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Vasculata
Have you ever considered hosting Vasculata at your institution? Vasculata is a means by which NAVBO recruits the best and the brightest to the vascular biology community. It is an intense four-day course introducing the basics of cardiovascular biology in context with cutting edge science. If you are interested in organizing an upcoming Vasculata, including the 2016 presentation, please review our proposal form (it contains a lot of information about the criteria, etc.). The submission deadline for the 2016 presentation is February 20, 2015.
Some reminders for you: the minutes from the 2014 Member Business Meeting are available online. Go to www.navbo.org/BusMtg2014; we still have 20th Anniversary Tee shirts available - use the online membership application to order a tee shirt: http://www.navbo.org/membership/join-navbo
Remember to renew your membership for 2015 - www.navbo.org/membership/renew
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NAVBO - Serving the Vascular Biology Community for Twenty Years!
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This is our last installment of the Advances in Vascular Biology. We look forward to new innovations in the field in our next twenty years!
Advances in Vascular Biology - Leukocyte Adhesion Cascade
Contributed by Klaus Ley, La Jolla Institute for Allergy and Immunology
In the 1980s, researchers began to realize that leukocytes in inflamed blood vessels cannot stop on the spot, but must first adhere and roll along the vascular endothelium prior to extravasation. This cellular behavior was later shown to occur in a reconstituted system using a parallel plate flow chamber and by intravital microscopy, resulting in the formal proposal of the leukocyte adhesion cascade. The concept of the leukocyte adhesion cascade has stood the test of time and was refined by the work of many investigators, totaling 774 papers as of 19 May 2014.
Full list of references on our web site at http://www.navbo.org/20years/advances/leukocyte-adhesion-cascade
Vasculata 2015
Registration, abstracts and scholarship applications can now be submitted online. Go to www.navbo.org/vasculata15.
August 3-6, 2015 in Charlottesville, VA. Organized by Gary K. Owens.
Vascular Biology 2015
October 18-22 in Hyannis, MA. New feature — a pre-conference meeting developed by and for trainees. The preliminary program is available on the web site at www.navbo.org/vb2015. Registration and abstract submission will open later this month.
Welcome our newest Corporate Partner - Lonza.
See all of our corporate members at www.navbo.org/support/CorpMbrs
Travel Awards
Cure HHT will be granting Travel Awards for twenty-two (22) abstract presenters to attend the 11th International HHT Scientific Conference. Interested investigators should indicate their desire to be considered for a Travel Award on the Abstract Submission Form.
- Eighteen (18) Travel Awards will be provided to early stage investigators (who are within 3 years of completing their terminal research degree or within 3 years of completing their medical residency/sub-specialty fellowship at the time of abstract submission), residents, postdoctoral/clinical fellows, or PhD candidates are eligible for Travel Awards.
- Four (4) Travel Awards will be provided to individuals from the fields of nursing or genetic counseling.
The 11th International HHT Scientific Conference is being held June 11-14, 2015 in Captiva Island, Florida at the South Seas Island Resort. Abstract submission deadline is February 10, 2015. Information about the meeting is available at http://hhtconference.curehht.org/
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RECENT PUBLICATIONS BY NAVBO MEMBERS |
The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis
Journal of Lipid Research
Perlecan is a major heparan sulfate (HS) proteoglycan in the arterial wall. Previous studies have linked it to atherosclerosis. Perlecan contains a core protein and three HS side chains. Its core protein has five domains (I-V) with disparate structures and domain II is highly homologous to the ligand-binding portion of low-density lipoprotein receptor (LDLR).
VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
Development
The vascular endothelial growth factor (VEGFA, VEGF) regulates neurovascular patterning. Alternative splicing of the Vefga gene gives rise to three major isoforms termed VEGF121, VEGF165 and VEGF189. VEGF165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF121 cannot activate NRP1-dependent neuronal responses.
The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling
Developmental Cell
Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. The authors show that constitutive endothelial deletion of ERG (ErgcEC-KO) in mice causes embryonic lethality with vascular defects.
Be sure to share your electronic publications with your NAVBO colleagues. Go to www.navbo.org/epubs to submit any recent publication.
Editorial: Old dog, new tricks: proangiogenic effect of adenosine via stimulation of thrombospondin-1 in macrophages
Journal of Leukocyte Biology
Almost one century after the original observation of Drury and Szent-Gyorgyi, that it exerts cardiovascular effects, adenosine remains a subject of intensive studies, not only in the cardiovascular system but in many other areas of biology and medicine.
Blood vessel lining cells control metastasis
Cancer Cell
NAVBO member, Hellmut Augustin and other scientists from the German Cancer Research Center in Heidelberg and from the Medical Faculty Mannheim of Heidelberg University paved the way for an innovative combination therapy against metastases: They treated mice with a combination of a low-dose metronomic chemotherapy and an antibody against Ang-2, a regulatory protein of the blood vessel lining cells. The treated animals had significantly less metastases.
| Date |
Event |
More Information |
| Jan. 27 - Feb. 1, 2015 |
Mitochondria, Metabolism and Heart Failure joint with Diabetes and Metabolic Dysfunction |
Register
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| Feb. 8-12, 2015 |
Cardiology Update 2015 |
Register
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| Feb. 9-13, 2015 |
Systems Biology of Lipid Metabolism |
Register
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| Feb. 22-27, 2015 |
Hematopoiesis |
Register
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| June 11-14, 2015 |
11th International HHT Scientific Conference |
Register
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| June 21-26, 2015 |
The Atherosclerosis Gordon Research Conference |
Register
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For more meetings of interest go to the NAVBO Calendar of Events.
For a complete list of job postings, click here.
Have a job to post? Click here.
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NAVBO NewsBEAT
Colby Horton, Vice President of Publishing, 469.420.2601
Download media kit
Jessica Taylor, Senior Medical Editor, 202.684.7169
Contribute news
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Since 1994, the North American Vascular Biology Organization (NAVBO) has provided a forum for vascular biologists who are either in the traditional basic science disciplines (structural/molecular biology, cell biology, physiology) or studying the pathogenesis and treatment of human disease in disciplines such as medicine, pathology, surgery. NAVBO's membership is a mixture of scientists with different backgrounds and thus inherently different viewpoints on the same scientific problems. This makes for lively discussions and mutual education at our meetings and workshops. NAVBO provides the opportunity to communicate with a diverse cross-section of colleagues enhancing this discovery process, which will facilitate rapid translation into practical remedies.
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Recent issues
Jan. 1, 2015
Dec. 18, 2014
Dec. 4, 2014
Nov. 6, 2014
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