This message contains images. If you don't see images, click here to view.
Click
here to advertise in this news brief.
|
|
|
|
|
NAVBO - Serving the Vascular Biology Community for Twenty Years!
|
Don't forget to vote for your favorite T-shirt Design!!
Go to www.navbo.org/TshirtBallot
Voting ends June 30, 2014
Vasculata 2014 - July 14-17, in Seattle, Washington
REGISTER NOW - workshops are still open but campus housing is almost completely booked
www.navbo.org/vasculata
Vascular Biology 2014 - October 19-23, in Pacific Grove, California on the Monterey Peninsula
www.navbo.org/vb2014
Abstract deadine is August 1. The abstracts will be published in the October issue of Angiogenesis, which will be distributed at the meeting.
Current/active members receive a special 20th Anniversary savings - $20 off the early bird rate (expires August 15) - go to www.navbo.org/RegisterVB2014
Please welcome the following new members to NAVBO (joined since June 4)
Ali Ansari, University of Illinois at Urbana-Champaign
Tyler Cutforth, University of California, Irvine
Paniz Davari, University of Calgary
Andrew Dudley, UNC Chapel Hill
Jill Kuwarbara, University of Hawaii John A. Burns School of Medicine
Spencer Mamer, University of Illinois at Urbana-Champaign
Venkateswaran Subramanian, University of Kentucky
Jared Weddell, University of Illinois at Urbana-Champaign
Bing Zhang, Children's Hospital Boston
NAVBO’s Summer Course Helps Lay the Groundwork for Your Career in Vascular Biology
Vasculata is an intense four-day course introducing the basics of cardiovascular biology in context with the cutting edge of the impact of new
approaches to our ability to treat the most common causes of human disease in our society.
Vasculata combines seminars, a self- teaching program and workshops to provide attendees with a unique learning experience in a field not wholly covered in text books. The self-teaching program, called the VASCULATA WORKSHEET, provides a resource we expect attendees will continue to find valuable throughout their career.
Highlights of VASCULATA 2014 include an emphasis on stem cells and developmental biology; workshops on practical topics (imaging of the coronary vasculature in mice, MRI imaging of grafts and stem cells, differentiation and characterization of stem cell-derived cardiomyocytes, the zebrafish as a model system of cardiac development, and engineering vascular networks); joint sessions on Thursday (co-sponsored by NAVBO and the Society for Developmental Biology). There will be ample time for interactions with faculty, including NIH staff. Other opportunities include discussion sessions, poster sessions and a BBQ on Wednesday on the shores of Seattle’s Lake Union. View the program at http://www.navbo.org/events/vasculata2014/program
Students (graduate and undergraduate) and postdocs are encouraged to attend – but all are welcome to attend. Registration fees and housing costs are extremely affordable. See all meeting information at www.navbo.org/vasculata
This month we are highlighting the lab of Dr. Manfred Boehm, Laboratory of Cardiovascular Regenerative Medicine, Center for Molecular Medicine
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland.
Find out more about Dr. Boehm's lab at www.navbo.org/lab062014.
View all featured laboratories at www.navbo.org/membership/labs.
Decreased level of cord blood circulating endothelial colony-forming cells in preeclampsia
Hypertension
Preeclampsia is a pregnancy-related disorder associated with increased cardiovascular risk for the offspring. Endothelial colony-forming cells (ECFCs) are a subset of circulating endothelial progenitor cells that participate in the formation of vasculature during development. However, the effect of preeclampsia on fetal levels of ECFCs is largely unknown. In this study, the authors sought to determine whether cord blood ECFC abundance and function are altered in preeclampsia.
Renal blood flow and oxygenation drive nephron progenitor differentiation
American Journal of Physiology - Renal Physiology
During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. Here, the authors investigate the regulatory role of renal blood flow and oxygen concentration on nephron progenitor differentiation during ontogeny.
Novel expression of EGFL7 in placental trophoblast and endothelial cells and its implication in preeclampsia
Mechanisms of Development
The mammalian placenta is the site of nutrient and gas exchange between the mother and fetus, and is comprised of two principal cell types, trophoblasts and endothelial cells. Proper placental development requires invasion and differentiation of trophoblast cells, together with coordinated fetal vasculogenesis and maternal vascular remodeling.
Epidermal growth factor-like domain 7 is a marker of the endothelial lineage and active angiogenesis
Genesis
Epidermal growth factor-like domain 7 (Egfl7) expression in the developing embryo is largely restricted to sites of mesodermal progenitors of angioblasts/hemangioblasts and the vascular endothelium. The authors hypothesize that Egfl7 marks the endothelial lineage during embryonic development, and can be used to define the emergence of endothelial progenitor cells, as well as to visualize newly-forming vasculature in the embryo and during the processes of physiologic and pathologic angiogenesis in the adult.
Emerging topic: Flow-related epigenetic regulation of endothelial phenotype through DNA methylation
Vascular Pharmacology
Atherosclerosis is a multi-focal disease; it is associated with arterial curvatures, asymmetries and branches/bifurcations where non-uniform arterial geometry generates patterns of blood flow that are considerably more complex than elsewhere, and are collectively referred to as disturbed flow. Such regions are predisposed to atherosclerosis and are the sites of 'athero-susceptible' endothelial cells that express regionally different cell phenotypes than endothelium in nearby athero-protected locations.
Hemodynamic Disturbed Flow Induces Differential DNA Methylation of Endothelial Kruppel-Like Factor 4 (KLF4) Promoter In Vitro and In Vivo
Circulation Research
Hemodynamic disturbed flow is associated with susceptibility to atherosclerosis. Endothelial KLF4 is an important anti-inflammatory atheroprotective transcription factor that is suppressed in regions of disturbed flow.
