This message contains images. If you don't see images, click here to view.
Advertise in this news brief.



Advertisement


Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit December 14, 2016

SLAS.org    SLAS2017    Moving? New job? Let SLAS know.      

Advertisement

Advertisement

Advertisement

Advertisement

Advertisement








 


news

Turbocharged Artificial Intelligence: A Powerful New Digital Health Technology Can Optimize Combination Therapy in Pediatric Leukemia
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
A new report published ahead-of-print in SLAS Technology (formerly JALA) introduces a landmark advance in personalized and precision medicine from the University of California, Los Angeles (UCLA) — a powerful digital health platform named Phenotypic Personalized Medicine that can overcome the complex challenges of efficacy and toxicity in optimizing drug ratios in combination therapies for pediatric leukemia. This research is supported by SLAS, the National Cancer Institute, National Science Foundation, V Foundation for Cancer Research, Wallace H. Coulter Foundation and UCLA Children's Discovery and Innovation Institute Today's and Tomorrow's Children Fund Award and the endowment fund of the Ben Rich–Lockheed Martin Professorship.

SLAS members and SLAS Technology subscribers can read "Optimizing Combination Therapy for Acute Lymphoblastic Leukemia Using a Phenotypic Personalized Medicine Digital Health Platform: Retrospective Optimization Individualizes Patient Regimens to Maximize Efficacy and Safety" now.
More


Advertisement


SLAS2017 Advance Registration Discounts Available Through Dec. 19
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
SLAS2017 features an extensive lineup of education, information and practitioner-selected programming for life sciences discovery and technology professionals. With 140 podium presentations, 21 Short Courses, 16 Special Interest Groups and two high-profile keynotes offered, build your personalized agenda using the SLAS2017 Event Scheduler today.

Registration discounts up to $210 are available if you register by this Monday, Dec. 19. Substantial discounts also are available for student attendees and groups. Additionally, SLAS offers complimentary registration to individuals currently unemployed — download the waiver request form.
More


Advertisement
Sponsored Content


SLAS Europe Compound Management Conference 2017 Call for Presentation Abstracts
SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
Due Thursday, Dec. 15! Themed Breaking Down Walls — Uniting Sample Management Communities to Advance Scientific Innovation, the conference is set for March 14-15 in Berlin, Germany. Effective design and management of compound collections is crucial to the success of research efforts in the pharmaceutical, biotechnology and agriscience areas.

In addition, academic organizations are establishing comprehensive compound management infrastructures to help realize their target validation and drug discovery goals. This SLAS Europe conference provides fresh perspectives and innovative solutions to compound management and lead discovery professionals, from bench scientists to senior leaders.
More




Advertisement
Accelerate your NGS Success

Fast, accurate sequencing begins with automated NGS Sample Prep from Agilent.


SLAS ELN Reports: Remedy for Reproducibility — Opening a Dialog to Explore the Complexities
SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists have contemplated the importance of validating research for decades. At each point along the path toward publication of preclinical research, there are both checkpoints for accuracy and challenges to proving what has been discovered.

SLAS2017 offers a panel of perspectives that include a watchdog, a publisher, a funder and scientists from industry and academia to expand the current search for answers as to who in the pipeline is responsible for making certain that published research is accurate and stands a good chance of delivering over time. Read about this challenging task in the SLAS Electronic Laboratory Neighborhood e-zine.
More


Sign Up Now for an SLAS2017 Mentoring Session
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Free one-on-one mentoring and career counseling is offered to all SLAS2017 registrants on a first-come, first-served basis, so sign up today using a simple online form.

Volunteer mentors come from academia, industry and government to share their stories and answer questions during private, 45-minute sessions on Monday and Tuesday, Feb. 6-7.
More


Advertisement


SLAS Journals Invite Special Collection Proposals
SLAS     Share    Share on FacebookTwitterShare on LinkedinE-mail article
SLAS Discovery and SLAS Technology invite proposals from interested guest editors for collections of five to seven original scientific reports that collectively explore the different dimensions, recent achievements and existing challenges related to a timely topic of interest and importance to SLAS journal readers. Special collections published recently include: Learn about how you can contribute as guest editor and work closely with the journal editor-in-chief. More


SLAS2017 Short Course Spotlight: Pharmacology in Drug Discovery and Development —- New Lives for Receptors as Drug Targets Through Allostery and Biased Signaling
SLAS    Share    Share on FacebookTwitterShare on LinkedinE-mail article
This course discusses new ideas about efficacy (efficacy fingerprints, biased signaling) and allosteric receptor function to improve definition and quantification of GPCR drug activity, better target drug activity (i.e. pathway vs. target validation) and predict therapeutic activity profiles. Specifically, methods to guide SAR for biased signaling and allosteric ligand activity are featured.

