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SLAS.org    SLAS2012   Moving? New job? Let SLAS know.    Dec. 21, 2011



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SLAS2012 short courses are filling up
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Thinking about taking an SLAS2012 short course Feb. 4 or Feb. 5? Sign up now, as each short course accommodates a limited number of attendees for maximum effectiveness, and many are reaching capacity. More

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JALA announces special issue call for papers
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Guest Editors Wen J. Li, Ph.D., and Ning Xi, Ph.D., of City University of Hong Kong, invite submissions on topics exploring robotics for laboratory automation. Abstracts are due Feb. 15, 2012. More



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SLAS2012 speaker Peter Schultz's work heralded
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The work of the Peter Schultz laboratory at Scripps Research Institute to insert an unnatural amino acid into proteins made by Escherichia coli by borrowing a synthetase and a tRNA from an archaea microbe is featured in Chemical & Engineering News Chemical Year in Review 2011. More

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Humans on a chip?
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"This new NIH DARPA challenge is to combine microfabrication techniques with modern tissue engineering to allow different populations of cells to connect, communicate and form a more complete physiological system that can better mimic the behavior of human organs,” says Dino Di Carlo, Ph.D. Read about it in a new SLAS Electronic Laboratory Neighborhood feature. More

JBS epigenetics special issue released
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The December 2011 issue, Epigenetic-Targeted Drug Discovery, Part I, is now available at JBS Online. Guest editors Tom Heightman, Astex Pharmaceuticals, and Andrew Pope, GlaxoSmithKline, say the issue features contributions from leading public sector, biotech and pharmaceutical groups who are applying 21st century drug discovery techniques to allow the generation and characterization of small molecule inhibitors of epigenetic regulatory proteins. More

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JALA scientific advisor joins PrimeraDx board
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PrimeraDx appointed Leroy Hood, M.D., Ph.D., of the Institute for Systems Biology and a global leader in the molecular device industry, to its Scientific Advisory Board. More

Thank you, Mark Herrmann!
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SLAS member Mark Herrmann, ARUP Laboratories, provided stunning photography for a recent SLAS Electronic Laboratory Neighborhood feature, "Bridging the Valley of Death: How Can Academia and Pharma Best Work Together?" More
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Cornell wins NYC Tech Campus bid
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New York Mayor Michael R. Bloomberg, Cornell University President David J. Skorton and Technion-Israel Institute of Technology President Peretz Lavie announced an historic partnership to build a two-million-square-foot applied science and engineering campus on Roosevelt Island in New York City. More

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Naked mole rats evolved to handle acid
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A new study explains why naked mole rats surprisingly feel no pain from acid. The findings, by scientists at the Max Delbrück Center for Molecular Medicine in Berlin, Germany, may prove useful in tackling human pain. Their results are published in this week's issue of Science. More

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US agencies collaborate to test 10,000 chemicals
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A high-speed robotic screening system jointly initiated by three key US health agencies began testing more than 10,000 chemical compounds for potential toxicity on Dec. 7. The National Institutes of Health, the Environmental Protection Agency and the Food and Drug Administration aim to improve how chemicals, including many consumer products, food additives and pharmaceuticals, are tested for safety. More

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A map of minor groove shape and electrostatic potential from hydroxyl radical cleavage patterns of DNA
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DNA shape variation and the associated variation in minor groove electrostatic potential are widely exploited by proteins for DNA recognition. Here we show that the hydroxyl radical cleavage pattern is a quantitative measure of DNA backbone solvent accessibility, minor groove width and minor groove electrostatic potential, at single nucleotide resolution. More

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A gene-fusion strategy for stoichiometric and co-localized expression of light-gated membrane proteins
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The precise co-localization and stoichiometric expression of two different light-gated membrane proteins can vastly improve the physiological usefulness of optogenetics for the modulation of cell excitability with light. Here we present a gene-fusion strategy for the stable 1:1 expression of any two microbial rhodopsins in a single polypeptide chain. More

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Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
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Antibiotic resistance can evolve through the sequential accumulation of multiple mutations. To study such gradual evolution, we developed a selection device, the "morbidostat," that continuously monitors bacterial growth and dynamically regulates drug concentrations, such that the evolving population is constantly challenged. More

Twist in the tail of eukaryotic origins
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Complex life may have had parasitic origins. New evidence suggests that the relatives of the mitochondria within our cells once had a tail, like many parasitic bacteria. Life on Earth is packaged into three domains: the simple bacteria, the archaea and the complex eukaryotes that make up most of the life we see with the naked eye. More



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Scientists uncover evidence on how drug-resistant tuberculosis cells form
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A new study led by Harvard School of Public researchers provides a novel explanation as to why some tuberculosis cells are inherently more difficult to treat with antibiotics. The discovery, which showed that the ways mycobacteria cells divide and grow determine their susceptibility to treatment with drugs, could lead to new avenues of drug development that better target tuberculosis cells. More

A full work-up for Alzheimer's disease
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Moving a step closer to increasing opportunities to diagnose Alzheimer's disease before memory loss occurs, the Cleveland Clinic's Lou Ruvo Center for Brain Health has been chosen by Paris-based Exonhit SA to conduct the first U.S. pilot clinical trial for AclarusDx, a blood-based investigational diagnostic test. More



Cockroach 'let's hook up' chemical signal could benefit endangered woodpecker
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A North Carolina State University discovery of the unique chemical composition of a cockroach signal — a "Let's hook up" sex pheromone emitted by certain female wood cockroaches to entice potential mates — could have far-ranging benefits, including improved conservation of an endangered woodpecker. More

Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase
Journal of Medicinal Chemistry    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. More


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Career

Associate Director, CMC Operations
Biotie Therapies
USA – CA – South San Francisco

DNA Assembly Process Lead
Ginkgo BioWorks
USA – MA – Boston

Clinical Laboratory Scientist Team Leader
Cedars-Sinai Medical Center
USA – CA – Los Angeles

More jobs at SLAS Career Connections


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