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December 13, 2017

SLAS.org SLAS2018 Moving? New job? Let SLAS know.

SLAS ELN Reports: Cathy Tralau-Stewart — Creating the Secret Sauce for Translational Science
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With 25-plus years of drug discovery experience spanning both industry and academia, SLAS Board of Directors member Cathy Tralau-Stewart, Ph.D., could write a book about the meticulous work required for a drug compound to progress through the pipeline. In her role at University of California, San Francisco's Catalyst Program, she unites various collaborators to keep breakthrough science in motion.

"I wanted to bring the orchestrated drug discovery effort that one finds in industry into academic settings," says Tralau-Stewart. "How you blend academia, industry and other funders together makes great science move forward — it's the secret sauce." Read more in the SLAS Electronic Laboratory Neighborhood e-zine. More

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Ten Good Reasons to Register for SLAS2018 before Dec. 18
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1. Up to $210 off registration rates. (Become an SLAS member to qualify for even deeper discounts.)
2. Upwards of 6,000 life sciences discovery and technology professionals from around the world
3. 140 scientific podium presentations
4. Two world-renowned keynote speakers
5. Dozens of informative exhibitor tutorials
6. SLAS Ignite presentations in the new SLAS Theater
7. SLAS Career Connections programs and events
8. 300 of the world's most important companies in the Exhibition
9. Morning coffee and lunches for all attendees
10. Special evening celebration in Old Town San Diego More

Schedule a Personal Consultation with an SLAS Journal Editor at SLAS2018
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The editors-in-chief of SLAS Discovery and SLAS Technology invite SLAS2018 attendees to register for 15-minute one-on-one personal consultations during SLAS2018. Share your ideas, ask questions and get to know the thought leaders who make the final decisions about what gets published in the SLAS journals. Meetings will be held in the Exhibition (admission is free). Appointments are being accepted now on a first come, first served basis — contact nhallock@slas.org.

See what else is going on in the SLAS Journals Information Station at SLAS2018. More

Still using Excel for Informatics?

Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report, learn how viDA Therapeutics streamlined their processes and improved collaboration.

Enter the SLAS2018 Student T-Shirt Design Contest by Jan. 5
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Express yourself and your unique perspective on life sciences discovery and technology by submitting a design for the SLAS2018 student T-shirt (NEW this year!). Capture that winning blend of science, humor and creativity using images, words or both, then see your design all around San Diego on SLAS2018 students.

Winner will earn a $50 Amazon gift card and free SLAS Premier Membership. More

ACS Reviewer Lab: Free Training Benefits Authors and Reviewers
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A new (and free) interactive online training program from the American Chemical Society (ACS) prepares volunteers interested in serving as manuscript reviewers and provides authors with excellent insight into how papers are critically assessed when being considered for publication in peer-reviewed journals.

The program requires 3-4 hours to complete and users must score at least 90% to graduate. More

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Molecules of the Year
Chemical & Engineering News Share

A persulfurated coronene, a molecule dubbed a "sulflower" for its resemblance to a sunflower, bloomed this year. It's the first fully sulfur-substituted polycyclic aromatic hydrocarbon and only the second member of a new class of circular heterocyclic carbon sulfide compounds, after the synthesis of octathio[8]circulene a decade ago. Chemists hope to create other class members, including the simplest one, persulfurated benzene, for use in battery cathodes and other electronic materials. More

Blueprints for Anti-Cancer Drugs Discovered in Bacterial Genomes
Phys.org Share

Scientists on the Florida campus of The Scripps Research Institute (TSRI) who had previously discovered the prostate cancer-killing compound LNM E1 have now brought the family of LNM molecules even closer to clinical testing by "mining" the information stored in bacteria genomes. Their research suggests these hidden genes hold the blueprints for designing new, even more effective cancer-targeting compounds. More

SLAS2018 Tutorial Closes The Screening Loop

Titian, HighRes and Genedata's SLAS2018 tutorial 'Partnering to Close the Screening Loop' demonstrates a seamless workflow to support the iterative drug discovery life cycle of designing, planning, testing and analysing. The approach effortlessly moves information to where it needs to be.

Register to receive this tutorial recording.

Scientists Craft World's Tiniest Interlinking Chains
Science Daily Share

For decades, scientists have been trying to make a true molecular chain: a repeated set of tiny rings interlocked together. In a study in Science published online Nov. 30, University of Chicago researchers announced the first confirmed method to craft such a molecular chain. Many molecules described as "linked" are joined with fixed covalent bonds — not two freely moving interlocked rings. The distinction makes a big difference when it comes to how the chain moves. More

New Online Database Brings the Genome into Focus Using Molecular Structure
Lab Manager Share

Iowa State University researchers have built an accessible online database that brings critical genomic data into sharp focus with the single click of a mouse. In an article published Dec. 8 in the journal Scientific Reports, a team of Iowa State University researchers presented a novel database that allows scientists to quickly access information on RNA structures encoded within the human genome. The database is freely accessible to anyone on the web. More

CRISPR/Cas9 Edits Epigenome with Therapeutic Efficiency
Genetic Engineering & Biotechnology News Share

The kindest cut may be no cut or, in the case of genome editing, no double-strand break (DSB). Although a DSB in DNA is the usual result when the CRISPR/Cas9 genome-editing system is used, modified versions of CRISPR/Cas9 avoid cutting into the genome and instead manipulate the epigenome. Rather than change genes — and risk introducing potentially harmful mutations — epigenome-targeting CRISPR/Cas9 systems change gene expression. More

Highly Efficient Flavin-Adenine Dinucleotide Glucose Dehydrogenase Fused to a Minimal Cytochrome C Domain
Journal of the American Chemical Society Share

Flavin–adenine dinucleotide (FAD) dependent glucose dehydrogenase (GDH) is a thermostable, oxygen insensitive redox enzyme used in bioelectrochemical applications. The FAD cofactor of the enzyme is buried within the proteinaceous matrix of the enzyme, which makes it almost unreachable for a direct communication with an electrode. In this study, FAD dependent glucose dehydrogenase was fused to a natural minimal cytochrome domain in its c-terminus to achieve direct electron transfer. More

Can Young Stem Cells Make Older People Stronger?
The Scientist Share

Can one grow old without growing frail? One company is banking on the idea that with the right treatment, the answer can be "yes" for many more people. In clinical trials published in October in the Journals of Gerontology, Longeveron, the firm developing the therapy, reports that a single infusion of mesenchymal stem cells from younger donors had no apparent safety downsides for people with aging-related frailty — and spurred improvement in many of their symptoms. More

Disease Caused by Reduction of Most Abundant Cellular Protein Identified
Bioscience Technology Share

An international team of scientists and doctors has identified a new disease that results in low levels of a common protein found inside our cells. The study, led by Siddharth Banka from The University of Manchester and the Manchester Centre for Genomic Medicine, St Mary's Hospital, is published in the American Journal of Human Genetics. β-actin is the cell's most abundant protein, providing shape and allowing them to move. It is fundamental to a number of biological functions. More

Career

Automation Scientist
Recursion Pharmaceuticals
US – UT – Salt Lake City

Manager, Production Chemistry
Wacker
US – MI – Adrian

Assistant Professor in Nuclear Medicinal Chemistry
Simon Fraser University
CA – BC – Burnaby

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