Course instructor is Terry Kenakin, Ph.D., University of North Carolina School of Medicine and author of 10 books on pharmacology. Pharmacology in Drug Discovery and Development: New Lives for Receptors as Drug Targets Through Allostery and Biased Signaling is one of 21 Short Courses to be held at SLAS2017.
More


Advertisement
Sponsored Content

news


Anti-CRISPR Protein Is Gene Editing 'Off-Switch'
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at the UMass Medical School and the University of Toronto say they have discovered the first known "off-switches" for CRISPR/Cas9 activity, providing much greater control over the edits, according to a new study published in Cell. Erik J. Sontheimer, Ph.D., professor in the RNA Therapeutics Institute at UMass Medical School, along with Alan Davidson, Ph.D., professor of molecular genetics, and Karen Maxwell, Ph.D., assistant professor of biochemistry, at the University of Toronto, identified three naturally occurring proteins that inhibit the Cas9 enzyme. More


Medical Innovation Bill Sails Through Congress
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
In one of their last moves of the year, U.S. lawmakers in the House of Representatives and the Senate cleared legislation designed to boost medical innovation and stem the growing opioid abuse crisis. The 21st Century Cures Act (H.R. 34) now heads to President Obama, who is expected to sign the bill into law. The bipartisan legislation authorizes $6.3 billion over 10 years to be funneled to the National Institutes of Health, the Food & Drug Administration, and states. More


Advertisement


Sample Preparation for Bioanalytical and Pharmaceutical Analysis
Analytical Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Biological and pharmaceutical samples represent formidable challenges in sample preparation that hold important consequences for bioanalysis and genotoxic impurity quantification. This feature will emphasize significant advances toward the development of rapid, sensitive, and selective sample preparation methods. More


Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin
Journal of the American Chemical Society    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The biosynthesis of the thiopeptide thiomuracin is a well-orchestrated process involving a multitude of posttranslational modifications. We show that six Cys residues of a precursor peptide are first cyclodehydrated and oxidized to thiazoles in an ordered, but nonlinear fashion that is leader-peptide-dependent. Then four alcohols are glutamylated and converted to alkenes in a C-to-N terminal directional process that is leader-peptide-independent. More


Advertisement
Digilab Identity Raman Plate Reader

Digilab has combined advancements in the miniaturization of spectrometers, data storage, robotics & automation, to develop the Digilab Identity Raman Plate Reader, enabling fast sample measurement into microtiter plates or slides, with the flexibility of low-to-high throughput for many industry specific applications. Why settle for less with your research investment?
Advertisement
KMC Systems Engineering & Manufacturing
KMC Systems provides contract engineering and manufacturing services to leading and emerging OEMs. As a trusted outsourcing partner for 35 years, KMC Systems develops, designs and manufactures cutting-edge, full-system instrumentation for the medical and life science markets. Visit us online and download our brochure to learn more about KMC Systems.
Advertisement
Specialized Lab-on-a-Chip solutions
Micronit creates added value for our customers by offering a unique combination of:
1. Microfluidics expertise from design through prototyping to manufacturing.
2. Materials, from glass to polymers, silicon or hybrid combinations.
3. Customer application know-how, which together enable our customers to develop winning products, both now and in the future.


Chemists Uncover a Means to Control Catalytic Reactions
Phys.org    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at the University of Toronto have found a way to make catalysis — the use of catalysts to facilitate chemical reactions — more selective, breaking one chemical bond 100 times faster than another. The findings are described in a study published in Nature Communications. The team of researchers, led by Nobel Prize-winning chemist John Polanyi, employed a combination of experiment and theory to discover that the position of the molecule on the catalytic surface is a key factor in determining the rate at which particular bonds break. More


Chemical Trickery Corrals 'Hyperactive' Metal-Oxide Cluster
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
After decades of eluding researchers because of chemical instability, key metal-oxide clusters have been isolated in water, a significant advance for growing the clusters with the impeccable control over atoms that's required to manufacture small features in electronic circuits. Oregon State University chemists created the aqueous cluster formation process. More




Career

Advance Registration: Dec. 19, 2016
Discounted Hotel Reservations: Jan. 5, 2017
Poster Submissions: Jan. 23, 2017


Career


Postdoctoral Fellow, Multi-Photon Imaging of Neocortex
Medical University of South Carolina
US – SC – Charleston

Senior Scientist, Discovery Oncology
Genentech
US – CA – South San Francisco

Staff Scientist
National Institute of Neurological Disorders and Stroke
US – MD – Bethesda

Search Jobs at SLAS Career Connections


news

 
SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
Download media kit

Dennis Hall, Executive Editor, 469.420.2656   
Contribute news

This edition of SLAS Point-to-Point was sent to ##Email##. To unsubscribe from receiving SLAS Point-to-Point, click here. To unsubscribe from all SLAS e-mail communications, please click here. Did someone forward this edition to you? Subscribe here — it's free!

SLAS Terms of Use Policy
Recent issues

Dec. 7, 2016
Nov. 30, 2016
Nov. 23, 2016
Nov. 16, 2016



7701 Las Colinas Ridge, Ste. 800, Irving, TX 75063