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Center Yourself: 2017 SLAS Annual Report
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At the center of today's many changes, challenges and choices are SLAS members, the principal stakeholders in the unique and united community of professionals who thrive at the intersection of applied and basic life sciences discovery and technology. "Relevant, collaborative and future-focused" describe SLAS in 2017. To the benefit of more than 18,000 community members worldwide, significant strides forward were made to enhance SLAS operations and the Society's resource-rich menu of programs, products, services and events.
Read more from SLAS CEO Vicki Loise in the SLAS Electronic Laboratory Neighborhood e-zine.
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New and FREE at SLAS Discovery: Bioluminescent High-Throughput Succinate Detection Method for Monitoring the Activity of JMJC Histone Demethylases and Fe(II)/2-Oxoglutarate-Dependent Dioxygenases
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A new (and freely available) original research article published ahead-of-print at SLAS Discovery Online describes a new methodology that enables the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily. This superfamily comprises approximately 60 enzymes that are responsible for regulating a wide number of biological processes including epigenetic regulation, DNA/RNA repair and oxygen sensing.
Of these, JumonjiC histone lysine demethylases (JMJCs) and prolyl hydroxylases are potential drug targets because of their relevance to human diseases. Image copyright Promega Corporation.
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SLAS2018 Hotel Reservation Deadline is Jan. 4
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Reservations made after Jan. 4 at the official SLAS2018 hotels — the Marriott Marquis San Diego Marina and Hilton San Diego Bayfront — will receive the group rate based only on individual hotel availability. Both hotels are already near capacity, so it's strongly recommended that you reserve your room ASAP.
Both hotels are conveniently adjacent to the San Diego Convention Center and offer strong, exclusive perks to those who reserve rooms through official booking channels. Be aware of bogus reservation scams; secure your reservations, discount rates and special amenities by booking through the SLAS2018 links.
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Groups that rely on Excel files to manage scientific data and communicate results run the risk of operating inefficiently, and their scientific innovation and new development candidates frequently suffer. With this free report, learn how viDA Therapeutics streamlined their processes and improved collaboration.
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Final SLAS2018 Poster Presentation Abstracts Due Jan. 22
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There still is time to share your work at SLAS2018! Present a poster at SLAS2018 to share your achievements and gather informed opinions from other experts in your field. The online submission form is quick and easy. If selected, step-by-step guidelines will help you complete your poster.
Posters are displayed during all open hours of the Exhibition, and poster authors are required to present their posters during assigned one-hour time periods.
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Grad Students and Postdocs: Build Your CV with Peer-Reviewed Publication
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Existing materials, such as the introductory section of a thesis, often can be shaped into successful review articles. Well-researched and well-written reviews are the most widely-read and most highly-cited articles published in SLAS journals and can help you heighten your online profile in PubMed, ORCID, Google Scholar, Kudos, SLAS and many other indexing services.
Become a recognized contributor to a prestigious international research community and submit an abstract to SLAS Discovery (Advancing Life Sciences R&D) or SLAS Technology (Translating Life Sciences Innovation) today.
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Latest SLAS Technical Webinar Available On Demand for Free
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"How AstraZeneca is Revolutionizing Sample Management with Acoustic Tube-based Technologies," the most recent offering in the SLAS Webinar series, is now available for on demand access for free to both SLAS members and non-members alike.
Recorded live on Dec. 12, this webinar addressed AstraZeneca's vision to enhance their sample management capabilities by standardizing on acoustic liquid handling throughout sample storage and screening preparation workflows.
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Share the SLAS Story
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Do you have colleagues who could benefit from the opportunities offered by membership in SLAS?
Tell them why you belong and share this link so they can learn first-hand how others have advanced their careers and enhanced their personal lives through SLAS and its programs.
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Titian, HighRes and Genedata's SLAS2018 tutorial 'Partnering to Close the Screening Loop' demonstrates a seamless workflow to support the iterative drug discovery life cycle of designing, planning, testing and analyzing. The approach effortlessly moves information to where it needs to be.