Be sure to share your electronic publications with your NAVBO colleagues. Go to www.navbo.org/epubs to submit any recent publication.
|
NAVBO MEMBER PRESENTATIONS
|
Alberto Leguina-Ruzzi, Ph.D., Department of Hematology and Oncology, School of Medicine, Universidad Católica de Chile, will present “New Plasmatic Markers of Metabolic Syndrome in Young Adults: a possible diagnosis of an early endothelial dysfunction” in the Young Investigator's Symposium at the XVIII meeting of Clinical Chemistry taking place on August 6, 2014 at 8:30am in Salon Andes at the Crown Plaza Hotel in Santiago, Chile. Meeting web site: http://www.schqc.cl/congreso2014/
Dr. Sunder Sims-Lucas, Children's Hospital of Pittsburgh, will be giving a talk entitled "Kidney Derived Endothelial Progentiors Play a Critical Role During Development and Kidney Injury" at the Gordon Conference, Endothelial Cell Phenotypes in Health & Disease, taking place on July 5-6, 2014 at Melia Golf Vichy Catalan Business and Convention Center Girona, Spain
Share your upcoming presentations (regardless of the meeting) with fellow NAVBO members. We'll include the meeting name, session information and the title and time of your presentation. Email the information to bernadette@navbo.org or submit the info at www.navbo.org/MbrPresentations
Some reminders:
June 30 - Vote for the T-shirt design www.navbo.org/TshirtBallot
July 1 - Nominate a colleague for the 2015 Meritorious Awards - www.navbo.org/awards
August 1 - Abstract submission deadline for Vascular Biology www.navbo.org/vb2014/abstracts
August 15 - Early bird registration deadline for Vascular Biology www.navbo.org/RegisterVB2014
mTORC1 drives HIF-1α and VEGF-A signaling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
Nature
Recent clinical trials using rapalogues in tuberous sclerosis complex show regression in volume of typically vascularised tumours including angiomyolipomas and subependymal giant cell astrocytomas. By blocking mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signalling, rapalogue efficacy is likely to occur, in part, through suppression of hypoxia-inducible factors (HIFs) and vascular endothelial growth factors (VEGFs). We show that rapamycin reduces HIF-1α protein levels, and to a lesser extent VEGF-A levels, in renal cystadenoma cells in a Tsc2+/− mouse model.
Brain power: New insight into how the brain regulates its blood flow
Medical Xpress
In a new study published online in the Journal of the American Heart Association, researchers at Columbia Engineering report that they have identified a new component of the biological mechanism that controls blood flow in the brain. Led by Elizabeth M. C. Hillman, associate professor of biomedical engineering, the team has demonstrated, for the first time, that the vascular endothelium plays a critical role in the regulation of blood flow in response to stimulation in the living brain.
PAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin
Nature
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, researchers found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth.
Compound developed as cholesterol-fighting molecule can kill cancerous cells
News-Medical
Researchers at the University of Missouri have proven that a compound initially developed as a cholesterol-fighting molecule not only halts the progression of breast cancer, but also can kill the cancerous cells. "Cholesterol is a molecule found in all animal cells and serves as a structural component of cell membranes," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center at MU.
For a complete list of job postings, click here.
Have a job to post? Click here.
| Date |
Event |
More Information |
| June 30-July 2, 2014 |
ADMA 2014 |
Register |
| July 5-11, 2014 |
Gordon Research Conference and Seminar-- Endothelial Cell Phenotypes in Health & Disease |
Register |
| July 14-17, 2014 |
Vasculata 2014 |
Register
|
| September 7-11, 2014 |
11th International Symposium on Resistance Arteries (ISRA 2014) |
Register
|
| September 18-19, 2014 |
Small Blood Vessels: Big Health Problems? |
Register |
For more meetings of interest go to the NAVBO Calendar of Events.
If you already shop through Amazon, here's a new way for you to help NAVBO.
- Amazon will donate 0.5 percent of the price of your eligible AmazonSmile purchases to North American Vascular Biology Organization Inc whenever you shop on AmazonSmile.
- AmazonSmile is the same Amazon you know. Same products, same prices, same service.
- Support your charitable organization by starting your shopping at smile.amazon.com.
|
|
|
|
|
NAVBO NewsBEAT
Colby Horton, Vice President of Publishing, 469.420.2601
Download media kit
Jessica Taylor, Senior Medical Editor, 202.684.7169
Contribute news
Be sure to add us to your address book or safe sender list so our emails get to your inbox. Learn how.
Since 1994, the North American Vascular Biology Organization (NAVBO) has provided a forum for vascular biologists who are either in the traditional basic science disciplines (structural/molecular biology, cell biology, physiology) or studying the pathogenesis and treatment of human disease in disciplines such as medicine, pathology, surgery. NAVBO's membership is a mixture of scientists with different backgrounds and thus inherently different viewpoints on the same scientific problems. This makes for lively discussions and mutual education at our meetings and workshops. NAVBO provides the opportunity to communicate with a diverse cross-section of colleagues enhancing this discovery process, which will facilitate rapid translation into practical remedies.
This edition of the NAVBO NewsBEAT was sent to ##Email##. To unsubscribe, click here. Did someone forward this edition to you? Subscribe here — it's free!
|
|
Recent issues
June 5, 2014
May 22, 2014
May 8, 2014
April 10, 2014
|
|
|
|
|
|
|
