SLAS Point-to-Point

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December 31, 2019

SLAS wishes its members and the global life sciences discovery and technology community all the best for 2020! Enjoy this look back at the most-read SLAS Point-to-Point articles of 2019. We resume regular weekly publication on Jan. 8, 2019.

SLAS2020 Tony B. Academic Travel Award Winners Announced
SLAS
From Oct. 30: Fifty-three life sciences students from 12 countries have been announced as SLAS2020 Tony B. Academic Travel Award winners. These students, graduate students, post-doctoral researchers and junior faculty members receive travel stipends to attend SLAS2020 in San Diego where they will present their research. This year's winning posters included insightful research on deep learning, advances in early-stage drug discovery, cell and particle sorting in microfluidic systems and many other innovative entries.
VIEW FULL LIST OF WINNERS

Exclusive Access in SLAS Technology: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids, and Disease Modeling
SLAS
From Feb. 13: In the second of a two-part review on human iPS cell-derived patient tissues (HiPSCs), researchers explain how and why HiPSCs provide several advantages for drug discovery and - more importantly — provide a source of clinically relevant tissue. In addition, novel methods in which 3D cell culture systems (principally organoids) are now being used to provide insights into disease mechanisms are also discussed.
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New Special Issue from SLAS Discovery — Academic Screening Centers and Translational Drug Discovery Centers
SLAS
From Feb. 27: In the March issue of SLAS Discovery, 15 academic screening laboratories and translational drug discovery centers from eight different countries are spotlighted for their expert contributions to drug screening. Because of the diversity of these laboratories, the issue features a wide range of topics, from phenotypic profiling of cellular responses to novel assays and technologies that allow the screening of large collections of chemicals. Limited access is now available through mid-March.
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Access the Latest Special Issue from SLAS Discovery — Academic Screening Centers and Translational Drug Discovery Centers
SLAS
From March 6: Don't miss the current issue of SLAS Discovery featuring 15 academic screening laboratories and translational drug discovery centers from eight different countries highlighted for their expert contributions to drug screening. Because of the diversity of these labs, the issue features a wide range of topics, from phenotypic profiling of cellular responses to novel assays and technologies that allow the screening of large collections of chemicals. Access to the March issue is limited and will only be available through March 20.
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Corning Presents an SLAS Technology Special Collection on Advances in 3D and Organoid Cell Culture
SLAS
From Jan. 23: A new collection of reviews and original research in February’s SLAS Technology illustrate how new technologies and advanced cell culture are accelerating basic research, drug discovery and drug development. This special collection illustrates how the human iPS cells and 3D cell culture technology provide powerful approaches to the development of novel and more effective therapies.This issue, sponsored by Corning Life Sciences, is free to access and includes:

Editorial Introduction: Convergence of Three-Dimensional Cell Culture and Human iPS Cells: Improving Clinical Relevance in Drug Discovery by Guest Editor Richard M. Eglen, Ph.D., Corning Life Sciences (Tewksbury, MA, USA)
Review Article: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 1: Target Identification and Lead Optimization
Review Article: Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids and Disease Modeling
Original Research: Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy
Original Research: Full Factorial Microfluidic Designs and Devices for Parallelizing Human Pluripotent Stem Cell Differentiation
Original Research: A Single-Step Self-Assembly Approach for the Fabrication of Aligned and Multilayered Three-Dimensional Tissue Constructs Using Multidomain Peptide Hydrogel

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SPONSORED VIDEO

inSPIRE your science
Promoted by Thermo Scientific

The Thermo Scientific™ inSPIRE™ collaborative system brings interactive, configurable solutions to the lab to automate your research. Learn how our unique touch-enabled technology and modular design is delivering inSPIREd science.

New from SLAS Technology — The SLAS Technology Ten
SLAS
From Jan. 30: The SLAS Technology Ten is out. This annual list showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Technology in the past 12 months and highlights a number of areas that are recognized as important emerging technologies for life sciences laboratories and the clinic. Featured topics include technology that automates and improves isolation of subsets of cells with applications ranging from liquid biopsies to cell therapy manufacturing, technologies that improve isolation and propagation of desired cells, improvements in ways to analyze these cells through both improved hardware and software solutions and improved automation approaches for a wide range of assays with implications for everything from drug development to forensic science. ACCESS SLAS TECHNOLOGY TEN

The First Infection Diagnostic Emerges From Carb-X
Chemical & Engineering News
From Oct. 2: A tool that can identify infections within hours is the first diagnostic product to emerge from the Carb-X partnership and could be the first of its kind to market. T2 Biosystems, based in Lexington, Massachusetts, created the diagnostic, called the T2 Resistance Panel. It relies on nuclear magnetic resonance to identify pathogens in the bloodstream.

Hot Off the Presses: New Auto-Commentary Available from SLAS Technology
SLAS
From March 6: For a limited time, get exclusive access to research and findings from the article, "Analytical Measurements and Efficient Process Generation Using a Dual-Arm Robot Equipped with Electronic Pipettes," straight from the authors. Read what they have to say about their novel integration of electronic piston pipettes into an automation system using a dual-arm robot to perform liquid handling tasks similar to human operators. Free access will be available through April 25.
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Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers
Journal of the American Chemical Society
From March 6: Modulation of protein–protein interactions by small molecules has emerged as a valuable approach in drug discovery. Compared to direct inhibition, PPI stabilization is vastly underexplored but has strong advantages, including the ability to gain selectivity by targeting an interface formed only upon association of proteins. Here, we present the application of a site-directed screening technique based on disulfide trapping to select for fragments that enhance the affinity between protein partners.

Is SaaS LIMS Right for Your Laboratory?
Lab Manager
Software as a Service is a term that is not only in vogue now, but every indication is that SaaS applications are here to stay. It wasn't that long ago that a SaaS application model was met with a high degree of skepticism, and rightly so. A few decades ago, network reliability was at best questionable, and companies demanding fast and high availability of data on distant servers were few and far between.