Register to receive this tutorial recording.
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Single-Stranded DNA and RNA Origami
Science Magazine Share
Nanostructures created by origami-like folding of nucleic acids are usually formed by base-pairing interactions between multiple strands. Han et al. show that large origami (up to 10,000 nucleotides for DNA and 6000 nucleotides for RNA) can be created in simple shapes, such as a rhombus or a heart. A single strand can be folded smoothly into structurally complex but knot-free structures by using partially complemented double-stranded DNA and the cohesion of parallel crossovers.
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Combining in Vitro and in Silico Single-Molecule Force Spectroscopy to Characterize and Tune Cellulosomal Scaffoldin Mechanics
Journal of the American Chemical Society Share
Cellulosomes are polyprotein machineries that efficiently degrade cellulosic material. Crucial to their function are scaffolds consisting of highly homologous cohesin domains, which serve a dual role by coordinating a multiplicity of enzymes as well as anchoring the microbe to its substrate. Here we combined two approaches to elucidate the mechanical properties of the main scaffold ScaA of Acetivibrio cellulolyticus.
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Virus-Like Synthetic Nucleocapsid Carries Own RNA Genome, Evolves
Genetic Engineering & Biotechnology News Share
It's a protective shell, very much like those used by viruses to package and ferry their genomes. This shell, however, is built from computer-designed proteins — which sounds fairly innocuous. Such a shell, should it be used to encapsulate a drug, might facilitate the drug's delivery. It's not anything that could advance research into artificial life. Or could it?
Well, it could, and here's why: The shell is a synthetic nucleocapsid that packages its own full-length messenger RNA (mRNA) genome.
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Low-Energy Electrons May Spark Some Space Chemistry
Chemical & Engineering News Share
When scientists think about what drives chemistry in space, high-energy radiation, such as X-rays, gamma rays and ions, gets most of the attention. But a new study suggests that low-energy electrons may actually do much of the heavy lifting when it comes to forming bonds and making compounds that could be precursors to complex organic molecules.
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Atoms Rearrange in Electrolyte and Control Ion Flow Under Tough Conditions
Phys.org Share
Minerals that make up rocks and soils are thrown out of equilibrium when the chemistry of their surroundings changes. Shifts in pH or the concentration of ions in water make minerals dissolve, grow or react in other ways. These reactions are influenced by the arrangement of atoms at the interface — where minerals and water touch. Historically, it has been hard to study these structures while reactions are proceeding because the interface is constantly changing.
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A New Theory to Describe Widely Used Material
Science Daily Share
One of the most commonly used materials in organic electronics is the conducting polymer PEDOT:PSS, and tens of thousands of scientific articles have been published referring to the material and its properties. One of the major advantages of PEDOT:PSS is that it conducts both ions and electrons, but a model that explains how this works has, until now, not been available. We know that the material has several useful properties, but we don't know why.
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After Searching 12 Years for Bipolar Disorder's Cause, Team Concludes It Has Many
Bioscience Technology Share
Nearly 6 million Americans have bipolar disorder, and most have probably wondered why. After more than a decade of studying over 1,100 of them in-depth, a University of Michigan team has an answer — or rather, seven answers.
In fact, they say, no one genetic change, or chemical imbalance, or life event, lies at the heart of every case of the mental health condition once known as manic depression.
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S&T is Enhancing the Autopsy Digital Forensics Tool
Lab Manager Share
Autopsy — an open-source, digital forensics platform used by law enforcement agencies worldwide to determine how a digital device was used in a crime and recover evidence — is being enhanced with the addition of several new capabilities requested by law enforcement. Nearly every crime committed today involves digital media — such as computers and cell phones.
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Automation Engineer – Next Generation Sequencing
PapGen Inc.
US – MA – Woburn
Automation Scientist
Recursion Pharmaceuticals
US – UT – Salt Lake City
Brain Imaging Postdoctoral Fellowship
Johns Hopkins
US – MD – Baltimore
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SLAS Point-to-Point
Colby Horton, Vice President of Publishing, 469.420.2601
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