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| July 25, 2016 |
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American Journal of Transplantation (login required)
The immunological role of exosomes in allograft rejection remains unknown. We sought to determine whether exosomes are induced during lung allograft rejection and to define the antigenic compositions of HLA, lung-associated self-antigens (SAgs) and microRNAs (miRNAs). Exosomes were isolated from sera and bronchoalveolar lavage fluid from 30 lung transplant recipients (LTxRs) who were stable or who had acute rejection (AR) or bronchiolitis obliterans syndrome (BOS). Exosomes were defined by flow cytometry for CD63 and western blotting for annexin V SAgs, collagen V (Col-V) and Kα1 tubulin were examined by electron microscopy; miRNAs were profiled by a miRNA array. Donor HLA and SAgs were detected on exosomes from LTxRs with AR and BOS but not from stable LTxRs.
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ASTS
Regular registration rates for the 7th Annual ASTS Leadership Development Program are in effect through August 11, when increased late rates will apply. We hope you'll join us September 11-14, 2016, for this one-of-a-kind course!
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ASTS
The Cureus Journal of Medical Science and Donate Life America, with sponsorship from Novartis Pharmaceuticals Corporation, have announced a publishing competition aimed at optimizing organ donation and utilization rates. Submissions are due August 2, 2016.
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ASTS
The Foundation of the American Society of Transplant Surgeons has partnered with Amazon Smile. Just start your shopping here and the ASTS Foundation will automatically receive 0.5 percent of the price of your eligible Amazon Smile purchases.
American Journal of Transplantation
Liver transplantation has been established as the optimal therapy for patients with advanced end-stage liver disease (ESLD). Effective pretransplant ESLD care, however, includes a continuum of services, including the management of hepatic encephalopathy, portal hypertension and hepatocellular carcinoma. Unfortunately, access to advanced liver care and transplantation remains highly variable across population subgroups and geography. Patients living in rural areas or who have lower socioeconomic status (SES) are less likely to be listed for and to receive liver transplants than urban residents or higher SES patients with similar severity of illness. This is due, in part, to the limited availability of subspecialty gastroenterology care in many communities.
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Liver Transplantation
Identifying which liver transplantation (LT) candidates with severe kidney injury will have a full recovery of renal function after liver transplantation alone (LTA) is difficult. Avoiding unnecessary simultaneous liver-kidney transplantation (SLKT) can optimize the use of scarce kidney grafts. Incorrect predictions of spontaneous renal recovery after LTA can lead to increased morbidity and mortality.
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Medical Xpress
A new technique developed by a UBC researcher could make tissue regeneration cheaper and safer for healthcare systems and their patients. A study, conducted by UBC researcher Keekyoung Kim while at Harvard University, has identified new ways in which proteins and various biological molecules — known as growth factors — can work together to turn cells on the surface into cells that form the middle layer of the heart valve.
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By Chelsea Adams
 University of Chicago researchers think the garden of microbes that live on human skin and in the digestive system help determine whether a transplanted organ will be accepted or rejected by the body. Their research was published in The Journal of Clinical Investigation. In the study, mice treated with antibiotics before a skin graft survived twice as long as mice who didn't receive the medicine. Mice who were raised in a sterile environment also survived longer following a skin graft.
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Clinical Transplantation
Frail patients are more vulnerable to perioperative stressors of liver transplantation. Program Specific Reports, used in transplant center auditing, risk-adjust for frailty using the Karnofsky Performance Status (KPS) scale. We evaluate the extent to which functional impairment/disability is associated with increased risk of postoperative death.
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Medical Xpress
There's a nationwide shortage of suitable organs for transplanting — but what if some of those organs deemed "unsuitable" could be rejuvenated? Researchers at Addenbrooke's Hospital have managed just that — and last year gave two patients an unexpected Christmas present. In a room in the Department of Surgery, a kidney sits inside a chamber connected to tubes and monitors. Solutions and gases are pumping through it and urine is coming out.
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