposium (March 11-12, 2019, Berlin, Germany) is accepting abstracts for podium presentations. Sample management has become increasingly important in every phase of chemical and biological discovery. Control over factors such as sample quality, process efficiency, metadata and miniaturization must be achieved to accelerate both academic and industrial programs. Further complexity arises in maintaining these factors when collaborating with an external research partner. The symposium welcomes all compound and sample management professionals — from bench scientists to senior leaders — to obtain fresh perspectives and share innovative solutions to challenges in these domains. The deadline for podium abstracts submissions is Monday, Dec. 17.
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SLAS
Listen and learn: A NEW SLAS Technology Podcast is available featuring University of Kansas researchers Yangjie Wei and Nicholas Larson. Wei and Larson discuss how they used a steady-state/lifetime fluorescence-based, high-throughput platform to develop a general workflow for direct formulation optimization under analytically challenging but commercially relevant conditions.
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SLAS
There's still time to submit an application for either the 2019 SLAS Graduate Education Fellowship Grant or the SLAS Visiting Graduate Researcher program. The fellowship grant facilitates educational opportunities for outstanding students pursuing graduate degrees related to quantitative biosciences and/or life sciences research. The visiting graduate researcher program is a stipend for North American or European degree-seeking graduate students to conduct short-term doctoral research or participate in a mentored or independent research project with a faculty member at a different host institution.
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Anton Paar’s Modular Sample Processor allows pipetting, sampling, dosing and weighing to be automated. Available as a benchtop unit or a complete solution integration. MORE
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SLAS
Join the SLAS Journals' editors-in-chief on Wednesday, Feb. 6, at SLAS2019 (Feb. 2-6, 2019, Washington, DC, USA) for a step-by-step overview of how to design and write scientific research papers more clearly and effectively to improve their chances for publication. Attendees will learn what editors want, what they don't want, common mistakes, insider tips and how reviewers evaluate manuscripts. Presented by SLAS Discovery Editor-in-Chief Robert M. Campbell, Ph.D., (Eli Lilly & Co.) and SLAS Technology Editor-in-Chief Edward Kai-Hua Chow, Ph.D., (National University of Singapore). All SLAS2019 participants are welcome and encouraged to attend. Learn more about the SLAS Journals at the SLAS Journals Information Station, located in the SLAS Booth at SLAS2019. Learn about the journals' editorial scope, enter to win a Quadcopter Video Drone (a $500 value!) and find out more about important author services such as ORCID, Kudos and Altmetrics.
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SLAS
Learn more about the integration of low-cost sensors and microcontrollers to build tools for laboratory applications such as monitoring and control at SLAS2019. Join James M. Gill, II, of BFL Consulting (Madison, CT, USA) and 2016 SLAS Graduate Education Fellowship Grant recipient Erik M. Werner, University of California, Irvine (Irvine, CA, USA), as they present this SLAS Short Course that will review how laboratory hardware can be connected with cloud-based systems to create a laboratory or enterprise-wide network for real time data collection and analysis. The course will provide hands-on experience with the popular ESP8266 microcontroller and Arduino programming environment. Participants will walk through installation of the development environment, hardware testing, data collection, data analysis, controlling switches and cloud integration.
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Journal of the American Chemical Society
Researchers report a biocatalytic platform of engineered cytochrome P450 enzymes to carry out carbene-transfer reactions using a lactone-based carbene precursor. By simply altering the heme-ligating residue, researchers obtained two enzymes that catalyze olefin cyclopropanation (Ser) or S–H bond insertion (Cys). Both enzymes exhibit high catalytic efficiency and stereoselectivity, thus enabling facile access to structurally diverse spiro[2.4]lactones and α-thio-γ-lactones.
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Science Magazine
The scaffold protein p62 has a critical role in autophagy, the regulated degradation of proteins and organelles, and xenophagy, an autophagic process that clears invading pathogens and that may require the activation of Toll-like receptors (TLRs). Sanchez-Garrido et al. (see also the Focus by Martens) found that in skin fibroblasts, stimulation of TLR3, which detects double-stranded RNA typical of microbial pathogens, resulted in the generation by the protease caspase-8 of a proteolytic fragment of p62 that the authors called p62TRM.
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Contact us to put our Discovery expertise to work for you, contact: Customerservice@amriglobal.com.
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Lab Manager
The idea of a cancer vaccine is something researchers have been working on for more than 50 years, but until recently they were never able to prove exactly how such a vaccine would work.
Now, a team of researchers at the Institute for Research in Immunology and Cancer (IRIC) at Université de Montréal has demonstrated that a vaccine can work. Not only that, it could become an extremely effective, non-invasive and cost-effective cancer-fighting tool.
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Laboratory Equipment
Over the past decade we've learned that billions of people carry a mysterious specter in their DNA that strongly increases their risk for life threatening cardiovascular diseases, such as heart attacks, aneurysms or strokes, no matter what diet, exercise or medical regimen they follow.
Now, Scripps Research scientists have made a major breakthrough in unveiling this medical mystery by precisely cutting the DNA culprit from the genome, which prevents blood vessel cell abnormalities related to these devastating diseases.
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Explore the best combination of kits and instruments to ensure gentle and fast isolation of primary cells for your drug discovery and in vitro assays. Curious? Watch our video on high-throughput cell isolation using the MultiMACS™ X Cell Separator for maximum efficiency and reproducibility.
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Science Daily
The wonders of graphene are numerous — it can enable flexible electronic components, enhance solar cell capacity, filter the finest subatomic particles and revolutionize batteries. Now, the "supermaterial" may one day be used to test for amyotrophic lateral sclerosis, or ALS — a progressive, neurodegenerative disease which is diagnosed mostly by ruling out other disorders, according to new research from the University of Illinois at Chicago published in ACS Applied Materials & Interfaces.
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Phys.org
A new study by investigators from Brigham and Women's Hospital provides a biophysical and structural assessment of a critical immune regulating protein called human T-cell immunoglobulin and mucin domain containing protein-3 (hTIM-3). Understanding the atomic structure of hTIM-3 provides new insights for targeting this protein for numerous cancer and autoimmune therapeutics currently under clinical development.
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Genetic Engineering & Biotechnology News
Broken bones heal more quickly in the young, presumably because a youthful circulation invigorates the bone repair process. A youthful circulation has even been shown to rejuvenate fracture repair in the old. This we know from experiments in which paired mice, young and old, were surgically connected, as well as studies of old mice that received bone marrow transplants from young mice. What we haven't known, however, is exactly how youthful blood promotes healing.
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Chemical & Engineering News
Last week's report that the first gene-edited babies were born in China raised many questions about the safe and ethical use of technologies such as the CRISPR-Cas9 gene-editing tool deployed in the process. Little attention, though, was paid to the technology vendor's responsibility to guard against misuse.
Questions of vendor ethics are similar to those raised in the contentious debate over gun sales in the U.S.
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