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Alec Clowes — Fondly Remembered
 If you knew Alec, there is no other way to remember him but fondly. He was truly a gentleman - a kind and generous man with a wonderful smile. That's how I'll remember him. Dr. Clowes was the eighth President of NAVBO and I enjoyed working with him very much. His involvement in NAVBO didn't stop there. Shortly before his death, Alec was honored by the Society of Vascular Surgery with their Lifetime Achievement Award; there is a write up in the Member News Section of our Summer Newsletter (on its way to you now via post). You can read that piece now at www.navbo.org/alec-clowes-remembered.
Quoting Dr. Stephen Schwartz: Alec was an exciting guy, full of ideas and able to get a lot done. He was a key collaborator in the work with Mike Reidy and myself on intimal hyperplasia. We quickly appointed Alec to Pathology as an Adjunct member of the faculty where he became a true paradigm for the role this Department can play in the interplay of basic science and clinical medicine. Dr. Klaus Ley remembers Dr. Clowes fondly: Alec was one of the editors of Hemostasis and Thrombosis: Basic Principles and Clinical Practice, the leading handbook in this area of medicine. Many years ago, he invited me to write the chapter on monocyte-endothelial-platelet interactions. I was quite junior and a little scared. Alec called me and was very kind and said he had confidence in my ability to write this, and this in turn gave me confidence. This book is now in its fifth edition. Alec's generosity, kindness and spirit will be missed. Dr. Richard Kenagy, stated "I do miss him, and I've nothing but admiration for the way he went about tying up loose ends and was able to stay at home with family to the end." Dr. Peter Libby provided this wonderful photo of Dr. Clowes from the 2004 IVBM in Toronto where NAVBO celebrated its first 10 years.
Our sincerest condolences to Alec's family, friends and colleagues. He will be sorely missed.
Bernadette Englert
VASCULATA 2015
August 3-6 in Charlottesville, VA.
Vasculata Web Casts are Available to Your Institution — You can still take advantage of this special introductory offer. A group at your institution can watch live streaming video from the University of Virginia and participate in Q&A sessions with the speakers. We are limiting the participation to 15 schools. The fee is only $1,000. For more information see www.navbo.org/events/vasculata2015/web-cast
VASCULAR BIOLOGY 2015
Join us October 18-22 in Hyannis, MA.
Go to www.navbo.org/vb2015 - Register online at www.navbo.org/RegisterVB2015
IVBM 2016
Be sure your calendar is marked for the 19th International Vascular Biology Meeting in Boston, Massachusetts from October 30-November 3, 2016. Bookmark www.ivbm2016.org for all of the meeting updates.
Congratulations to Tim Hla
Dr. Hla was presented with the Outstanding Achievement Award from the Eicosanoid Research Foundation and the International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases for his seminal work that led to the elucidation of the role of sphingosine-1-phosphate receptor and COX-2 in angiogenesis as well as their downstream signaling mechanisms. The conference was held in Budapest, Hungary from July 12-15. The award was presented to Dr. Hla at their Gala Dinner on July 14. Dr. Hla is a former President of NAVBO and co-organized the Biology of Signaling in the Cardiovascular System Workshop in 2009 and 2011. Congratulations Tim! A much deserved recognition!
Award Opportunities for Members
The Warren Alpert Foundation announces its call for nominations for the 2016 Warren Alpert Foundation Prize. The mission of the Warren Alpert Foundation Prize is to recognize and honor one or more scientists whose scientific achievements have led to the prevention, cure or treatment of human diseases or disorders, and/or whose research constitutes a seminal scientific finding that holds great promise of ultimately changing our understanding of or ability to treat disease. The unrestricted cash award accompanying the prize is U.S. $500,000, a citation and plaque. The recipient of the 2016 Warren Alpert Foundation Prize will participate in a special symposium in their honor at Harvard Medical School on October 6th, 2016. Nominations are accepted from academic institutions, centers of research, government, or other biomedical institutions from around the world. Self-nominations are not accepted. To nominate, please visit the Warren Alpert Foundation Prize nomination page at http://warrenalpert.org/nominations. The deadline for receipt of nominations is November 2nd, 2015.
Please welcome the following new members to NAVBO!
Joshua Drake, University of Virginia
Ana Estrada, University of Virginia
Michael Gutknecht, University of Virginia
Michael Harrison, Children's Hospital Los Angeles
Li-Hao Huang, Washington University School of Medicine
Madhara Kulkarni, LKC-Medcine
Victoria Osinski, University of Virginia
Nicolas Ricard, Yale Cardiovascular Research Ctr
Robert Rickel, University of Virginia
Claire Rosean, University of Virginia
Remember to send us your news. We love to brag about our members!
NAVBO Travel Award to GRC
The recipient of the NAVBO Travel Award to the 2015 Atherosclerosis GRC is Mark C. Blaser (third from the left). Mark is in the Institute of Biomaterials and Biomedical Engineering at the University of Toronto in the lab of Craig Simmons.
