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Text version   RSS   Subscribe   Unsubscribe   Archive   Media Kit December 28, 2015

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Dear subscribers,
Last week's SLAS Point-to-Point experienced technical issues, causing many subscribers to not receive the publication. Because of several time-sensitive news items presented within the issue, we have opted to resend the Dec. 23 publication. We apologize for any inconvenience.

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SLAS Announces Global Leadership Changes for 2016
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The SLAS Board of Directors, SLAS Americas Council and SLAS Europe Council welcome new members early in 2016. Congratulations to:

SLAS Board of Directors
Peter Grandsard, Amgen (Thousand Oaks, CA)
Ian Shuttler, Tecan (Mannedorf, Switzerland)
Sabeth Verpoorte, University of Groningen (Groningen, The Netherlands)

SLAS Americas Council
Neal Cosby, Promega Corporation (Sunnyvale, CA)
Andrea Weston, Bristol-Myers Squibb (Wallingford, CT)

SLAS Europe Council
Philip Gribbon, Fraunhofer, (Hamburg, Germany)
Christian Parker, Novartis (Basel, Switzerland)


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Jan. 4 Last Chance to Win a $500 Amazon Gift Card
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The JALA & JBS Art of Science Contest celebrates those stunning scientific images — mesmerizing shapes, patterns and designs — that capture attention and imagination while also communicating scientific work. Applying is simple: submit your high-resolution file and a brief description of your image for a chance to win a $500 Amazon gift card. See last year's winners. More


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The Lab Man in SLAS ELN: Screening Strategies for Drug Discovery — Matching Tools with Solutions
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In The Lab Man's latest article in the SLAS Electronic Laboratory Neighborhood e-zine, SLAS2016 "Screening Strategies for Drug Discovery: Matching Tools with Solutions" Short Course instructors David Swinney of iRND3 (Mountain View, CA) and Jonathan Lee of Eli Lilly and Company (Indianapolis, IN) provide an insightful, experience-based perspective on the drug discovery process.

"The focus should always be on identification of medicines for the patients," Swinney says. "Phenotypic approaches and target-based approaches provide different strategies and tools in the drug discovery tool box. It is important to know what tools are available and know how to effectively use the tools, so that the appropriate tool is selected and used in an efficient manner."
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Presenters Announced for Late Night with LRIG at SLAS2016
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Eighteen companies have been selected to each make six-minute presentations to SLAS2016 attendees at Late Night with LRIG: Rapid-Fire Innovation Session, Monday, Jan. 25, 6:30-8:30 p.m. Plan time in your SLAS2016 schedule to learn about their new products and technology improvements at this popular evening forum. Beer and soft drinks are provided.

Session moderators are Andy Zaayenga of SmarterLab, Anne Kopf-Sill of eFluidics and Sanj Kumar of EuroDiagnostica.
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SLAS2016 Sneak Peek
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Use the SLAS2016 Event Scheduler to plan your personal agenda to make the most of your time at SLAS2016. Prioritize your choices from more than 130 scientific podium presentations, such as "Development of a Platform to Enable Fully Automated Cross-Titration Experiments" by Jason Cassaday of Merck (North Wales, PA).

Quantification of allostery is especially difficult for G-protein coupled receptors (GPCRs) given the coupling of ligand binding to down-stream effectors. Several mathematical models exist which can be employed to extract values that reflect allosteric potency and efficacy as well as intrinsic activity of agonist and modulator from a global fit of agonist shift data. Due to the nature of these experiments (cross-titrations of agonists and unknowns) the experiments grow exponentially in size compared to a standard dose titration. To enable implementation of these models across a large screening hit list, we employed expertise in robotics, information technology and assay development to design an automation platform capable of performing agonist shift assays in a high-density (1536 well), high-throughput format that can test hundreds of compounds per day in cross-titration experiments.

Cassaday presents Wednesday, Jan. 27 at 10:30 a.m.
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SLAS2016 Poster Abstracts Final Deadline is Jan. 11
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There's still time to share your recent achievements on the SLAS2016 global stage, Jan. 23-27, San Diego.

