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Extracellular adenosine has antiinflammatory effects and can prevent and treat osteoarthritis (OA) in animal models. Ticagrelor and clopidogrel are both used in patients with coronary artery disease, but only ticagrelor increases...

source: Arthritis & Rheumatology

Exercise programs rely on the overload principle, yet patients with knee osteoarthritis (OA) may not adequately progress exercises due to fear of exacerbating symptoms. In this study, researchers aimed to describe...

source: Osteoarthritis and Cartilage

Strengthening-based physical therapy (PT) is frequently recommended for persons with knee osteoarthritis (OA) and meniscal tear. On average, knee OA patients experience pain improvement while undergoing PT, but whether...

source: Osteoarthritis and Cartilage Open

The objective of this cross-sectional case-control study was to determine the prevalence and size of marginal and subarticular osteophytes in patients with osteoarthritis, and to compare these to that of a control group.

source: BMC Musculoskeletal Disorders

Researchers aimed to identify robustly differentially expressed long noncoding RNAs (lncRNAs) with osteoarthritis (OA) pathophysiology in cartilage and to explore potential target messenger...

source: Arthritis & Rheumatology

This study aimed to improve our understanding of the relationship between bone and cartilage by characterizing the morphological coupling between these mechanosensitive tissues exposed to the same mechanical environment within each knee....

source: Osteoarthritis and Cartilage Open

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