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Natural ion channel acts as 'brake' against spontaneous pain
Labmate Online
Many sensory neurons that detect pain in the body have been found to contain a channel that effectively acts as a form of 'brake', helping to limit spontaneous pain. Scientists have identified the channel that serves to stop people feeling some spontaneous pain and hope that the find will help with future developments in pain relief treatments.
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IN THE NEWS


Short circuit in ion channel amplifies pain
Genetic Engineering & Biotechnology News
Sensory neurons rely on molecular switches, ion channels, to detect extreme cold or heat, mechanical pressure, or harmful chemicals. When a channel opens, admitting the passage of a cation such as Na+, an electrical signal is created and transmitted to the brain. There, the signal is interpreted as pain. This pain pathway, despite its essential service as alarm signal, has a newly discovered flaw: It leaks.
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How nerve impulse generators get where they need to go
Ohio State University
Scientists have solved a longstanding mystery of the central nervous system, showing how a key protein gets to the right spot to launch electrical impulses that enable communication of nerve signals to and from the brain. This new research reveals a part of the process that was not understood before, about how a "molecular motor" helps move the impulse generator to its proper place on an axon to perform this vital job.
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How the 'Matthew Effect' helps some scientific papers gain popularity
MIT News
Do scientific papers written by well-known scholars get more attention than they otherwise would receive because of their authors' high profiles? A new study co-authored by an MIT economist reports that high-status authorship does increase how frequently papers are cited in the life sciences — but finds some subtle twists in how this happens.
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Scientists identify key to body's use of free calcium
Phys.org
Scientists at Johns Hopkins report they have figured out a key step in how "free" calcium — the kind not contained in bones — is managed in the body, a finding that could aid in the development of new treatments for a variety of neurological disorders that include Parkinson's disease.
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DISTRIBUTION PARTNER HIGHLIGHT

HEKA Elektronik serves worldwide markets either direct, through exclusive distributor partnerships, or in collaboration with resellers. Go to the HEKA Worldwide page to find the contact closest to you. We are pleased to announce the latest addition to our global network of distribution partners, Eisenberg Bros. Ltd in Israel.

Eisenberg Bros is a leading supplier of products and equipment for microscopy, electrophysiology, optics and electro-optics, biotechnology, nanotechnology, analytical research and nondestructive testing. Eisenberg Bros is the exclusive Israeli representative for the world's highest quality manufacturers and places a strong emphasis on first-class customer service and support.

The electrophysiology team in the microscopy department are experts in the scientific field and offer a comprehensive solution for your electrophysiology and imaging application. Among the companies Eisenberg Bros. represents are many of the most established names, like Olympus, Sutter Instruments, ALA scientific, Mightex, Stoelting and HEKA Elektronik.

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What do Biophysics 2014 and Jeff Goldblum have in common?

If you're watching Jeff Goldblum on the case as Detective Zach Nichols in Law & Order: Criminal Intent, you might be watching him blow your mind on the ION Television channel.

But during Biophysics 2014, HEKA will be discussing the other ion channels. We'll teach you how to record what happens when the ion channel is drugged and determine how to efficiently analyze the recordings.

Join us at the Heka Electrophysiology Update during Biophysics 2014 on Feb. 17. Register at heka.eventbrite.com.




When executing a PGF sequence in Current Clamp Mode, Patchmaster complains: "Segment voltage is too large, maximum is: 1.028nA". What does it mean?

The Current Clamp Gain for an EPC 10 amplifier is by default set to 0.1 pA/mV. This means a maximum current of 1 nA can be injected into the cell. If you need more, you can set the Current Clamp Gain either to "1", "10" or "100 pA/mV" in the Amplifier Window. This drop-down control is located on the Show All Tab of the amplifier Control Window. To prevent unintended large current injections, which could damage the cell, the CC Gain can only be changed in one of the voltage clamp modes. Further instructions can be found in the Patchmaster reference manual chapter 7.1.21.



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For over forty years HEKA has designed and manufactured sophisticated instrumentation and software for biomedical and Industrial research applications. The one constant that has remained the same is our commitment, to bring innovative technology to our most important business partner, our customer. HEKA is a select group of electrical engineers, biomedical researchers, and computer scientists who pride themselves on the quality of HEKA products and customer support.

That last part is key: customer support. Without the dedication you've shown to us over the years, HEKA wouldn't have been able to develop and create the products that you trust. Please feel free to let the experimental biology community know how you feel about HEKA Elektronik.


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