The SLAS2016 Program Committee is accepting poster abstracts for review and consideration from life sciences discovery and technology professionals at all career stages.

Poster presenters must be registered SLAS2016 participants.
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Happy Holidays from SLAS
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The leadership and professional teams of SLAS offer a heart-felt thank you for making us part of your world in 2015.

Happy holidays and best wishes for a new year full of transformative accomplishments, beginning at SLAS2016.
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Stopping Premature Protein Synthesis Halts Genetic Diseases
Genetic Engineering & Biotechnology News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Scientists at Cold Spring Harbor Laboratory report that they have inhibited a process cells have evolved to prevent imperfect proteins from being synthesized. Improperly formed proteins can cause a host of serious illnesses, from muscular dystrophy to cystic fibrosis. A question of enormous import in research, beyond the challenge of determining how malformed proteins contribute to specific disease processes, is figuring out ways to prevent or reduce the pathologies they cause. More


What Is an Adult Stem Cell?
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The paradigm of the hematopoietic stem cell (HSC) has become deeply engrained in our minds, ever since bone marrow transplantation technology narrowed in on this almost magical multipotent entity that gives rise to all blood cells. The HSC's ability to "self-renew" as well as to proceed down hierarchical differentiation pathways involves a rigidly choreographed flow of events. The HSC paradigm currently serves as a template to interpret experimental observations on any other mammalian tissue. More


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Simple Physical Mechanism for Assembly And Disassembly of Structures Inside Cells
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For the first time, scientists have demonstrated a simple charge-based mechanism for regulating the formation and dissolution of liquid-like structures that lack outer membranes inside cells. The research provides a first step in deciphering how these poorly-understood structures function in the cell and how they may have evolved. The research, conducted by Penn State University scientists, appears as an advance online publication of the journal Nature Chemistry. More


Success of Climate Deal Will Hinge on Chemistry
Chemical & Engineering News    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Chemists and other scientists are expected to play a key role as the world implements the new climate change deal that governments clinched in Paris on Dec. 12. The historic Paris pact includes commitments by 185 countries and the European Union to control emissions of carbon dioxide and other greenhouse gases. It signals a shift away from a world economy marked by unfettered release of carbon dioxide produced by burning fossil fuels. More


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Scientists Reveal Brain Circuit Mechanisms Underlying Arousal Regulation
Bioscience Technology    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Adjusting a specific deep-brain circuit's firing frequency immediately and dramatically alters rats' forebrain activity and alertness levels, Stanford University School of Medicine investigators have shown. The findings, published online Dec. 10 in eLife, hold direct implications for an increasingly widespread therapeutic approach called deep-brain stimulation. More


New Results from World's Most Sensitive Dark Matter Detector
Lab Manager    Share    Share on FacebookTwitterShare on LinkedinE-mail article
The Large Underground Xenon (LUX) dark matter experiment, which operates nearly a mile underground at the Sanford Underground Research Facility (SURF) in the Black Hills of South Dakota, has already proven itself to be the most sensitive detector in the hunt for dark matter, the unseen stuff believed to account for most of the matter in the universe. Now, a new set of calibration techniques employed by LUX scientists has again dramatically improved the detector's sensitivity. More




Mining the Mite-ochondrial Genome
The Scientist    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Some mite populations may be better suited to survive in the hair follicles of human hosts from certain geographic regions, according to a study published in PNAS. Michael Palopoli of Bowdoin College in Brunswick, Maine, and colleagues isolated Demodex folliculorum mite DNA from 70 people of diverse geographic ancestries, analyzing more than 200 sequences from the anthropod’s mitochondrial genome. More


Hybrid Material Presents Potential for 4-D-Printed Adaptive Devices
Science Daily    Share    Share on FacebookTwitterShare on LinkedinE-mail article
Combining photo-responsive fibers with thermo-responsive gels, researchers at the University of Pittsburgh's Swanson School of Engineering and Clemson University have modeled a new hybrid material that could reconfigure itself multiple times into different shapes when exposed to light and heat, allowing for the creation of devices that not only adapt to their environment, but also display distinctly different behavior in the presence of different stimuli. More


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