This is the first time NAVBO has presented a travel award to a Gordon Research Conference. NAVBO members who are chairing a vascular-related Gordon Research Conference should contact bernadette@navbo.org for details. Criteria for award applicants can be found at http://www.navbo.org/awards/trainees/GRCtravel.
 This month we are highlighting the lab of Dr. Jason Fish, Toronto General Research Institute, University Health Network and the University of Toronto, ON, Canada. Find out more about Dr. Fish's lab at www.navbo.org/lab072015.
View all featured laboratories at www.navbo.org/membership/labs
AIP1 expression in tumor niche suppresses tumor progression and metastasis
Cancer Research
Studies from tumor cells suggest that tumor suppressor AIP1 inhibits epithelial-mesenchymal transition (EMT). However, the role of AIP1 in the tumor microenvironment has not been examined. The authors show that a global or vascular endothelial cell (EC)-specific deletion of the AIP1 gene in mice augments tumor growth and metastasis in melanoma and breast cancer models
Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo
BMC Genomics
Atherosclerosis is a heterogeneously distributed disease of arteries in which the endothelium plays an important central role. Spatial transcriptome profiling of endothelium in pre-lesional arteries has demonstrated differential phenotypes primed for athero-susceptibility at hemodynamic sites associated with disturbed blood flow.
Mutations in Plasmalemma Vesicle Associated Protein (PLVAP) Result in Sieving Protein Losing Enteropathy Characterized by Hypoproteinemia, Hypoalbuminemia, and Hypertriglyceridemia
Cellular and Molecular Gastroenterology and Hepatology
Severe intestinal diseases observed in very young children are often the result of monogenic defects. The authors used whole-exome sequencing (WES) to examine genetics in a patient with a distinct severe form of protein-losing enteropathy (PLE) characterized by hypoproteinemia, hypoalbuminemia, and hypertriglyceridemia.
Differential Role of a NF-kappaB Transcriptional Response Element in Endothelial versus Intimal Cell VCAM-1 Expression
Circulation Research
Human and murine Vcam1 promoters contain 2 adjacent NF-?B-binding elements. Both are essential for cytokine-induced transcription of transiently transfected promoter-reporter constructs. However, the relevance of these insights to regulation of the endogenous Vcam1 gene and to pathophysiological processes in vivo remained unknown.
Inhibition of caspase-1 activation in endothelial cells improves angiogenesis
The Journal of Biological Chemistry
The buildup of fat in the blood makes a bad situation worse — it not only raises a person's risk for heart attack or stroke but also impairs the growth of new blood vessels. New work by researchers at Temple University School of Medicine shows that Caspase-1 plays a central role in blockade of vessel growth by hyperlipidemia and that inhibiting Caspase-1 activity could promote building new blood vessels and restoring blood supply to oxygen-starved tissues.
Molecular genetics of coronary artery disease
Journal of Human Genetics
Coronary artery disease (CAD) including myocardial infarction (MI) is a common disease and among the leading cause of death in the world. The onset of CAD depends on complex interactions of environmental and genetic factors. To clarify the genetic architecture of MI, investigators at the RIKEN Center for Integrative Medical Sciences in Japan conducted a genome-wide association study (GWAS) using nearly 100 000 gene-based single-nucleotide polymorphisms (SNPs) from a study initiated in 2000, and found Lymphotoxin-alpha (aka Tumor necrosis factor-beta) to be associated with the increased risk of MI in Japanese population.
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| Date |
Event |
More Information
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| Aug. 3-5, 2015 |
Vasculata 2015 at the University of Virginia |
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| Aug. 3-5, 2015 |
Global Summit on Stroke – Birmingham, UK |
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| Sept. 25-27, 2015 |
10th World Congress for Microcirculation - Kyoto, Japan |
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| Sept 29-30, 2015 |
Symposium on Cardiovascular Regenerative Medicine |
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| Sept. 29-30, 2015 |
The Third Circulation: Lymphatics at Regulators in Health and Disease |
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For more meetings of interest go to the NAVBO Calendar of Events.
For a complete list of job postings, click here.
Have a job to post? Click here.
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NAVBO NewsBEAT
Colby Horton, Vice President of Publishing, 469.420.2601
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Jessica Taylor, Senior Medical Editor, 202.684.7169
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Since 1994, the North American Vascular Biology Organization (NAVBO) has provided a forum for vascular biologists who are either in the traditional basic science disciplines (structural/molecular biology, cell biology, physiology) or studying the pathogenesis and treatment of human disease in disciplines such as medicine, pathology, surgery. NAVBO's membership is a mixture of scientists with different backgrounds and thus inherently different viewpoints on the same scientific problems. This makes for lively discussions and mutual education at our meetings and workshops. NAVBO provides the opportunity to communicate with a diverse cross-section of colleagues enhancing this discovery process, which will facilitate rapid translation into practical remedies.
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