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| November 14, 2016 |
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American Journal of Transplantation (login required)
The impact of allograft injury time of onset on the risk of chronic lung allograft dysfunction remains unknown. We hypothesized that episodes of late-onset (≥6 months) allograft injury would produce an augmented CXCR3/ligand immune response, leading to increased CLAD. In a retrospective single-center study, 1894 transbronchial biopsy samples from 441 lung transplant recipients were reviewed for the presence of acute rejection, lymphocytic bronchiolitis, diffuse alveolar damage, and organizing pneumonia.
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ASTS
Submissions for ASTS Research Grants will be accepted until Nov. 22, 2016.
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ASTS
Join us Jan. 26-29, 2017, for the 17th Annual ASTS State of the Art Winter Symposium as we explore the theme "Organ Donation 2.0: Turning Ideas into Action." Early bird registration rates are in effect until Dec. 1, and housing is filling quickly.
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ASTS
Invoices for 2017 member dues have been sent. If you did not receive the email, please let us know at asts@asts.org. If you are not a dual member, you can pay your open balance by logging into the Member Portal of ASTS.org. If you haven't logged in since August 22, your password has been reset and your username is now your email. Please use the "forgot password" link to reset your password.
American Journal of Transplantation
This article is a review of the salient points and a future prospective based on the 2014 Organ Procurement and Transplantation Network (OPTN)/Scientific Registry of Transplant Recipients (SRTR) liver donation and transplantation data report recently published by the American Journal of Transplantation.
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Sanofi Genzyme supports physicians in solid organ transplant through:
• Ongoing support of major professional societies
• Medical education
• Fellows conferences
• Professional education for community physician groups
We are investing in the present and future of transplantation
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News Medical
Researchers at the University of Michigan have transplanted lab-grown mini lungs into immunosuppressed mice where the structures were able to survive, grow and mature.
"In many ways, the transplanted mini lungs were indistinguishable from human adult tissue," says senior study author Jason Spence, Ph.D., associate professor in the Department of Internal Medicine and the Department of Cell and Developmental Biology at the U-M Medical School.
The findings were published in eLife and described by authors as a potential new tool to study lung disease.
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Transplantation (login required)
Whilst causes of hepatic artery thrombosis (HAT) after liver transplantation (LT) are multifactorial, early HAT (E-HAT) remains pertinent complication impacting on graft and patient survival. Currently there is no screening tool that would identify patients with increased risk of developing E-HAT. Researchers analyzed the native procoagulant state of LT recipients, identified through pretransplant thromboelastographic (TEG) data among other known risk factors, to identify risk factors for E-HAT.
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Medicine, Health Care and Philosophy
A provocative question has emerged since the Supreme Court of Canada’s decision on assisted dying: Should Canadians who request, and are granted, an assisted death be considered a legitimate source of transplantable organs? A related question is addressed in this paper: is controlled organ donation after assisted death (cDAD) more or less ethically-problematic than standard, controlled organ donation after circulatory determination of death (cDCDD)?
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Medscape
In times of a shortage of donor organs, long-term success and outcome of deceased donor renal transplantation gain crucial importance. The Eurotransplant Kidney Allocation System was first introduced in 1996 and thereafter continuously refined to improve patient and graft survival, guarantee objective recipient selection system based on medical and immunological criteria and streamline the use of available donor organs. The allocation is based on histocompatibility, waiting time, sensitization, logistic aspects and medical urgency. Patients waiting for a kidney graft can be granted high medical urgency status on condition that distinct criteria are fulfilled.
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Clinical Transplantation (login required)
Chronic hepatitis C infection is associated with a significantly increased post-transplant mortality in heart transplant recipients. The introduction of new direct-acting antiviral agents may provide a treatment option for HCV pre- or post-heart transplantation which could have a positive impact on patients' survival.
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